Marisa Aikins
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View article: Precision medicine-based platform to guide the treatment of EML4-ALK fusion lung cancers and other non-small cell lung cancers.
Precision medicine-based platform to guide the treatment of EML4-ALK fusion lung cancers and other non-small cell lung cancers. Open
146 Background: Lung cancer remains the number one cause of cancer-associated mortality worldwide, with a 10-year survival rate of only 5%. While most lung cancers are smoking related, 25% of non-small cell lung cancer (NSCLC) are diagnose…
View article: Supplementary Information from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas
Supplementary Information from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas Open
Supplementary Table 1 Supplementary Figures 1-4
View article: Data from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas
Data from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas Open
Purpose:Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide administration; however, they have been ineffective in providing significant increa…
View article: Data from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas
Data from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas Open
Purpose:Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide administration; however, they have been ineffective in providing significant increa…
View article: Supplementary Information from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas
Supplementary Information from Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas Open
Supplementary Table 1 Supplementary Figures 1-4
View article: Nanoparticle-based Immunotherapeutic Strategies to Target Acute Myeloid Leukemia and Cancer Stem Cells in Melanoma
Nanoparticle-based Immunotherapeutic Strategies to Target Acute Myeloid Leukemia and Cancer Stem Cells in Melanoma Open
Cancer is one of the most prevalent causes of death worldwide, but conventional treatments including surgical resection, chemotherapy, and radiation therapy have limited efficacy as evidenced by tumor recurrence and metastasis. Recent deve…
View article: Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies
Genetic Alterations in Gliomas Remodel the Tumor Immune Microenvironment and Impact Immune-Mediated Therapies Open
High grade gliomas are malignant brain tumors that arise in the central nervous system, in patients of all ages. Currently, the standard of care, entailing surgery and chemo radiation, exhibits a survival rate of 14-17 months. Thus, there …
View article: Engineered Nanoparticles for Cancer Vaccination and Immunotherapy
Engineered Nanoparticles for Cancer Vaccination and Immunotherapy Open
The immune system has evolved over time to protect the host from foreign microorganisms. Activation of the immune system is predicated on a distinction between self and nonself. Unfortunately, cancer is characterized by genetic alterations…
View article: Cancer Immunotherapy via Targeting Cancer Stem Cells Using Vaccine Nanodiscs
Cancer Immunotherapy via Targeting Cancer Stem Cells Using Vaccine Nanodiscs Open
Cancer stem cells (CSCs) proliferate extensively and drive tumor metastasis and recurrence. CSCs have been identified in over 20 cancer types to date, but it remains unknown how to target and eliminate CSCs in vivo. Aldehyde dehydrogenase …
View article: Efficient Lymph Node-Targeted Delivery of Personalized Cancer Vaccines with Reactive Oxygen Species-Inducing Reduced Graphene Oxide Nanosheets
Efficient Lymph Node-Targeted Delivery of Personalized Cancer Vaccines with Reactive Oxygen Species-Inducing Reduced Graphene Oxide Nanosheets Open
Therapeutic cancer vaccines require robust cellular immunity for the efficient killing of tumor cells, and recent advances in neoantigen discovery may provide safe and promising targets for cancer vaccines. However, elicitation of T cells …
View article: Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas
Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas Open
Purpose: Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide administration; however, they have been ineffective in providing significant incre…
View article: Vaccine Nanoparticles for Protection Against HIV Infection
Vaccine Nanoparticles for Protection Against HIV Infection Open
The development of a successful vaccine against HIV is a major global challenge. Antiretroviral therapy is the standard treatment against HIV-1 infection. However, only 46% of the eligible people received the therapy in 2015. Furthermore, …