Marisa W. Medina
YOU?
Author Swipe
View article: Development and Application of an Algorithm for Statin‐Induced Myopathy Based on Electronic Health Record‐Derived Structured Elements
Development and Application of an Algorithm for Statin‐Induced Myopathy Based on Electronic Health Record‐Derived Structured Elements Open
Purpose Considering the non‐specific nature of muscle symptoms, studies of statin‐induced myopathy (SIM) in electronic health records require accurate algorithms that can reliably identify true statin‐causing cases. Prior algorithms were c…
View article: <i>MIR192</i> Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion
<i>MIR192</i> Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion Open
Statins are a commonly prescribed cholesterol lowering drug class that can increase the risk of new-onset diabetes (NOD). To investigate the molecular mechanisms underlying this effect, we generated human induced pluripotent stem cells (iP…
View article: <i>SLCO1B1</i> Functional Variants, Bilirubin, Statin‐Induced Myotoxicity, and Recent Sub‐Saharan African Ancestry: A Precision Medicine Health Equity Study
<i>SLCO1B1</i> Functional Variants, Bilirubin, Statin‐Induced Myotoxicity, and Recent Sub‐Saharan African Ancestry: A Precision Medicine Health Equity Study Open
Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and…
View article: Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells
Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells Open
Background and Aims Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is reversible at early stages, making early identification of high-risk individuals clinically valuable. Previously, we demonstrated that patient-derived …
View article: Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function Open
Lipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and has been implicated in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Factors that augment l…
View article: X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction Open
Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired g…
View article: Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response Open
Background Statins lower circulating low-density lipoprotein cholesterol (LDLC) levels and reduce cardiovascular disease risk. Though highly efficacious in general, there is considerable inter-individual variation in statin efficacy that r…
View article: Development and application of an algorithm for statin-induced myopathy based on electronic health record-derived structured elements
Development and application of an algorithm for statin-induced myopathy based on electronic health record-derived structured elements Open
Objective Considering the non-specific nature of muscle symptoms, studies of statin-induced myopathy (SIM) in electronic health records require accurate algortihms that can reliably identify true statinrelated cases. However, prior algorit…
View article: X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction Open
Summary Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. We determined that f…
View article: Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease
Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease Open
Patient-derived induced pluripotent stem cells (iPSCs) have been transformational in biomedical research for their ability to differentiate into any cell type while retaining the genetic information of the donor individual, for example iPS…
View article: Effect of <i>SLCO1B1 T521C</i> on Statin‐Related Myotoxicity With Use of Lovastatin and Atorvastatin
Effect of <i>SLCO1B1 T521C</i> on Statin‐Related Myotoxicity With Use of Lovastatin and Atorvastatin Open
The association between the c.521T>C variant allele in SLCO1B1 (reference single nucleotide polymorphism (rs)4149056) and simvastatin‐induced myotoxicity was discovered over a decade ago; however, whether this relationship represents a cla…
View article: Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation
Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation Open
Background and Aims Induced pluripotent stem cells (iPSCs) provide an important tool for the generation of patient‐derived cells, including hepatocyte‐like cells, by developmental cues through an endoderm intermediate. However, most iPSC l…
View article: Identifying Genetic Modulators of Statin Response Using Subject-Derived Lymphoblastoid Cell Lines
Identifying Genetic Modulators of Statin Response Using Subject-Derived Lymphoblastoid Cell Lines Open
Although statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) have proven effective in reducing plasma low-density lipoprotein levels and risk of cardiovascular disease, their lipid lowering efficacy is highly variable among indiv…
View article: Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines
Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines Open
Association mapping with lymphoblastoid cell lines (LCLs) is a promising approach in pharmacogenomics research, and in the current study we utilize this model to perform association mapping for 29 chemotherapy drugs.
View article: A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines reveals a clinically relevant association with MGMT
A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines reveals a clinically relevant association with MGMT Open
Recently, lymphoblastoid cell lines (LCLs) have emerged as an innovative model system for mapping gene variants that predict dose response to chemotherapy drugs. In the current study, this strategy was expanded to the in vitro genome-wide …
View article: Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation
Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation Open
Induced pluripotent stem cells (iPSCs) provide an important tool for the generation patient-derived cells including hepatocyte-like cells via developmental cues through an endoderm intermediate. However, most iPSCs fail to differentiate in…
View article: Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation
Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation Open
Objective: TMEM55B (transmembrane protein 55B) is a phosphatidylinositol-(4,5)-bisphosphate (PI[4,5]P 2 ) phosphatase that regulates cellular cholesterol, modulates LDLR (low-density lipoprotein receptor) decay, and lysosome function. We t…
View article: The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change
The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change Open
In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response. A putative solution is to adj…
View article: Additional file 9 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 9 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 9: Table S9. Lead eQTL for average of endogenous and statin-treated LCL gene expression levels from meta-analysis with p<0.00001.
View article: Additional file 7 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 7 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 7: Table S7. Lead European ancestry eQTL for average of endogenous and statin-treated LCL gene expression levels.
View article: Additional file 6 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 6 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 6: Table S6. Lead statin-treated LCL eQTLs per gene from meta-analysis with p
View article: Additional file 4 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 4 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 4: Table S4. Lead statin-treated eQTLs per gene in LCLs from European ancestry subset.
View article: Additional file 5 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 5 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 5: Table S5. Lead statin-treated eQTLs per gene in LCLs from African American ancestry subset.
View article: Additional file 8 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 8 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 8: Table S8. Lead African American ancestry eQTL for average of endogenous and statin-treated LCL gene expression levels.
View article: Additional file 1 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 1 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 1: Table S1. Lead endogenous eQTLs per gene in LCLs from European ancestry subset.