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View article: In Vivo Characterization of ONL1204, a Small Peptide Inhibitor of the Fas Receptor, as a Potential Neuroprotective Therapy for Geographic Atrophy and Dry Age-Related Macular Degeneration
In Vivo Characterization of ONL1204, a Small Peptide Inhibitor of the Fas Receptor, as a Potential Neuroprotective Therapy for Geographic Atrophy and Dry Age-Related Macular Degeneration Open
Background: Age-related macular degeneration (AMD) is a major cause of irreversible vision loss in the developed world, and the approved products for geographic atrophy (GA), a late-stage form of dry AMD, have shown limited efficacy and re…
View article: Cigarette smoke and biological age induce degenerative heterogeneity in retinal pigment epithelium
Cigarette smoke and biological age induce degenerative heterogeneity in retinal pigment epithelium Open
Environmental exposure such as cigarette smoke induces epigenetic changes that can induce degenerative heterogeneity and accelerate aging. In early age-related macular degeneration (AMD), the leading worldwide cause of blindness among the …
View article: Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain
Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain Open
Maternal smoking during pregnancy (MSDP) is associated with significant cognitive and behavioral effects on offspring. While neurodevelopmental outcomes have been studied for prenatal exposure to nicotine, the main psychoactive component o…
View article: Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity Open
Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathog…
View article: Cell Death in AMD: The Rationale for Targeting Fas
Cell Death in AMD: The Rationale for Targeting Fas Open
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world. While great advances have been made in the treatment of the neovascular (“wet”) form of the disease, there is still a significant n…
View article: Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity Open
Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathog…
View article: Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity Open
Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathog…
View article: Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction
Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction Open
The nuclear factor‐erythroid 2‐related factor‐2 (Nrf2), a major antioxidant transcription factor, is decreased in several age‐related diseases including age‐related macular degeneration (AMD), the most common cause of blindness among the e…
View article: A widespread decrease of chromatin accessibility in age-related macular degeneration
A widespread decrease of chromatin accessibility in age-related macular degeneration Open
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. The extent to which epigenetic changes regulate AMD progression is unclear. Here we globally profiled chromatin accessibility in the retina and retinal …
View article: Oxidative Stress Induces an Interactive Decline in <i>Wnt</i> and <i>Nrf2</i> Signaling in Degenerating Retinal Pigment Epithelium
Oxidative Stress Induces an Interactive Decline in <i>Wnt</i> and <i>Nrf2</i> Signaling in Degenerating Retinal Pigment Epithelium Open
Our data offer new insights into how combined modern oxidative stresses of cigarette smoking and HFD contribute to GA through an interactive decline in Wnt and Nrf2 signaling. Antioxid. Redox Signal. 29, 389-407.