Marissa K. Caldow
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View article: The effect of enteral glycine on plasma glycine and muscle structure, size, and function in the critically ill: A randomized controlled trial
The effect of enteral glycine on plasma glycine and muscle structure, size, and function in the critically ill: A randomized controlled trial Open
This trial was prospectively registered with the Australian and New Zealand Clinical Trials Registry (www.anzctr.org.au) ANZCTR ACTRN12618000409279.
View article: Evaluating skeletal muscle wasting and weakness in models of critical illness
Evaluating skeletal muscle wasting and weakness in models of critical illness Open
Skeletal muscle wasting and weakness are common complications associated with admission to the intensive care unit (ICU), with the loss of muscle mass and function increasing mortality and contributing to physical impairments post-discharg…
View article: Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation
Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation Open
The neuronal progenitor NG108-15 neuroblastoma x glioma cell line proliferates indefinitely in vitro and is capable of directed differentiation into cholinergic neurons. The cell line is a robust model for investigating neuronal differenti…
View article: Plasma beta‐hydroxy‐beta‐methylbutyrate availability after enteral administration during critical illness after trauma: An exploratory study
Plasma beta‐hydroxy‐beta‐methylbutyrate availability after enteral administration during critical illness after trauma: An exploratory study Open
Background During critical illness skeletal muscle wasting occurs rapidly. Although beta‐hydroxy‐beta‐methylbutyrate (HMB) is a potential treatment to attenuate this process, the plasma appearance and muscle concentration is uncertain. Met…
View article: Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients
Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients Open
Background Critically ill patients suffer from acute muscle wasting, which is associated with significant physical functional impairment. We describe data from nested muscle biopsy studies from two trials of functional electrical stimulati…
View article: Time-resolved phosphoproteome and proteome analysis reveals kinase signaling on master transcription factors during myogenesis
Time-resolved phosphoproteome and proteome analysis reveals kinase signaling on master transcription factors during myogenesis Open
View article: Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy
Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy Open
Background Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the dystrophin gene), which is the most common and severe of the muscular dystrophies. To our knowledge, the distr…
View article: Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia–reperfusion damage
Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia–reperfusion damage Open
Background Oxidative stress is implicated in the insidious loss of muscle mass and strength that occurs with age. However, few studies have investigated the role of iron, which is elevated during ageing, in age‐related muscle wasting and b…
View article: Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling
Glycine Protects Muscle Cells From Wasting in vitro via mTORC1 Signaling Open
Glycine supplementation can protect skeletal muscles of mice from cancer-induced wasting, but the mechanisms underlying this protection are not well-understood. The aim of this study was to determine whether exogenous glycine directly prot…
View article: Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice
Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice Open
View article: Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury
Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury Open
Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a persistent inflammatory response. The janus kinase (Jak)/signal transducer and activator of transcription (Stat) pathway mediates inflammatory …
View article: Choline administration attenuates aspects of the dystrophic pathology in mdx mice
Choline administration attenuates aspects of the dystrophic pathology in mdx mice Open
View article: No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men.
No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men. Open
Growth factors can be isolated from bovine milk to form a whey growth factor extract (WGFE). This study examined whether WGFE promoted activation of the AKT/mTOR pathway enabling increased lean tissue mass and strength in resistance traine…
View article: Muscle-specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation
Muscle-specific deletion of SOCS3 does not reduce the anabolic response to leucine in a mouse model of acute inflammation Open
View article: Glycine metabolism in skeletal muscle
Glycine metabolism in skeletal muscle Open
Recent studies demonstrate that supplemental glycine effectively protects muscles in a variety of wasting models, including cancer cachexia, sepsis, and reduced caloric intake. The underlying mechanisms responsible for the effects of glyci…
View article: The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study
The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study Open
View article: The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study
The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study Open
Skeletal muscle, particularly the quadriceps, is affected in people with knee OA where elevated FoxO1 protein expression was associated with reduced muscle strength. While IL-15 protein expression in the muscle was lower in the knee OA gro…
View article: L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism
L-Citrulline Protects Skeletal Muscle Cells from Cachectic Stimuli through an iNOS-Dependent Mechanism Open
Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availability. To date, the direct effects of increased L-citrulline concentrations in muscle have been completely neglected. Therefore, we determi…
View article: Early myogenic responses to acute exercise before and after resistance training in young men
Early myogenic responses to acute exercise before and after resistance training in young men Open
To enable dynamic regulation of muscle mass and myofiber repair following injury, a satellite cell precursor population exists to supply additional nuclei. Activated satellite cells express many genes and associated proteins necessary for …
View article: Postprandial Responses to Lipid and Carbohydrate Ingestion in Repeated Subcutaneous Adipose Tissue Biopsies in Healthy Adults
Postprandial Responses to Lipid and Carbohydrate Ingestion in Repeated Subcutaneous Adipose Tissue Biopsies in Healthy Adults Open
Adipose tissue is a primary site of meta-inflammation. Diet composition influences adipose tissue metabolism and a single meal can drive an inflammatory response in postprandial period. This study aimed to examine the effect lipid and carb…
View article: Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy
Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy Open
Resistance training (RT) has the capacity to increase skeletal muscle mass, which is due in part to transient increases in the rate of muscle protein synthesis during postexercise recovery. The role of ribosome biogenesis in supporting the…
View article: Citrulline Does Not Prevent Skeletal Muscle Wasting or Weakness in Limb-Casted Mice
Citrulline Does Not Prevent Skeletal Muscle Wasting or Weakness in Limb-Casted Mice Open
View article: Short communication: Bovine-derived proteins activate STAT3 in human skeletal muscle in vitro
Short communication: Bovine-derived proteins activate STAT3 in human skeletal muscle in vitro Open
Bovine milk contains biologically active peptides that may modulate growth and development within humans. In this study, targeted bovine-derived proteins were evaluated for their effects on signal transducer and activator of transcription-…