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View article: ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice Open
Nanosized zinc oxide (nZnO) metal particles are used in skin creams and sunscreens to enhance their texture and optical properties as UV filters. Despite their common use, little is known about the molecular mechanisms of nZnO exposure on …
View article: Effects of Superficial Scratching and Engineered Nanomaterials on Skin Gene Profiles and Microbiota in SKH-1 Mice
Effects of Superficial Scratching and Engineered Nanomaterials on Skin Gene Profiles and Microbiota in SKH-1 Mice Open
Scratching damages upper layers of the skin, breaks this first line of immune defence, and leads to inflammation response, which often also modifies the microbiota of the skin. Although the healing of incision wounds is well-described, the…
View article: Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs
Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs Open
Consumers and manufacturers are exposed to nanosized zinc oxide (nZnO) and silver particles (nAg) via airways, but their biological effects are still not fully elucidated. To understand the immune effects, we exposed mice to 2, 10, or 50 μ…
View article: Microbiome induced complement synthesized in the gut protects against enteric infections
Microbiome induced complement synthesized in the gut protects against enteric infections Open
Canonically, complement is a serum-based host defense system that protects against systemic microbial invasion. Little is known about the production and function of complement components on mucosal surfaces. Here we show gut complement com…
View article: Skin microbiota of oxazolone-induced contact hypersensitivity mouse model
Skin microbiota of oxazolone-induced contact hypersensitivity mouse model Open
Contact allergy is a common skin allergy, which can be studied utilising contact hypersensitivity (CHS) animal model. However, it is not clear, whether CHS is a suitable model to investigate skin microbiota interactions. We characterised t…
View article: Profiling Non-Coding RNA Changes Associated with 16 Different Engineered Nanomaterials in a Mouse Airway Exposure Model
Profiling Non-Coding RNA Changes Associated with 16 Different Engineered Nanomaterials in a Mouse Airway Exposure Model Open
Perturbations in cellular molecular events and their associated biological processes provide opportunities for hazard assessment based on toxicogenomic profiling. Long non-coding RNAs (lncRNAs) are transcribed from DNA but are typically no…
View article: Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways
Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways Open
Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational methods to map molecular events and biological processes. In this study, the transcriptomic and immunopathological changes associated with airway exp…
View article: Pulmonary toxicity of synthetic amorphous silica – effects of porosity and copper oxide doping
Pulmonary toxicity of synthetic amorphous silica – effects of porosity and copper oxide doping Open
Materials can be modified for improved functionality. Our aim was to test whether pulmonary toxicity of silica nanomaterials is increased by the introduction of: a) porosity; and b) surface doping with CuO; and whether c) these modificatio…
View article: Mechanistic Similarities between 3D Human Bronchial Epithelium and Mice Lung, Exposed to Copper Oxide Nanoparticles, Support Non‐Animal Methods for Hazard Assessment
Mechanistic Similarities between 3D Human Bronchial Epithelium and Mice Lung, Exposed to Copper Oxide Nanoparticles, Support Non‐Animal Methods for Hazard Assessment Open
The diversity and increasing prevalence of products derived from engineered nanomaterials (ENM), warrants implementation of non‐animal approaches to health hazard assessment for ethical and practical reasons. Although non‐animal approaches…
View article: Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation
Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation Open
CuO as well as its functionalized forms worsen allergic airway inflammation by causing neutrophilia in the lungs, however, our results also show that surface PEGylation can be a promising approach for inhibiting the effects of pristine CuO…
View article: Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model
Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model Open
More than 5% of any population suffers from asthma, and there are indications that these individuals are more sensitive to nanoparticle aerosols than the healthy population. We used an air-liquid interface model of inhalation exposure to i…
View article: Additional file 3: of Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation
Additional file 3: of Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation Open
Table S3 Lists of the differentially expressed genes from the microarray experiment. Experimental groups of PBS-challenged or OVA-challenged mice that were treated with the same CuO material were combined and compared against their corresp…
View article: Additional file 2: of Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation
Additional file 2: of Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation Open
Table S2. Lists of the differentially expressed genes from the microarray experiment. The tables with the differentially expressed genes in each of the relevant pairwise comparisons (each experimental group compared against corresponding P…
View article: Additional file 4: of Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation
Additional file 4: of Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation Open
Table S4. Lists of the differentially expressed genes from the microarray experiment. Experimental groups treated with modified CuO materials were compared against the groups treated with the corresponding dose of core CuO in PBS-challenge…
View article: Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month
Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month Open
Nanofibrillated cellulose (NFC) is a renewable nanomaterial that has beneficial uses in various applications such as packaging materials and paper. Like carbon nanotubes (CNT), NFCs have high aspect ratio and favorable mechanical propertie…