Marius Distler
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View article: Supplementary Table S5 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Table S5 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Proportion of PD-1+ or TIGIT+ cells of CD8+ T cells, Tconv or Treg ± standard deviation in PDAC according to clinicopathological parameters. Statistics (Stat.) with unpaired two-sided t-test or one-way ANOVA, respectively. *, P < 0.05; **,…
View article: Supplementary Figure S10 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S10 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Kaplan-Meier analyses for PD-1 and TIGIT co-expression in blood.
View article: Supplementary Figure S12 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S12 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Survival analyses for PD-1 and TIGIT co-expression in PDAC.
View article: Supplementary Figure S11 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S11 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Survival analyses for PD-1 and TIGIT co-expression in blood.
View article: Supplementary Table S2 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Table S2 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Antibodies used for flow cytometry.
View article: Supplementary Figure S7 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S7 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Cytokine expression as a function of PD-1 and TIGIT expression in blood.
View article: Supplementary Figure S2 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S2 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Survival analyses for clinicopathological parameters and for TIGIT and PD-1 expression in blood.
View article: Supplementary Table S1 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Table S1 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Clinicopathological characteristics of patients in blood and PDAC cohort.
View article: Supplementary Table S3 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Table S3 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Frequencies of CD8+ T cells, Tconv and Treg among all CD3+ T cells ± standard deviation according to clinicopathological parameters. Statistics (Stat.) with unpaired two-sided t-test or one-way ANOVA, respectively. *, P < 0.05
View article: Supplementary Figure S9 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S9 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
General EOMES expression and expression as a function of PD-1 and TIGIT in blood.
View article: Supplementary Figure S3 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S3 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Survival analyses for PD-1 and TIGIT expression in PDAC.
View article: Supplementary Table S4 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Table S4 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Proportion of PD-1+ or TIGIT+ cells of CD8+ T cells, Tconv or Treg ± standard deviation in patient blood according to clinicopathological parameters with standard deviation. Statistics (Stat.) with unpaired two-sided t-test or one-way ANOV…
View article: Supplementary Figure S13 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S13 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
. Illustration depicting T cell subsets that enable dichotomization of PDAC patients with significantly different survival functions.
View article: Supplementary Figure S1 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Supplementary Figure S1 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer Open
Gating strategy and correlation of PD-1 and TIGIT expression.
View article: Surgical workflow analysis for Surgomics and context-aware assistance in robot-assisted minimally invasive esophagectomy (RAMIE): a retrospective, single-arm, multicenter annotation and machine learning study
Surgical workflow analysis for Surgomics and context-aware assistance in robot-assisted minimally invasive esophagectomy (RAMIE): a retrospective, single-arm, multicenter annotation and machine learning study Open
The RAMIE workflow was successfully modeled and validated in a retrospective multicenter setting. Despite high variability in phase duration between surgical centers, ML-based phase recognition achieved highly promising results.
View article: Indirect calorimetry identifies hypermetabolism associated with muscle wasting and increased risk of energy deficit in ICU patients
Indirect calorimetry identifies hypermetabolism associated with muscle wasting and increased risk of energy deficit in ICU patients Open
View article: Decentralized, privacy-preserving surgical video analysis with Swarm Learning
Decentralized, privacy-preserving surgical video analysis with Swarm Learning Open
Background Progress in artificial intelligence-based analysis of surgical videos has been constrained by reliance on manual frame-level annotations rather than patient-level outcomes. In addition, concerns about data privacy restrict the e…
View article: Predicting resectability after neoadjuvant chemotherapy for patients with borderline resectable pancreatic cancer: a single center, retrospective trial
Predicting resectability after neoadjuvant chemotherapy for patients with borderline resectable pancreatic cancer: a single center, retrospective trial Open
Background/Objectives Pancreatic ductal adeno carcinoma (PDAC) in its borderline resectable (BR) stage often limits the possibility of complete resection, currently the only potential path to a cure. Neoadjuvant chemotherapy seeks to downs…
View article: Sarcopenia in Colorectal Cancer Surgery—Minimally Invasive vs. Open
Sarcopenia in Colorectal Cancer Surgery—Minimally Invasive vs. Open Open
Background Sarcopenia, characterized by loss of skeletal muscle mass and strength, is prevalent in patients undergoing treatment for colorectal cancer. Sarcopenia's prevalence in patients with cancer can reach up to 50% and is known to exa…
View article: Impact of laparoscopic training, haptic feedback and visual haptic latency on virtual fine motor performance
Impact of laparoscopic training, haptic feedback and visual haptic latency on virtual fine motor performance Open
Advancements in minimally invasive surgery, including haptic feedback and telesurgery systems, offer potential benefits for surgical education and patient outcomes. However, the impact of general visuomotor skills (GVS), laparoscopic exper…
View article: Appendix300: A multi-institutional laparoscopic appendectomy video dataset for computational modeling tasks
Appendix300: A multi-institutional laparoscopic appendectomy video dataset for computational modeling tasks Open
Structured Abstract Background The limited availability of diverse and representative training data poses a critical barrier to the development of clinically relevant computational tools for intraoperative surgical decision support. Surgic…
View article: Translationale Herausforderungen und klinisches Potenzial von künstlicher Intelligenz in der minimal-invasiven Chirurgie
Translationale Herausforderungen und klinisches Potenzial von künstlicher Intelligenz in der minimal-invasiven Chirurgie Open
Zusammenfassung Künstliche Intelligenz (KI) bietet enormes Potenzial für die Chirurgie. Anwendungsfelder reichen von interdisziplinärer Therapiestratifizierung über die Unterstützung der Operationsplanung bis zur Entscheidungsunterstützung…
View article: 17.6% of patients in a German cohort with exocrine pancreatic cancer were diagnosed with a genetic tumor syndrome—a case for universal genetic testing?
17.6% of patients in a German cohort with exocrine pancreatic cancer were diagnosed with a genetic tumor syndrome—a case for universal genetic testing? Open
View article: Postoperative complication management: How do large language models measure up to human expertise?
Postoperative complication management: How do large language models measure up to human expertise? Open
Managing postoperative complications is an essential part of surgical care and largely depends on the medical team’s experience. Large Language Models (LLMs) have demonstrated immense potential in supporting medical professionals. To evalu…
View article: Pancreatoduodenectomy versus total pancreatectomy and simultaneous intraportal islet autotransplantation for periampullary cancer at high-risk of postoperative pancreatic fistula (XANDTX-trial): Protocol of a randomized controlled pilot trial
Pancreatoduodenectomy versus total pancreatectomy and simultaneous intraportal islet autotransplantation for periampullary cancer at high-risk of postoperative pancreatic fistula (XANDTX-trial): Protocol of a randomized controlled pilot trial Open
Introduction Pancreatic surgery remains associated with significant morbidity. Pancreatoduodenectomy (PD) with high-risk stigmata for postoperative pancreatic fistula (POPF) may delay or hinder administration of adjuvant therapy. Total pan…
View article: Does perioperative hydrocortisone reduce morbidity after pancreatoduodenectomy? A propensity score matched analysis
Does perioperative hydrocortisone reduce morbidity after pancreatoduodenectomy? A propensity score matched analysis Open
The use of steroids in pancreatic surgery may reduce complications through the anti-inflammatory potential. We aimed to evaluate the impact of hydrocortisone (HC) on postoperative morbidity after pancreatoduodenectomy (PD). The data were r…
View article: Vision-language models for automated video analysis and documentation in laparoscopic surgery: a proof-of-concept study
Vision-language models for automated video analysis and documentation in laparoscopic surgery: a proof-of-concept study Open
Background: The ongoing shortage of medical personnel highlights the urgent need to automate clinical documentation and reduce administrative burden. Large vision-language models (VLMs) offer promising potential for supporting surgical doc…
View article: Algorithm-based intraoperative diagnosis of liver tumors using infrared spectroscopy
Algorithm-based intraoperative diagnosis of liver tumors using infrared spectroscopy Open
Liver cancer, including hepatocellular carcinoma (HCC), cholangiocellular carcinoma (CCC), and metastases, presents diagnostic challenges during surgery due to its infiltrative nature. Accurate intraoperative classification and margin asse…
View article: Mission Balance: Generating Under-represented Class Samples using Video Diffusion Models
Mission Balance: Generating Under-represented Class Samples using Video Diffusion Models Open
Computer-assisted interventions can improve intra-operative guidance, particularly through deep learning methods that harness the spatiotemporal information in surgical videos. However, the severe data imbalance often found in surgical vid…
View article: Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells
Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells Open