Marius Kröger
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View article: Redefine photoprotection: Sun protection beyond sunburn
Redefine photoprotection: Sun protection beyond sunburn Open
Excessive exposure to ultraviolet (UV) light leads to acute and chronic UV damage and is the main risk factor for the development of skin cancer. In most countries with western lifestyle, the topical application of sunscreens on UV‐exposed…
View article: <scp>Far‐UVC</scp>‐ and <scp>UVB</scp>‐induced <scp>DNA</scp> damage depending on skin type
<span>Far‐UVC</span>‐ and <span>UVB</span>‐induced <span>DNA</span> damage depending on skin type Open
Far‐UVC radiation sources of wavelengths 222 nm and 233 nm represent an interesting potential alternative for the antiseptic treatment of the skin due to their high skin compatibility. Nevertheless, no studies on far‐UVC‐induced DNA damage…
View article: Human glabrous skin contains crystallized urea dendriform structures in the <i>stratum corneum</i> which affect the hydration levels
Human glabrous skin contains crystallized urea dendriform structures in the <i>stratum corneum</i> which affect the hydration levels Open
Glabrous skin is hair‐free skin with a high density of sweat glands, which is found on the palms, and soles of mammalians, covered with a thick stratum corneum . Dry hands are often an occupational problem which deserves attention from der…
View article: Tattoo Pigments Are Localized Intracellularly in the Epidermis and Dermis of Fresh and Old Tattoos: In vivo Study Using Two-Photon Excited Fluorescence Lifetime Imaging
Tattoo Pigments Are Localized Intracellularly in the Epidermis and Dermis of Fresh and Old Tattoos: In vivo Study Using Two-Photon Excited Fluorescence Lifetime Imaging Open
Background: The knowledge about the location and kinetics of tattoo pigments in human skin after application and during the recovery is restricted due to the limitation of in vivo methods for visualizing pigments. Here, the localization an…
View article: Segmentations of carcinogenic DNA damages in WSI
Segmentations of carcinogenic DNA damages in WSI Open
The dataset includes patches from WSI images of the carcinogenic DNA damages caused by ultraviolet (UV) radiation on excised abdominal human skin, excised porcine skin and in vitro skin models with different melanin indices. Two predominan…
View article: Segmentations of carcinogenic DNA damages in WSI
Segmentations of carcinogenic DNA damages in WSI Open
The dataset includes patches from WSI images of the carcinogenic DNA damages caused by ultraviolet (UV) radiation on excised abdominal human skin, excised porcine skin and in vitro skin models with different melanin indices. Two predominan…
View article: Segmentations of carcinogenic DNA damages in WSI
Segmentations of carcinogenic DNA damages in WSI Open
The dataset includes patches from WSI images of the carcinogenic DNA damages caused by ultraviolet (UV) radiation on excised abdominal human skin, excised porcine skin and in vitro skin models with different melanin indices. Two predominan…
View article: Label-free imaging of M1 and M2 macrophage phenotypes in the human dermis in vivo using two-photon excited FLIM
Label-free imaging of M1 and M2 macrophage phenotypes in the human dermis in vivo using two-photon excited FLIM Open
Macrophages (ΜΦs) are important immune effector cells that promote (M1 ΜΦs) or inhibit (M2 ΜΦs) inflammation and are involved in numerous physiological and pathogenic immune responses. Their precise role and relevance, however, are not ful…
View article: Penetration Depth of Propylene Glycol, Sodium Fluorescein and Nile Red into the Skin Using Non-Invasive Two-Photon Excited FLIM
Penetration Depth of Propylene Glycol, Sodium Fluorescein and Nile Red into the Skin Using Non-Invasive Two-Photon Excited FLIM Open
The stratum corneum (SC) forms a strong barrier against topical drug delivery. Therefore, understanding the penetration depth and pathways into the SC is important for the efficiency of drug delivery and cosmetic safety. In this study, TPT…
View article: Label-free imaging of macrophage phenotypes and phagocytic activity in the human dermis <i>in vivo</i> using two-photon excited FLIM
Label-free imaging of macrophage phenotypes and phagocytic activity in the human dermis <i>in vivo</i> using two-photon excited FLIM Open
Macrophages (MΦs) are important immune effector cells that promote (M1 MΦs) or inhibit (M2 MΦs) inflammation and are involved in numerous physiological and pathogenic immune responses. Their precise role and relevance, however, is not full…
View article: Characterization of Collagen I Fiber Thickness, Density, and Orientation in the Human Skin In Vivo Using Second-Harmonic Generation Imaging
Characterization of Collagen I Fiber Thickness, Density, and Orientation in the Human Skin In Vivo Using Second-Harmonic Generation Imaging Open
The assessment of dermal alterations is necessary to monitor skin aging, cancer, and other skin diseases and alterations. The gold standard of morphologic diagnostics is still histopathology. Here, we proposed parameters to distinguish mor…
View article: Microneedle-Facilitated Intradermal Proretinal Nanoparticle Delivery
Microneedle-Facilitated Intradermal Proretinal Nanoparticle Delivery Open
Topical retinoid treatments stimulate biological activities in the skin. The main physical barrier, which limits the efficacy of transdermal drug delivery, is the stratum corneum. Proretinal nanoparticles (PRN) have already been proven to …