Marjia Afrin
YOU?
Author Swipe
View article: <i>Spatial Characterization of Molecular Pathways Suggests the Dysregulation of LGR5 Expressing Fibroblasts in Patients with sclerodermatous Chronic Graft-Vs-Host Disease</i>
<i>Spatial Characterization of Molecular Pathways Suggests the Dysregulation of LGR5 Expressing Fibroblasts in Patients with sclerodermatous Chronic Graft-Vs-Host Disease</i> Open
Chronic graft-vs-host disease (cGVHD) is a common and often morbid immune related complication of allogeneic hematopoietic cell transplantation (HCT), and a major obstacle to the success of this cellular therapy. Its presentation is hetero…
View article: POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes
POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes Open
Trypanosoma brucei causes human African trypanosomiasis and sequentially expresses distinct VSGs, its major surface antigen, to achieve host immune evasion. VSGs are monoallelically expressed from subtelomeric loci, and telomere proteins r…
View article: <i>Trypanosoma brucei</i>PolIE suppresses telomere recombination
<i>Trypanosoma brucei</i>PolIE suppresses telomere recombination Open
Telomeres are essential for genome integrity and stability. In T. brucei that causes human African trypanosomiasis, the telomere structure and telomere proteins also influence the virulence of the parasite, as its major surface antigen inv…
View article: <i>Tb</i>TRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain
<i>Tb</i>TRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain Open
Telomere repeat-containing RNA (TERRA) has been identified in multiple organisms including Trypanosoma brucei, a protozoan parasite that causes human African trypanosomiasis. T. brucei regularly switches its major surface antigen, VSG, to …
View article: <i>Tb</i> RAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing
<i>Tb</i> RAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing Open
The electrostatics-based dsDNA binding activity in Tb RAP1 NLS can be diminished by phosphorylation of NLS-adjacent S residues.
View article: Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions
Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions Open
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, to evade the host immune response. VSGs are expressed from subtelomeres in a monoallelic fashion. Tb RAP1, a telomere protein, i…