Mark A. Benhaim
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View article: Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice
Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice Open
HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here, we used cryo-electron tomog…
View article: Cryo-ET of HIV reveals Env positioning on Gag lattice and structural variation among Env trimers
Cryo-ET of HIV reveals Env positioning on Gag lattice and structural variation among Env trimers Open
Summary HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion context has eluded detailed characterization. Here we used cryo-electro…
View article: Structural monitoring of a transient intermediate in the hemagglutinin fusion machinery on influenza virions
Structural monitoring of a transient intermediate in the hemagglutinin fusion machinery on influenza virions Open
Structural mass spectrometry enables dissection of a transient activated ensemble in influenza hemagglutinin fusion machinery.
View article: New Biophysical Approaches Reveal the Dynamics and Mechanics of Type I Viral Fusion Machinery and Their Interplay with Membranes
New Biophysical Approaches Reveal the Dynamics and Mechanics of Type I Viral Fusion Machinery and Their Interplay with Membranes Open
Protein-mediated membrane fusion is a highly regulated biological process essential for cellular and organismal functions and infection by enveloped viruses. During viral entry the membrane fusion reaction is catalyzed by specialized prote…
View article: Bridging protein structure, dynamics, and function using hydrogen/deuterium‐exchange mass spectrometry
Bridging protein structure, dynamics, and function using hydrogen/deuterium‐exchange mass spectrometry Open
Much of our understanding of protein structure and mechanistic function has been derived from static high‐resolution structures. As structural biology has continued to evolve it has become clear that high‐resolution structures alone are un…
View article: De novo design of tunable, pH-driven conformational changes
De novo design of tunable, pH-driven conformational changes Open
Designed to respond Protein design has achieved success in finding sequences that fold to very stable target structures. Protein function, however, often requires conformational dynamics. Boyken et al. describe designed proteins that under…