Mark A. Hoffman
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View article: Updating the Epidemiology of Blastomycosis and Histoplasmosis in the United States, Using National Electronic Health Record Data, 2013–2023
Updating the Epidemiology of Blastomycosis and Histoplasmosis in the United States, Using National Electronic Health Record Data, 2013–2023 Open
Background Where surveillance data are limited, nationally representative electronic health records allow for geographic, temporal, and demographic characterization of the fungal diseases blastomycosis and histoplasmosis. Methods We identi…
View article: Epidemiology of Aspergillosis Diagnoses in the U.S. using a National EHR Database, 2013-2023
Epidemiology of Aspergillosis Diagnoses in the U.S. using a National EHR Database, 2013-2023 Open
Importance Aspergillosis is an under-recognized fungal infection associated with rising hospitalizations, concerns about antifungal resistance, and substantial morbidity and mortality in the U.S. Yet, national data on aspergillosis remain …
View article: Updating the epidemiology of blastomycosis and histoplasmosis in the United States, using national electronic health record data, 2013 - 2023
Updating the epidemiology of blastomycosis and histoplasmosis in the United States, using national electronic health record data, 2013 - 2023 Open
Introduction Where surveillance data are limited, nationally-representative electronic health records allow for geographic, temporal, and demographic characterization of the fungal diseases blastomycosis and histoplasmosis. Methods We iden…
View article: YouTube User Traffic to Paired Epilepsy Education Videos in English and Spanish: Comparative Study
YouTube User Traffic to Paired Epilepsy Education Videos in English and Spanish: Comparative Study Open
Background Effectively managing epilepsy in children necessitates the active engagement of parents, a factor that is reliant on their understanding of this neurological disorder. Widely available, high-quality, patient-focused, bilingual v…
View article: Utilization of geospatial distribution in the measurement of study cohort representativeness
Utilization of geospatial distribution in the measurement of study cohort representativeness Open
Together, these metrics provide a comprehensive spatial assessment of a study cohort with respect to a broader target population. Such an approach offers researchers a toolset by which to target expected generalization of results derived f…
View article: Enhancing Accessibility and Engagement: A Comparative Analysis of User Traffic to Paired Clinical Videos in English and Spanish (Preprint)
Enhancing Accessibility and Engagement: A Comparative Analysis of User Traffic to Paired Clinical Videos in English and Spanish (Preprint) Open
BACKGROUND Effectively managing epilepsy in children necessitates the active engagement of parents, a factor that is reliant on their understanding of this neurological disorder. OBJECTIVE This study analyzes traffic to paired education…
View article: Committing to genomic answers for all kids: Evaluating inequity in genomic research enrollment
Committing to genomic answers for all kids: Evaluating inequity in genomic research enrollment Open
PURPOSE: Persistent inequities in genomic medicine and research contribute to health disparities. This analysis uses a context-specific and equity-focused strategy to evaluate enrollment patterns for Genomic Answers for Kids (GA4K), a larg…
View article: Variation in antibiotic resistance patterns for children and adults treated at 166 non-affiliated US facilities using EHR data
Variation in antibiotic resistance patterns for children and adults treated at 166 non-affiliated US facilities using EHR data Open
Background Antibiotic resistance (AR) is a global public health threat. Surveillance of baseline AR and trends and emerging resistance among priority bacterial isolates with respect to the age of the patients and the type of healthcare set…
View article: The use of virtual tools in narrowing the impact of health disparities in neurology
The use of virtual tools in narrowing the impact of health disparities in neurology Open
The concept of Epilepsy Treatment Gap (ETG) refers to the proportion of people with epilepsy who are not being appropriately treated. The ETG in the USA approaches 10%, with historically underserved populations and rural populations dispro…
View article: A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources
A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources Open
Objective The Genomic Medicine Working Group of the National Advisory Council for Human Genome Research virtually hosted its 13th genomic medicine meeting titled “Developing a Clinical Genomic Informatics Research Agenda”. The meeting’s go…
View article: Standardized Health data and Research Exchange (SHaRE): promoting a learning health system
Standardized Health data and Research Exchange (SHaRE): promoting a learning health system Open
Aggregate de-identified data from electronic health records (EHRs) provide a valuable resource for research. The Standardized Health data and Research Exchange (SHaRE) is a diverse group of US healthcare organizations contributing to the C…
View article: Use of large scale EHR data to evaluate A1c utilization among sickle cell disease patients
Use of large scale EHR data to evaluate A1c utilization among sickle cell disease patients Open
Background The glycated hemoglobin (A1c) test is not recommended for sickle cell disease (SCD) patients. We examine ordering patterns of diabetes-related tests for SCD patients to explore misutilization of tests among this underserved popu…
View article: Ranking Methodology to Evaluate the Severity of a Quality Gap Using a National EHR Database.
Ranking Methodology to Evaluate the Severity of a Quality Gap Using a National EHR Database. Open
Selecting quality improvement projects can often be a reactive process. In order to demonstrate a data-driven strategy, we used multi-site, de-identified electronic health record (EHR) data to prioritize the severity of a quality concern: …
View article: The Envirome Web Service: Patient context at the point of care
The Envirome Web Service: Patient context at the point of care Open
Patient context - the "envirome" - can have a significant impact on patient health. While envirome indicators are available through large scale public data sources, they are not provided in a format that can be easily accessed and interpre…
View article: Aligning EHR Data for Pediatric Leukemia With Standard Protocol Therapy
Aligning EHR Data for Pediatric Leukemia With Standard Protocol Therapy Open
PURPOSE Children with acute lymphoblastic leukemia (ALL) are treated according to risk-based protocols defined by the Children's Oncology Group (COG). Alignment between real-world clinical practice and protocol milestones is not widely und…
View article: Impact of Discoordinated Care on Healthcare Utilization and Survival in Stage IV Non-Small Cell Lung Cancer Patients
Impact of Discoordinated Care on Healthcare Utilization and Survival in Stage IV Non-Small Cell Lung Cancer Patients Open
Background Cancer patients’ treatment is often dispersed across multiple physician communities that may not exchange information. We measured the association between this type of discoordinated care and healthcare utilization, cost, and mo…
View article: Small sleepers, big data: leveraging big data to explore sleep-disordered breathing in infants and young children
Small sleepers, big data: leveraging big data to explore sleep-disordered breathing in infants and young children Open
Study Objectives Infants represent an understudied minority in sleep-disordered breathing (SDB) research and yet the disease can have a significant impact on health over the formative years of neurocognitive development that follow. Herein…
View article: 0998 Health Care Utilization of Pediatric Sleep Disorders in Cerner Health Facts Database
0998 Health Care Utilization of Pediatric Sleep Disorders in Cerner Health Facts Database Open
Introduction This study was aimed to identify health care utilization of sleep disorders in pediatrics and adults by using Cerner health facts database. Methods Health facts database has unidentified health records from all the participati…
View article: Heterogeneity introduced by EHR system implementation in a de-identified data resource from 100 non-affiliated organizations
Heterogeneity introduced by EHR system implementation in a de-identified data resource from 100 non-affiliated organizations Open
Objectives Electronic health record (EHR) data aggregated from multiple, non-affiliated, sources provide an important resource for biomedical research, including digital phenotyping. Unlike work with EHR data from a single organization, ag…
View article: Variation among Consent Forms for Clinical Whole Exome Sequencing
Variation among Consent Forms for Clinical Whole Exome Sequencing Open
The goal of this study was to explore variation among informed consent documents for clinical whole exome sequencing (WES) in order to identify the level of consistency with the recommendations from the American College of Medical Genetics…
View article: An informatics research agenda to support precision medicine: seven key areas
An informatics research agenda to support precision medicine: seven key areas Open
The recent announcement of the Precision Medicine Initiative by President Obama has brought precision medicine (PM) to the forefront for healthcare providers, researchers, regulators, innovators, and funders alike. As technologies continue…