Mark A. Randolph
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View article: Development of a 24-h Preservation Protocol of Forearm Vascularized Composite Allotransplants in Nonhuman Primates Using Subnormothermic Machine Perfusion
Development of a 24-h Preservation Protocol of Forearm Vascularized Composite Allotransplants in Nonhuman Primates Using Subnormothermic Machine Perfusion Open
Background. Subnormothermic machine perfusion shows promise as a viable alternative to static cold storage for prolonged preservation of vascularized composite allografts. To date, most studies have been conducted in nonprimate models, and…
View article: Non-invasive Resonance Raman Spectroscopy provides an early estimation of depth in a pig model of multi-depth burns
Non-invasive Resonance Raman Spectroscopy provides an early estimation of depth in a pig model of multi-depth burns Open
View article: Biochemical and Biomechanical Properties of Scaffold-Free Hyaline Cartilage Generated Under Dynamic Conditions
Biochemical and Biomechanical Properties of Scaffold-Free Hyaline Cartilage Generated Under Dynamic Conditions Open
Developing a functional tissue-engineered articular cartilage remains a challenge to improving clinical treatment of cartilage injury and joint-related degenerative disease. The dynamic self-regenerating cartilage (dSRC) approach presented…
View article: 24. Sub Normothermic Machine Perfusion in the Non-human Primate Partial Face Transplant Model: A Preliminary Study
24. Sub Normothermic Machine Perfusion in the Non-human Primate Partial Face Transplant Model: A Preliminary Study Open
View article: 99. First Case of Extended Immunosuppression-free Survival of a Face Allotransplant Via Immune Chimerism Induction the Non Human Primate Model
99. First Case of Extended Immunosuppression-free Survival of a Face Allotransplant Via Immune Chimerism Induction the Non Human Primate Model Open
View article: A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction
A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction Open
Vascularized composite allotransplantation (VCA) has emerged as a robust alternative for addressing anatomically complex defects but requires a toxic lifelong immunosuppressive regimen. Tissue engineering offers the promise of creating rec…
View article: Comparison of Photochemically Sealed Commercial Biomembranes for Nerve Regeneration
Comparison of Photochemically Sealed Commercial Biomembranes for Nerve Regeneration Open
Peripheral nerve injuries affect 13–23 per 100,000 people annually in the U.S. and often result in motor and sensory deficits. Microsurgical suture repair (SR) is the standard treatment but is technically challenging and associated with co…
View article: Dual-drug releasing PEG-PLA hydrogels with tunable degradation for sustained local analgesia and anti-inflammatory therapy in a rat fracture/osteotomy model
Dual-drug releasing PEG-PLA hydrogels with tunable degradation for sustained local analgesia and anti-inflammatory therapy in a rat fracture/osteotomy model Open
View article: 3D Printed Biomimetic Composite for Treatment of Osteochondral Defects: A Preliminary Study in Porcine
3D Printed Biomimetic Composite for Treatment of Osteochondral Defects: A Preliminary Study in Porcine Open
View article: Soluble allogeneic telocollagen as a direct protein therapeutic: results of serial injections in a rodent rotator cuff tear model
Soluble allogeneic telocollagen as a direct protein therapeutic: results of serial injections in a rodent rotator cuff tear model Open
View article: Photosealed Neurorrhaphy Using Autologous Tissue
Photosealed Neurorrhaphy Using Autologous Tissue Open
Photochemical sealing of a nerve wrap over the repair site isolates and optimizes the regenerating nerve microenvironment. To facilitate clinical adoption of the technology, we investigated photosealed autologous tissue in a rodent sciatic…
View article: VCA supercooling in a swine partial hindlimb model
VCA supercooling in a swine partial hindlimb model Open
View article: Laser Ablation Facilitates Implantation of Dynamic Self-Regenerating Cartilage for Articular Cartilage Regeneration
Laser Ablation Facilitates Implantation of Dynamic Self-Regenerating Cartilage for Articular Cartilage Regeneration Open
Objectives: This study investigated a novel strategy for improving regenerative cartilage outcomes. It combines fractional laser treatment with the implantation of neocartilage generated from autologous dynamic Self-Regenerating Cartilage …
View article: Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation
Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation Open
The current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early as after 2 h of SCS. Alternatively, machine perfusion (MP)…
View article: Exploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts
Exploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts Open
Vascularized composite allografts (VCA) face ischemic challenges due to their limited availability. Reperfusion following ischemia triggers oxidative stress and immune reactions, and scavenger molecules could mitigate ischemia–reperfusion …
View article: 133 Early Assessment of Burn Depth in a Yucatan Minipig Model Using Resonance Raman Spectroscopy
133 Early Assessment of Burn Depth in a Yucatan Minipig Model Using Resonance Raman Spectroscopy Open
Introduction Assessment of thermal burns in the acute phase is critical since healing may require surgical intervention depending on the depth of injury. Early depth estimation guides debridement and planning care strategy. Current assessm…
View article: 103. Extended VCA Preservation Using Supercooling In A Pig Model
103. Extended VCA Preservation Using Supercooling In A Pig Model Open
Purpose: Vascularized Composite Allografts (VCAs) typically have a restricted storage timeframe of 4-6 hours due to the vulnerability of muscle tissue to ischemia. The application of supercooling techniques has demonstrated promising outco…
View article: Optimized Decellularization of a Porcine Fasciocutaneaous Flap
Optimized Decellularization of a Porcine Fasciocutaneaous Flap Open
Reconstructive techniques to repair severe tissue defects include the use of autologous fasciocutaneous flaps, which may be limited due to donor site availability or lead to complications such as donor site morbidity. A number of synthetic…
View article: The efficacy of vitamin E in preventing arthrofibrosis after joint replacement
The efficacy of vitamin E in preventing arthrofibrosis after joint replacement Open
Background Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint tissues. Vitamin E is an antioxidant with potential anti‐fibroblastic effect. The aim of this study was to establish an arthrofibrosis rat…
View article: Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions Open
Background Despite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of patients with advanced clear cell renal cell carcinoma (ccRCC) present with bone metastasis…
View article: The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization
The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization Open
Autonomization is a physiological process allowing a flap to develop neo-vascularization from the reconstructed wound bed. This phenomenon has been used since the early application of flap surgeries but still remains poorly understood. Rec…
View article: Towards Optimizing Sub-Normothermic Machine Perfusion in Fasciocutaneous Flaps: A Large Animal Study
Towards Optimizing Sub-Normothermic Machine Perfusion in Fasciocutaneous Flaps: A Large Animal Study Open
Machine perfusion has developed rapidly since its first use in solid organ transplantation. Likewise, reconstructive surgery has kept pace, and ex vivo perfusion appears as a new trend in vascularized composite allotransplants preservation…
View article: A longitudinal rat model for assessing postoperative recovery and bone healing following tibial osteotomy and plate fixation
A longitudinal rat model for assessing postoperative recovery and bone healing following tibial osteotomy and plate fixation Open
View article: Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts
Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts Open
Ex vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in favor of substantia…
View article: Gelatin methacryloyl hydrogel with and without dental pulp stem cells for <scp>TMJ</scp> regeneration: An in vivo study in rabbits
Gelatin methacryloyl hydrogel with and without dental pulp stem cells for <span>TMJ</span> regeneration: An in vivo study in rabbits Open
Background In the last decade, tissue‐engineering strategies for regenerating the temporomandibular joint (TMJ) have been investigated. This may be a promising strategy for the minimally invasive restoration of joint integrity. Objectives …
View article: Photochemical Tissue Bonding of Amnion Allograft Membranes for Peripheral Nerve Repair: A Biomechanical Analysis
Photochemical Tissue Bonding of Amnion Allograft Membranes for Peripheral Nerve Repair: A Biomechanical Analysis Open
Background Photochemical tissue bonding (PTB) is a technique for peripheral nerve repair in which a collagenous membrane is bonded around approximated nerve ends. Studies using PTB with cryopreserved human amnion have shown promising resul…
View article: Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo
Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo Open
The identity and origin of the stem/progenitor cells for adult joint cartilage repair remain unknown, impeding therapeutic development. Simulating the common therapeutic modality for cartilage repair in humans, i.e., full-thickness microfr…
View article: The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression
The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression Open
Myelodysplastic syndromes (MDSs) are a heterogenous group of diseases affecting the hematopoietic stem cell that are curable only by stem cell transplantation. Both hematopoietic cell intrinsic changes and extrinsic signals from the bone m…
View article: Modified Tail Vein and Penile Vein Puncture for Blood Sampling in the Rat Model
Modified Tail Vein and Penile Vein Puncture for Blood Sampling in the Rat Model Open
Blood samples are required in most experimental animal designs to assess various hematological parameters. This paper presents two procedures for blood collection in rats: the lateral tail vein puncture and the dorsal penile vein puncture,…
View article: 121. Acellular Subnomothermic Machine Perfusion of Fasciocutaneous Flaps in Swine
121. Acellular Subnomothermic Machine Perfusion of Fasciocutaneous Flaps in Swine Open
PURPOSE: Fasciocutaneous free flaps (FFF) have become one of the most advanced techniques for various defect reconstructions not treatable by a local flap. Workable vessels close to the defect are needed to allow the transfer, and failure …