Mark A. Ware
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View article: Canadian Adaptation of REVEAL(OT) for Chronic Pain Management: Rapid Qualitative Analysis Results
Canadian Adaptation of REVEAL(OT) for Chronic Pain Management: Rapid Qualitative Analysis Results Open
Background. Chronic pain brings on many lifestyle changes. Redesign your Everyday Activities and Lifestyle with Occupational Therapy (REVEAL(OT)) is an evidence-based Danish intervention that benefits the daily functioning of individuals l…
View article: Biological markers and psychosocial factors predict chronic pain conditions
Biological markers and psychosocial factors predict chronic pain conditions Open
Chronic pain is a multifactorial condition presenting significant diagnostic and prognostic challenges. Biomarkers for the classification and the prediction of chronic pain are therefore critically needed. Here, in this multidataset study …
View article: Thiabendazole as a Therapeutic Root Flare Injection for Beech Leaf Disease Management
Thiabendazole as a Therapeutic Root Flare Injection for Beech Leaf Disease Management Open
Background Thiabendazole (TBZ) has long been used in the arboricultural industry for tree injections as a key management tool of Dutch elm disease and sycamore anthracnose. This active ingredient is systemically distributed throughout the …
View article: A Biomarker-Based Framework for the Prediction of Future Chronic Pain
A Biomarker-Based Framework for the Prediction of Future Chronic Pain Open
Chronic pain is a multifactorial condition presenting significant diagnostic and prognostic challenges. Biomarkers for the classification and the prediction of chronic pain are therefore critically needed. In this multi-dataset study of ov…
View article: A Biomarker-Centric Framework for the Prediction of Future Chronic Pain
A Biomarker-Centric Framework for the Prediction of Future Chronic Pain Open
Chronic pain is a multifactorial condition presenting significant diagnostic and prognostic challenges. Biomarkers for the classification and the prediction of chronic pain are therefore critically needed. In this multi-dataset study of ov…
View article: Medical Cannabis Use Among Canadian Veterans and Non-Veterans: A National Survey
Medical Cannabis Use Among Canadian Veterans and Non-Veterans: A National Survey Open
We found important differences in user characteristics and cannabis use patterns between Canadian Veterans and non-Veterans. Further controlled studies are required to validate these findings, but these data suggest that orally administere…
View article: An audit of patients currently using legally acquired cannabis as a means of managing chronic pain
An audit of patients currently using legally acquired cannabis as a means of managing chronic pain Open
Introduction: Chronic pain constitutes a significant challenge to healthcare today. In Canada, it is estimated that it costs healthcare over $6 billion per year. This audit investigates the medically approved use of cannabis in the treatme…
View article: The Quebec Cannabis Registry: Investigating the Safety and Effectiveness of Medical Cannabis
The Quebec Cannabis Registry: Investigating the Safety and Effectiveness of Medical Cannabis Open
Objective: To investigate the safety and effectiveness of medical cannabis (MC) in the real-world clinical practice setting. Design: A 4-year prospective noncomparative registry of adult patients who initiated MC for a variety of indicatio…
View article: Serum Markers of Bone Turnover Following Controlled Administration of Two Medical Cannabis Products in Healthy Adults
Serum Markers of Bone Turnover Following Controlled Administration of Two Medical Cannabis Products in Healthy Adults Open
Introduction: Cannabidiol (CBD) has been shown to maintain bone integrity in pre-clinical models, but little is known about the effects of delta-9-tetrahydrocannabinol (THC) on bone turnover. In this study we explored the effects of two or…
View article: Effectiveness and Tolerability of Dronabinol Use in Patients with Chronic Pain: A Retrospective Analysis of 12-Week Open-Label Real-World Data Provided by the German Pain e-Registry
Effectiveness and Tolerability of Dronabinol Use in Patients with Chronic Pain: A Retrospective Analysis of 12-Week Open-Label Real-World Data Provided by the German Pain e-Registry Open
Objective To evaluate the effectiveness of Δ9-tetrahydrocannabinol (dronabinol [DRO]) as an add-on treatment in patients with refractory chronic pain (CP). Methods An exploratory retrospective analysis of 12-week data provided by the Germa…
View article: Six-month outcomes of an integrated primary care prevention and management program for chronic low back pain (LBP)
Six-month outcomes of an integrated primary care prevention and management program for chronic low back pain (LBP) Open
Background Accessible interdisciplinary, patient-centered and integrated primary care programs for chronic pain are needed for averting chronicity and improving patient outcomes. We sought 1) to develop an interdisciplinary low back pain (…
View article: Longitudinal Relationship between the Introduction of Medicinal Cannabis and Polypharmacy: An Australian Real‐World Evidence Study
Longitudinal Relationship between the Introduction of Medicinal Cannabis and Polypharmacy: An Australian Real‐World Evidence Study Open
Background . Recent studies recommend medicinal cannabis (MC) as a potential treatment for chronic pain (CP) when conventional therapies are not successful; however, data from Australia is limited. This real‐world evidence study explored h…
View article: Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials
Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials Open
Objective To determine the benefits and harms of medical cannabis and cannabinoids for chronic pain. Design Systematic review and meta-analysis. Data sources MEDLINE, EMBASE, AMED, PsycInfo, CENTRAL, CINAHL, PubMed, Web of Science, Cannabi…
View article: Cannabinoid Profiles in Medical Cannabis Users: Effects of Age, Gender, Symptoms, and Duration of Use
Cannabinoid Profiles in Medical Cannabis Users: Effects of Age, Gender, Symptoms, and Duration of Use Open
Introduction: Clinical trials remain the gold standard for evaluating efficacy, but there is increasing interest in using real-world evidence (RWE) to inform health care decision making. The aims of this observational study were to describ…
View article: Authorization Patterns, Safety, and Effectiveness of Medical Cannabis in Quebec
Authorization Patterns, Safety, and Effectiveness of Medical Cannabis in Quebec Open
Introduction: Despite increasing demand for data, little is known about the authorization patterns, safety, and effectiveness of medical cannabis products. Materials and Methods: We conducted a 2 year observational study of adult patients …
View article: Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Red Softgels in Healthy Participants
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Red Softgels in Healthy Participants Open
Due to a lack of published pharmacokinetic (PK) and/or pharmacodynamic (PD) data, informed physician and patient decision-making surrounding appropriate dosing of cannabis for medical purposes is limited. This Phase 1, multiple-dose study …
View article: Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants Open
Due to a lack of published pharmacokinetic (PK) and/or pharmacodynamic (PD) data, decision-making surrounding appropriate dosing of cannabis used for medical purposes is limited. This multiple-dose study evaluated the safety, tolerability,…
View article: Cannabis against chronic musculoskeletal pain: A scoping review on users and their perceptions
Cannabis against chronic musculoskeletal pain: A scoping review on users and their perceptions Open
Background Chronic musculoskeletal pain (CMP) may lead to reduced physical function and is the most common cause of chronic non cancer pain. Currently, the pharmacotherapeutic options against CMP are limited and frequently consist of pain …
View article: Cannabis against chronic muskuloskeletal pain: A scoping review on users and their perceptions
Cannabis against chronic muskuloskeletal pain: A scoping review on users and their perceptions Open
Background Chronic musculoskeletal pain (CMP) may lead to reduced physical function and is the most common cause of chronic non cancer pain. Currently, the pharmacotherapeutic options against CMP are limited and mainly consist of pain mana…
View article: Clinical Profiles of Concurrent Cannabis Use in Chronic Pain: A CHOIR Study
Clinical Profiles of Concurrent Cannabis Use in Chronic Pain: A CHOIR Study Open
Objective Despite evidence of the analgesic benefits of cannabis, there remains a relative scarcity of research on the short- and long-term effects of cannabis use in individuals with chronic pain. Design The current study is a secondary a…
View article: The Quebec Low Back Pain Study: a protocol for an innovative 2-tier provincial cohort
The Quebec Low Back Pain Study: a protocol for an innovative 2-tier provincial cohort Open
Introduction: The neurobiological mechanisms underlying recovery from or persistence of low back pain (LBP) remain misunderstood, limiting progress toward effective management. We have developed an innovative two-tier design to study the t…
View article: Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis
Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis Open
We observed an independent negative association between frequent cannabis use and frequent illicit opioid use among PWUD with chronic pain. These findings provide longitudinal observational evidence that cannabis may serve as an adjunct to…
View article: <p>Determinants Of Patient Experience With Low Back Pain Interdisciplinary Care: A Pre-Post Interventional Study</p>
Determinants Of Patient Experience With Low Back Pain Interdisciplinary Care: A Pre-Post Interventional Study Open
The lack of association of hypothesized determinants requires further examination of the properties of the PACIC and with a larger sample. Future investigation is needed on the relationship between improved patient experience and outcomes.
View article: Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood
Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood Open
Although individual-level risk remains moderate to low and results from this study should be confirmed in future adequately powered prospective studies, the high prevalence of adolescents consuming cannabis generates a large number of youn…