Mark A. Warner
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Methods to study xenografted human cancer in genetically diverse mice Open
Xenografting human cancer tissues into mice to test new cures against cancers is critical for understanding and treating the disease. However, only a few inbred strains of mice are used to study cancers, and derivatives of mainly one strai…
David O. Warner, M.D., Recipient of the 2022 Excellence in Research Award Open
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View article: Genetically diverse mouse platform to xenograft cancer cells
Genetically diverse mouse platform to xenograft cancer cells Open
The lack of genetically diverse preclinical animal models in basic biology and efficacy testing has been cited as a potential cause of failure in clinical trials. We developed and characterized five diverse RAG1 null mouse strains as model…
The Evolution of the Anesthesia Patient Safety Movement in America: Lessons Learned and Considerations to Promote Further Improvement in Patient Safety Open
Ellison C. Pierce, Jr., M.D., and a small number of specialty leaders and scientists formed a remarkable, diverse team in the mid-1980s to address a dual crisis: a safety crisis for anesthetized patients and a medical malpractice insurance…
Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis Open
Background Perioperative pulmonary aspiration of gastric contents has been associated with severe morbidity and death. The primary aim of this study was to identify outcomes and patient and process of care risk factors associated with gast…
Anesthetic Considerations for Angelman Syndrome: Case Series and Review of the Literature Open
Angelman syndrome patients often require anesthesia for relatively innocuous procedures, and their speech impairment and happy demeanor can confound postoperative pain assessment. Patients can have atypical responses to benzodiazepines. Cr…