Mark B. Abelson
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View article: Statistical Evaluation of Smartphone-Based Automated Grading System for Ocular Redness Associated with Dry Eye Disease and Implications for Clinical Trials
Statistical Evaluation of Smartphone-Based Automated Grading System for Ocular Redness Associated with Dry Eye Disease and Implications for Clinical Trials Open
This study demonstrates that fully automating image analysis allows thousands of images to be graded efficiently. The addition of the horizontality parameter enhances model performance, reduces error, and supports its relevance to specific…
View article: Advantages of Lissamine Green Vital Staining as an Endpoint in Dry Eye Clinical Trials
Advantages of Lissamine Green Vital Staining as an Endpoint in Dry Eye Clinical Trials Open
This evaluation demonstrates the superiority of the utilization of a clinical endpoint focused on ocular surface damage. The reproducibility and modifiability of LG conjunctival staining to controlled adverse environment, coupled with its …
View article: <p>Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function</p>
Early Ophthalmic Changes in Macula Does Not Correlate with Visual Function Open
A panel of psychophysical tests did not demonstrate significant differences between subjects with and without minimal macular changes.
View article: An Alternative Psychophysical Diagnostic Indicator of the Aging Eye
An Alternative Psychophysical Diagnostic Indicator of the Aging Eye Open
Purpose . Impaired adaptation to changes in lighting levels as well as mesopic visual function is a common complaint in those over the age of 65. The use of photostress is a well-established method to test the adaption rate and the respons…
View article: <p>Iodixanol nasal solution reduces allergic rhinoconjunctivitis signs and symptoms in Allergen BioCube<sup>&reg;</sup>:&nbsp;a randomized clinical trial</p>
Iodixanol nasal solution reduces allergic rhinoconjunctivitis signs and symptoms in Allergen BioCube<sup>®</sup>: a randomized clinical trial Open
NCT02377895.
View article: Cone photoreceptor macular function and recovery after photostress in early non-exudative age-related macular degeneration
Cone photoreceptor macular function and recovery after photostress in early non-exudative age-related macular degeneration Open
The baseline cone threshold shows potential as a novel parameter to assess visual dysfunction in early AMD. This outcome consistently detected deficits in AMD subjects, and differentiated them from age-matched controls with high test-retes…
View article: Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review
Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review Open
Article full text The full text of this article can be found here. https://link.springer.com/article/10.1007/s40123-017-0110-x Provide enhanced content for this article If you are an author of this publication and would like to provide …
View article: Technical and clinical validation of the Allergen BioCube<sup>®</sup> for timothy grass
Technical and clinical validation of the Allergen BioCube<sup>®</sup> for timothy grass Open
Introduction Field studies for allergic rhinitis (AR) commonly have inconsistent allergen concentrations and subject exposure patterns due to varying environmental conditions and subject behaviors. A technical and clinical validation study…
View article: Technical and clinical validation of an environmental exposure unit for ragweed
Technical and clinical validation of an environmental exposure unit for ragweed Open
The Allergen BioCube achieved technical and clinical validation for ragweed allergen. Ragweed pollen concentration was uniform both temporally and spatially. Allergic rhinitis signs and symptoms were induced in subjects during exposure to …