Mario Moisés Álvarez
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View article: One-step generation of luminescent core-shell microspheres for cell encapsulation via pulsed operation in centrifugal microfluidics
One-step generation of luminescent core-shell microspheres for cell encapsulation via pulsed operation in centrifugal microfluidics Open
Biopolymer core-shell microspheres play a crucial role in various biomedical applications, including drug delivery, tissue engineering, and diagnostics. These applications require microparticles with consistent, well-controlled size and pr…
View article: Monte Carlo algorithm for calculating pre-neutron fragment mass and kinetic energy distributions from measurements using the 2E Technique for reaction 235U(nth,f)
Monte Carlo algorithm for calculating pre-neutron fragment mass and kinetic energy distributions from measurements using the 2E Technique for reaction 235U(nth,f) Open
A nuclear fission event of an actinide results in the formation of two complementary primary fragments with masses (A, A'), which subsequently acquire kinetic energies (E, E') due to Coulomb repulsion. Following this, they emit (n, n') pro…
View article: Chaotic Direct Ink Writing (ChDIW) of Hybrid Hydrogels: Implication for Fabrication of Micro‐ordered Multifunctional Cryogels
Chaotic Direct Ink Writing (ChDIW) of Hybrid Hydrogels: Implication for Fabrication of Micro‐ordered Multifunctional Cryogels Open
The modern era demands multifunctional materials to support advanced technologies and tackle complex environmental issues caused by these innovations. Consequently, material hybridization has garnered significant attention as a strategy to…
View article: Collaborative Heterogeneous Mini-Robotic 3D Printer for Manufacturing Complex Food Structures with Multiple Inks and Curved Deposition Surfaces
Collaborative Heterogeneous Mini-Robotic 3D Printer for Manufacturing Complex Food Structures with Multiple Inks and Curved Deposition Surfaces Open
The necessity of developing more realistic artificial food requires the aggregation of different biomaterials in an ordered and controlled manner. One of the most advanced methods for this is food printers reproducing additive manufacturin…
View article: Chaos‐Assisted Production of Micro‐Architected Spheres (CAPAS)
Chaos‐Assisted Production of Micro‐Architected Spheres (CAPAS) Open
Hydrogel droplets with inner compartments are valuable in various fields, including tissue engineering. A droplet‐based biofabrication method is presented for the chaos‐assisted production of architected spheres (CAPAS) for the rapid gener…
View article: Light-based and cost-effective bioprinting of musculoskeletal GelMA constructs enriched with mesoporous bioactive glass nanoparticles
Light-based and cost-effective bioprinting of musculoskeletal GelMA constructs enriched with mesoporous bioactive glass nanoparticles Open
Bioprinting represents a promising technique for fabricating three-dimensional (3D) constructs with high-resolution and controlled architecture. However, many bioprinting technologies rely on expensive extrusion systems, which may compromi…
View article: A 3D-printed tumor-on-chip: user-friendly platform for the culture of breast cancer spheroids and the evaluation of anti-cancer drugs
A 3D-printed tumor-on-chip: user-friendly platform for the culture of breast cancer spheroids and the evaluation of anti-cancer drugs Open
Tumor-on-chips (ToCs) are useful platforms for studying the physiology of tumors and evaluating the efficacy and toxicity of anti-cancer drugs. However, the design and fabrication of a ToC system is not a trivial venture. We introduce a us…
View article: Comprehensive sustainable development of a multifunctional machine: 3D food printer and didactic platform
Comprehensive sustainable development of a multifunctional machine: 3D food printer and didactic platform Open
The development of machines explores the development of a manufacturing system. This perspective offers challenges adjacent to the materials, the product that wants to be manufactured, the technical considerations that must be covered duri…
View article: Simulation of the 2E Technique on neutron multiplicity measurement as a function of fragment mass in spontaneous fission of 252Cf
Simulation of the 2E Technique on neutron multiplicity measurement as a function of fragment mass in spontaneous fission of 252Cf Open
A Monte Carlo simulation algorithm to investigate the measurement of the average prompt neutron multiplicity as a function of pre-neutron mass, ν(A), for fragments from the spontaneous fission of 252Cf is presented. The input data consist …
View article: BoLD: Fast and Cheap Dispute Resolution
BoLD: Fast and Cheap Dispute Resolution Open
BoLD is a new dispute resolution protocol that is designed to replace the originally deployed Arbitrum dispute resolution protocol. Unlike that protocol, BoLD is resistant to delay attacks. It achieves this resistance without a significant…
View article: Together but not scrambled: A perspective on chaotic printing/bioprinting
Together but not scrambled: A perspective on chaotic printing/bioprinting Open
Structures in nature are often multi‐material, and their structures have a fine balance between segregation and aggregation (mixed, but not scrambled) that provides functionality. Chaotic fabrication, a technology that exploits the ability…
View article: Continuous inline monitoring of glucose in an organ-on-chip using FreeStyle™ libre glucometers
Continuous inline monitoring of glucose in an organ-on-chip using FreeStyle™ libre glucometers Open
Introduction: Organ-on-chips have become an effective platform for studying the physiology of tissues and organs and for evaluating the safety and efficacy of drugs. In these systems, the inline monitoring of key parameters of biological p…
View article: Self-Diagnosis of SARS-CoV-2 from Saliva Samples at Home: Isothermal Amplification Enabled by Do-It-Yourself Portable Incubators and Laminated Poly-ethyl Sulfonate Membranes
Self-Diagnosis of SARS-CoV-2 from Saliva Samples at Home: Isothermal Amplification Enabled by Do-It-Yourself Portable Incubators and Laminated Poly-ethyl Sulfonate Membranes Open
COVID-19 made explicit the need for rethinking the way in which we conduct testing for epidemic emergencies. During the COVID-19 pandemic, the dependence on centralized lab facilities and resource-intensive methodologies (e.g., RT-qPCR met…
View article: Monte Carlo algorithm for calculating pre-neutron fragment mass and kinetic energy distributions from measurements using the 2E Technique for reaction 235U(nth, f)
Monte Carlo algorithm for calculating pre-neutron fragment mass and kinetic energy distributions from measurements using the 2E Technique for reaction 235U(nth, f) Open
An algorithm is proposed that enables the calculation of pre-neutron mass and energy distributions of fission fragments from uranium-235, induced by thermal neutrons, utilizing measurements obtained through the 2E technique. This algorithm…
View article: Development of an affordable extrusion 3D bioprinter equipped with a temperature-controlled printhead
Development of an affordable extrusion 3D bioprinter equipped with a temperature-controlled printhead Open
Bioprinters show great promise as enablers of regenerative medicine and other biomedical engineering applications. In this work, we present a flexible and cost-effective design for a do-it-yourself bioprinter capable of printing/bioprintin…
View article: Placing biofabrication into the context of human disease modeling
Placing biofabrication into the context of human disease modeling Open
The field of biofabrication has seen tremendous advances in the past decade. More recently, the emerging role of biofabrication in allowing faithful generation of models of human tissues in their healthy and diseased states has been demons…
View article: 3D-Printed Tumor-on-Chip for the Culture of Colorectal Cancer Microspheres: Mass Transport Characterization and Anti-Cancer Drug Assays
3D-Printed Tumor-on-Chip for the Culture of Colorectal Cancer Microspheres: Mass Transport Characterization and Anti-Cancer Drug Assays Open
Tumor-on-chips have become an effective resource in cancer research. However, their widespread use remains limited due to issues related to their practicality in fabrication and use. To address some of these limitations, we introduce a 3D-…
View article: Gelatin-methacryloyl hydrogels containing turnip mosaic virus for fabrication of nanostructured materials for tissue engineering
Gelatin-methacryloyl hydrogels containing turnip mosaic virus for fabrication of nanostructured materials for tissue engineering Open
Current tissue engineering techniques frequently rely on hydrogels to support cell growth, as these materials strongly mimic the extracellular matrix. However, hydrogels often need ad hoc customization to generate specific tissue construct…
View article: Bubble-Patterned Films by Inkjet Printing and Gas Foaming
Bubble-Patterned Films by Inkjet Printing and Gas Foaming Open
The micropatterning of thin films represents a challenging task, even for additive manufacturing techniques. In this work, we introduce the use of inkjet-printing technology coupled with a gas-foaming process, to produce patterned porositi…
View article: Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies
Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies Open
The use of organoids has become increasingly popular recently due to their self-organizing abilities, which facilitate developmental and disease modeling. Various methods have been described to create embryoid bodies (EBs) generated from e…
View article: Fabrication of Maize-Based Nanoparticles at Home: A Research-Based Learning Activity
Fabrication of Maize-Based Nanoparticles at Home: A Research-Based Learning Activity Open
Nanotechnology is an interdisciplinary field that promises to reshape many spheres of our lives. One core activity in nanotechnology is the synthesis of nanoparticles. Here, we introduce a research-based activity centered on the use of zei…
View article: nurP28, a New-to-Nature Zein-Derived Peptide, Enhances the Therapeutic Effect of Docetaxel in Breast Cancer Monolayers and Spheroids
nurP28, a New-to-Nature Zein-Derived Peptide, Enhances the Therapeutic Effect of Docetaxel in Breast Cancer Monolayers and Spheroids Open
The development of novel cancer therapeutic strategies has garnered increasing interest in cancer research. Among the therapeutic choices, chemosensitizers have shown exciting prospects. Peptides are an attractive alternative among the mol…
View article: Retrofitting of an Affordable 3D Printer: Towards a Material Efficient and Low-Cost Bioprinting System
Retrofitting of an Affordable 3D Printer: Towards a Material Efficient and Low-Cost Bioprinting System Open
3D bioprinting is an emerging technique employed for engineering complex structures that can be used for regenerative medicine. Extrusion of hydrogels through a nozzle has produced layer by layer designs towards engineering patterns. Despi…
View article: Chaotic printing of hydrogel carriers for human mesenchymal stem cell expansion
Chaotic printing of hydrogel carriers for human mesenchymal stem cell expansion Open
Increasing expansion rate in cell manufacturing systems would allow faster delivery of life-saving treatments to a greater number of patients. Chaotic printing is a novel biofabrication technology that could improve cell expansion capabili…
View article: Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies
Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies Open
The use of organoids has become increasingly popular recently due to their self-organizing abilities, which facilitate developmental and disease modeling. Various methods have been described to create embryoid bodies (EBs) generated from e…
View article: Portable and Label-Free Quantitative Loop-Mediated Isothermal Amplification (LF-qLamp) for Reliable COVID-19 Diagnostics in Three Minutes of Reaction Time: Arduino-Based Detection System Assisted by a pH Microelectrode
Portable and Label-Free Quantitative Loop-Mediated Isothermal Amplification (LF-qLamp) for Reliable COVID-19 Diagnostics in Three Minutes of Reaction Time: Arduino-Based Detection System Assisted by a pH Microelectrode Open
Loop-mediated isothermal amplification (LAMP) has been recently studied as an alternative method for cost-effective diagnostics in the context of the current COVID-19 pandemic. Recent reports document that LAMP-based diagnostic methods hav…