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View article: Quantification of [<sup>11</sup>C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations
Quantification of [<sup>11</sup>C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations Open
Introduction: In vitro data from primates provide conflicting evidence about the suitability of the cerebellum as a reference region for quantifying type 5 metabotropic glutamate receptor (mGluR5) binding parameters with positron emission …
View article: Quantification of [<sup>11</sup>C]ABP688 binding in human brain using cerebellum as reference region: biological interpretation and limitations
Quantification of [<sup>11</sup>C]ABP688 binding in human brain using cerebellum as reference region: biological interpretation and limitations Open
In vitro data from primates provide conflicting evidence about the cerebellum’s suitability as a reference region for quantifying type 5 metabotropic glutamate receptor (mGluR5) binding parameters with positron emission tomography (PET). T…
View article: Author Response: Functional Outcomes and Mortality in Patients With Intracerebral Hemorrhage After Intensive Medical and Surgical Support
Author Response: Functional Outcomes and Mortality in Patients With Intracerebral Hemorrhage After Intensive Medical and Surgical Support Open
We thank Drs. Shah, Carhuapoma, Hanley, and Ziai for their comments. Our study is an analysis of intracerebral hemorrhage (ICH) outcomes in a real-world setting.1 We agree that it should inform, not determine current practice, much as did …
View article: Functional Outcomes and Mortality in Patients With Intracerebral Hemorrhage After Intensive Medical and Surgical Support
Functional Outcomes and Mortality in Patients With Intracerebral Hemorrhage After Intensive Medical and Surgical Support Open
This study demonstrates that poor outcomes after ICH prevail despite aggressive treatment. Unfavorable outcomes appear related to direct effects of the primary injury and not to premature care limitations. Lifesaving surgery for supratento…
View article: Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal
Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal Open
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage continues to be associated with high levels of morbidity and mortality. This complication had long been thought to occur secondary to severe cerebral vasospasm, b…
View article: Intravenous Milrinone Salvage Therapy in Acute Internal Carotid Artery Occlusion: Case Report
Intravenous Milrinone Salvage Therapy in Acute Internal Carotid Artery Occlusion: Case Report Open
View article: The future of non-invasive cerebral oximetry in neurosurgical procedures: A systematic review
The future of non-invasive cerebral oximetry in neurosurgical procedures: A systematic review Open
Background:Cerebral hypoxia is one of the most important causes of secondary brain injury during neurosurgical procedures and in neurointensive care. In patients with brain injury, cerebrovascular reactivity may be impaired and a decrease …
View article: Early abnormal transient hyperemic response test can predict delayed ischemic neurologic deficit in subarachnoid hemorrhage
Early abnormal transient hyperemic response test can predict delayed ischemic neurologic deficit in subarachnoid hemorrhage Open
View article: CT Perfusion to Guide Placement of Invasive Cerebral Perfusion Monitor in Subarachnoid Hemorrhage Induced Vasospasm
CT Perfusion to Guide Placement of Invasive Cerebral Perfusion Monitor in Subarachnoid Hemorrhage Induced Vasospasm Open
Background . Vasospasm is a challenging component of the subarachnoid hemorrhage “syndrome” that is unpredictable and very difficult to monitor using noninvasive or invasive monitoring technologies in neurocritical units. Methods. We descr…
View article: E.03 Use of intra-arterial milrinone rescue therapy in patients with refractory and super refractory vasospasm after aneurysmal subarachnoid hemorrhage
E.03 Use of intra-arterial milrinone rescue therapy in patients with refractory and super refractory vasospasm after aneurysmal subarachnoid hemorrhage Open
Background: Vasospasm causing delayed ischemic neurologic deficit (DIND) remains a leading cause of devastating outcome after aneurysmal subarachnoid hemorrhage (aSAH). Therapy using intravenous milrinone (IVM) and intra-arterial milrinone…
View article: Clinical outcome prediction in aneurysmal subarachnoid hemorrhage - Alterations in brain-body interface
Clinical outcome prediction in aneurysmal subarachnoid hemorrhage - Alterations in brain-body interface Open
Using the aforementioned results generated from binary logistic regression models, we can identify potential patients who are in the high risk group of neurological deterioration. Specific therapies can be tailored to prevent these detrime…
View article: Aneurysmal subarachnoid hemorrhage prognostic decision-making algorithm using classification and regression tree analysis
Aneurysmal subarachnoid hemorrhage prognostic decision-making algorithm using classification and regression tree analysis Open
A clinically useful classification tree was generated, which serves as a prediction tool to guide bedside prognostication and clinical treatment decision making. This prognostic decision-making algorithm also shed light on the complex inte…