Mark C. Bagley
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View article: Synthesis of Core‐Functionalised Naphthalenediimides from Naphthalenetetracarboxylic Dianhydride using a Vibratory Ball Mill: Bromination, Imidization and Heck‐Type Reactions
Synthesis of Core‐Functionalised Naphthalenediimides from Naphthalenetetracarboxylic Dianhydride using a Vibratory Ball Mill: Bromination, Imidization and Heck‐Type Reactions Open
The synthesis of 9 core‐functionalised naphthalene diimide (c‐NDI) residues is reported via a 3‐step synthesis from naphthalenetetracarboxylic dianhydride using only mechanochemical activation. Selective dibromination and subsequent diimid…
View article: CCDC 2159473: Experimental Crystal Structure Determination
CCDC 2159473: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2159474: Experimental Crystal Structure Determination
CCDC 2159474: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and Evaluation of a Silver Nanoparticle/Polyurethane Composite That Exhibits Antiviral Activity against SARS-CoV-2
Synthesis and Evaluation of a Silver Nanoparticle/Polyurethane Composite That Exhibits Antiviral Activity against SARS-CoV-2 Open
In this proof-of-concept study, we aim to produce a polyurethane (PU)-based composite that can reduce the amount of viable SARS-CoV-2 virus in contact with the surface of the polymeric film without further interventions such as manual clea…
View article: A Convenient, Rapid, Conventional Heating Route to MIDA Boronates
A Convenient, Rapid, Conventional Heating Route to MIDA Boronates Open
A cheap, conventional, sealed heating reactor proved to be a useful alternative to a microwave reactor in the synthesis of a >20-member MIDA boronate library (MIDA = N-methyliminodiacetic acid). Reaction times were 10 min and work-ups were…
View article: Solvent‐Free Synthesis of Core‐Functionalised Naphthalene Diimides by Using a Vibratory Ball Mill: Suzuki, Sonogashira and Buchwald–Hartwig Reactions
Solvent‐Free Synthesis of Core‐Functionalised Naphthalene Diimides by Using a Vibratory Ball Mill: Suzuki, Sonogashira and Buchwald–Hartwig Reactions Open
Solvent‐free synthesis by using a vibratory ball mill (VBM) offers the chance to access new chemical reactivity, whilst reducing solvent waste and minimising reaction times. Herein, we report the core functionalisation of N , N ’‐bis(2‐eth…
View article: Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds
Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds Open
The pentafluorosulfanyl (‐SF 5 ) functional group is of increasing interest as a bioisostere in medicinal chemistry. A library of SF 5 ‐containing compounds, including amide, isoxazole, and oxindole derivatives, was synthesised using a ran…
View article: Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells
Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells Open
The carbazole compounds PK9320 (1-(9-ethyl-7-(furan-2-yl)-9H-carbazol-3-yl)-N-methylmethanamine) and PK9323 (1-(9-ethyl-7-(thiazol-4-yl)-9H-carbazol-3-yl)-N-methylmethanamine), second-generation analogues of PK083 (1-(9-ethyl-9H-carbazol-3…
View article: Recent developments in chemical reactivity of N,N-dimethylenamino ketones as synthons for various heterocycles
Recent developments in chemical reactivity of N,N-dimethylenamino ketones as synthons for various heterocycles Open
This review demonstrates the high number of synthetic applications of enaminones in the preparation of acyclic, carbocyclic, heterocyclic and fused heterocyclic compounds.
View article: 'Making' A Statement - Exploration of 3D Printing Technologies as a form of Customisation and Ownership in Urban Spaces
'Making' A Statement - Exploration of 3D Printing Technologies as a form of Customisation and Ownership in Urban Spaces Open
Ownership of urban space has been heavily contested in recent years by prominent artists, policy-makers and citizens alike. From Shephard Fairey and his condemnation of corporate culture in public space, to Banksy and his use of imagery as…
View article: Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor
Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor Open
Background and Purpose Flecainide is a use‐dependent blocker of cardiac Na + channels. Mechanistic analysis of this block showed that the cationic form of flecainide enters the cytosolic vestibule of the open Na + channel. Flecainide is al…
View article: Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts
Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts Open
Progeroid syndromes show features of accelerated ageing and are used as models for human ageing, of which Werner syndrome (WS) is one of the most widely studied. WS fibroblasts show accelerated senescence that may result from p38 MAP kinas…