Mark S. Baird
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View article: On the MCNP Forum and its Community
On the MCNP Forum and its Community Open
View article: Anthelmintic evaluation of triterpenes derived from conifers (family Pinaceae) on the digenean parasite Fasciola hepatica
Anthelmintic evaluation of triterpenes derived from conifers (family Pinaceae) on the digenean parasite Fasciola hepatica Open
Fasciolosis is a devastating food borne parasitic disease of ruminants and is mainly caused by infection with the trematode Fasciola hepatica (liver fluke) in temperate climates. The primary strategy of fasciolosis control relies on a sing…
View article: Fine-Tune an SLM or Prompt an LLM? The Case of Generating Low-Code Workflows
Fine-Tune an SLM or Prompt an LLM? The Case of Generating Low-Code Workflows Open
Large Language Models (LLMs) such as GPT-4o can handle a wide range of complex tasks with the right prompt. As per token costs are reduced, the advantages of fine-tuning Small Language Models (SLMs) for real-world applications -- faster in…
View article: A novel flow through assay and smartphone application based prototype for point-of-care diagnosis of tuberculosis
A novel flow through assay and smartphone application based prototype for point-of-care diagnosis of tuberculosis Open
Affordable point-of-care test sensors with automated result recording are essential for reducing undetected tuberculosis cases in remote, resource-limited areas. Therefore, this study addresses this need with three key aims. First, we aime…
View article: Anthelmintic Evaluation of Triterpenes Derived from Conifers (Family Pinaceae) on the Digenean Parasite Fasciola Hepatica
Anthelmintic Evaluation of Triterpenes Derived from Conifers (Family Pinaceae) on the Digenean Parasite Fasciola Hepatica Open
View article: Early antibody responses to lipid antigens in red deer infected with Mycobacterium bovis
Early antibody responses to lipid antigens in red deer infected with Mycobacterium bovis Open
ELISA using synthetic lipid antigens not only detects antibodies in the plasma of deer experimentally infected with M. bovis, but a strong response occurs early in the infection. With a full analysis of responses with naturally infected an…
View article: An ELISA Using Synthetic Mycolic Acid-Based Antigens with DIVA Potential for Diagnosing Johne’s Disease in Cattle
An ELISA Using Synthetic Mycolic Acid-Based Antigens with DIVA Potential for Diagnosing Johne’s Disease in Cattle Open
The problem: Ante-mortem diagnosis of Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is normally achieved through faecal culture, PCR, or serological tests, but agreement as to which samples are positive for …
View article: A single synthetic lipid antigen for improved serological diagnosis of Buruli ulcer
A single synthetic lipid antigen for improved serological diagnosis of Buruli ulcer Open
SETTING: The diagnosis of Buruli ulcer (BU) is frequently made by experienced health workers in rural regions. This leads to long turnaround times to confirm the diagnosis as it requires specialised laboratory infrastructure to perform con…
View article: VERAIn User's Manual 4.4
VERAIn User's Manual 4.4 Open
The Consortium for Advanced Simulation of Light Water Reactors (CASL), the first US Department of Energy (DOE) Energy Innovation Hub, was established in July 2010 to provide advanced modeling and simulation (ModSim) solutions for commercia…
View article: Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica Open
Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic p…
View article: VERA 4.3 Release Notes
VERA 4.3 Release Notes Open
The Virtual Environment for Reactor Applications (VERA) components contained in this distribution include selected computational tools and supporting infrastructure that solve neutronics, thermal hydraulics(T/H), fuel performance, ex-core …
View article: VERA Installation Guide
VERA Installation Guide Open
This guide describes the structure and setup of the standard Virtual Environment for Reactor Applications (VERA) development environment (VERA Dev Env) and standard VERA third-party libraries (TPLs) that must be in place before many of the…
View article: Flukicidal effects of abietane diterpenoid derived analogues against the food borne pathogen Fasciola hepatica.
Flukicidal effects of abietane diterpenoid derived analogues against the food borne pathogen Fasciola hepatica. Open
View article: VERAIn User's Manual
VERAIn User's Manual Open
The Consortium for Advanced Simulation of Light Water Reactors (CASL), the first US Department of Energy (DOE) Energy Innovation Hub, was established in July 2010 to provide advanced modeling and simulation (ModSim) solutions for commercia…
View article: VERA-Grizzly Ex-Core Calculations: Watts Bar Unit 1 Cycles 1-2
VERA-Grizzly Ex-Core Calculations: Watts Bar Unit 1 Cycles 1-2 Open
The critical structures that comprise light-water reactor (LWR) nuclear power plants are subjected to operating environments that can challenge their integrity. Structures in close proximity to the reactor core, such as the reactor pressur…
View article: VERA Installation Guide
VERA Installation Guide Open
This guide describes the structure and setup of the standard VERA development environment (VERA Dev Env) and standard VERA Third Party Libraries (TPLs) that need to be in place before installing many of the VERA simulation components. It d…
View article: Elevated serum antibody responses to synthetic mycobacterial lipid antigens among UK farmers: an indication of exposure to environmental mycobacteria?
Elevated serum antibody responses to synthetic mycobacterial lipid antigens among UK farmers: an indication of exposure to environmental mycobacteria? Open
Antibody binding to trehalose mycolates, such as that shown, was evaluated in ELISA. Median responses with the serum of individuals with no known mycobacterial infection were low; some were very high, the majority from Welsh farmers older …
View article: Mycobacterium alvei (ω-1)-methoxy mycolic acids: Absolute stereochemistry and synthesis
Mycobacterium alvei (ω-1)-methoxy mycolic acids: Absolute stereochemistry and synthesis Open
View article: An investigation of the antileishmanial properties of semi-synthetic saponins
An investigation of the antileishmanial properties of semi-synthetic saponins Open
Hit anti-leishmanial saponin structures selected following primary and secondary screening.
View article: Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids
Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids Open
Fragments of mycobacterial cell walls such as arabinoglycerol mycolate and dimycoloyl diarabinoglycerol, comprising complex mixtures of mycolic acids, have immunostimulatory and antigenic properties. A related di-mycoloyl tri-arabinofurano…
View article: Executive editor comment: code availability
Executive editor comment: code availability Open
View article: The synthesis of mycobacterial dimycoloyl diarabinoglycerol based on defined synthetic mycolic acids
The synthesis of mycobacterial dimycoloyl diarabinoglycerol based on defined synthetic mycolic acids Open
View article: The antigenicity and cholesteroid nature of mycolic acids determined by recombinant chicken antibodies
The antigenicity and cholesteroid nature of mycolic acids determined by recombinant chicken antibodies Open
Mycolic acids (MA) are major, species-specific lipid components of Mycobacteria and related genera. In Mycobacterium tuberculosis, it is made up of alpha-, methoxy- and keto-MA, each with specific biological functions and conformational ch…
View article: CD1b-restricted GEM T cell responses are modulated by<i>Mycobacterium tuberculosis</i>mycolic acid meromycolate chains
CD1b-restricted GEM T cell responses are modulated by<i>Mycobacterium tuberculosis</i>mycolic acid meromycolate chains Open
Significance Tuberculosis is a major global pandemic responsible for more deaths than any other infectious disease, yet no effective vaccine exists. Here, we demonstrate CD1b expression within human tuberculous granulomas, supporting a rol…
View article: New synthetic lipid antigens for rapid serological diagnosis of tuberculosis
New synthetic lipid antigens for rapid serological diagnosis of tuberculosis Open
We have identified promising antigen candidates for serological assays that could be used to diagnose PTB and which could be the basis of a much-needed, simple, rapid diagnostic test that would bring care closer to communities.
View article: The Synthesis of Single Enantiomers of α-Mycolic Acids of Mycobacterium tuberculosis and Related Organisms, with Alternative Cyclopropane Stereochemistries
The Synthesis of Single Enantiomers of α-Mycolic Acids of Mycobacterium tuberculosis and Related Organisms, with Alternative Cyclopropane Stereochemistries Open
We report the synthesis of three stereoisomers of a mycolic acid from Mycobacterium tuberculosis containing a di-cis-cyclopropane and of two stereoisomers of a mycolic acid containing a proximal trans-cyclopropane and a distal cis-cyclopro…
View article: Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages
Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages Open
The differentiation of macrophages into lipid-filled foam cells is a hallmark of the lung granuloma that forms in patients with active tuberculosis (TB). Mycolic acids (MAs), the abundant lipid virulence factors in the cell wall of Myco…
View article: Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of <b><i>Mycobacterium tuberculosis</i></b>
Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of <b><i>Mycobacterium tuberculosis</i></b> Open
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycolic acids (MAs; alpha-, keto-, and methoxy-) and sugars (trehalose, glucose, and arabinose). Studies using mutant Mtb strains have sh…
View article: Preparation of the tri-arabino di-mycolate fragment of mycobacterial arabinogalactan from defined synthetic mycolic acids
Preparation of the tri-arabino di-mycolate fragment of mycobacterial arabinogalactan from defined synthetic mycolic acids Open
View article: <i>Mycobacterium tuberculosis</i>‐associated synthetic mycolates differentially exert immune stimulatory adjuvant activity
<i>Mycobacterium tuberculosis</i>‐associated synthetic mycolates differentially exert immune stimulatory adjuvant activity Open
Mycolic acids (MAs) are highly hydrophobic long‐chain α‐alkyl β‐hydroxy fatty acids present in the cell wall of Mycobacterium tuberculosis ( Mtb ) as a complex mixture of molecules with a common general structure but with variable function…