Maurice B. Hallett
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View article: Multimodal neuroimaging of fatigability development
Multimodal neuroimaging of fatigability development Open
Fatigability refers to the inability of the neuromuscular system to generate enough force to produce movements to meet task challenges. Fatigability has a central and a peripheral component linked via the neuromuscular system, but how thes…
View article: Intraphagosomal Free Ca2+ Changes during Phagocytosis
Intraphagosomal Free Ca2+ Changes during Phagocytosis Open
Phagocytosis (and endocytosis) is an unusual cellular process that results in the formation of a novel subcellular organelle, the phagosome. This phagosome contains not only the internalised target of phagocytosis but also the external med…
View article: Intraphagosomal Free Ca2+Changes during Phagocytosis
Intraphagosomal Free Ca2+Changes during Phagocytosis Open
Phagocytosis (and endocytosis) is an unusual cellular process which results in the formation of a novel subcellular organelle, the phagosome. This phagosome contains not only the internalised target of phagocytosis, but also the external m…
View article: Localisation of Intracellular Signals and Responses during Phagocytosis
Localisation of Intracellular Signals and Responses during Phagocytosis Open
Phagocytosis is one of the most polarised of all cellular activities. Both the stimulus (the target for phagocytosis) and the response (its internalisation) are focussed at just one part of the cell. At the locus, and this locus alone, pse…
View article: Ca2+-activated cleavage of ezrin visualised dynamically in living myeloid cells during cell surface area expansion
Ca2+-activated cleavage of ezrin visualised dynamically in living myeloid cells during cell surface area expansion Open
The intracellular events underlying phagocytosis, a crucial event for innate immunity, are still unresolved. In order to test whether the reservoir of membrane required for the formation of the phagocytic pseudopodia is maintained by corti…
View article: The newspaper man: Michael Andrews and the art of painted collage
The newspaper man: Michael Andrews and the art of painted collage Open
This article focuses on an ambitious and complex pair of pictures painted by the prominent English artist Michael Andrews in the early 1960s, in which he juxtaposes a mass of visual elements taken from various photographic sources. Deer Pa…
View article: Neutrophil Cell Shape Change: Mechanism and Signalling during Cell Spreading and Phagocytosis
Neutrophil Cell Shape Change: Mechanism and Signalling during Cell Spreading and Phagocytosis Open
Perhaps the most important feature of neutrophils is their ability to rapidly change shape. In the bloodstream, the neutrophils circulate as almost spherical cells, with the ability to deform in order to pass along narrower capillaries. Up…
View article: John Singleton Copley and the World of Prints
John Singleton Copley and the World of Prints Open
John Singleton Copley (1738–1815) is known for his painted portraits of colonial Americans (oils, pastels, and miniatures) and his English history pictures, but the relationship between Copley and prints is relatively obscure. Yet he was i…
View article: Conformationally restricted calpain inhibitors
Conformationally restricted calpain inhibitors Open
Oxidised α-mercaptoacrylic acid derivatives are potent conformationally restricted calpain-I inhibitors that mimic the endogenous inhibitor calpastatin.