Mark Bitsch Vestergaard
YOU?
Author Swipe
View article: Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply
Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply Open
Gastrointestinal hormones are essential for nutrient handling and regulation of glucose metabolism and may affect postprandial blood redistribution. In a randomized cross-over design in 10 healthy men, the involvement of glucose-dependent …
View article: Cognitive aging and reserve factors in the Metropolit 1953 Danish male cohort
Cognitive aging and reserve factors in the Metropolit 1953 Danish male cohort Open
Identifying early predictors of cognitive decline and at-risk individuals is essential for timely intervention and prevention of dementia. This study aimed to detect neurobiological changes and factors related to cognitive performance in t…
View article: The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation Open
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, the exact mechanisms are not known. A po…
View article: Age-related decline in cerebral oxygen consumption in multiple sclerosis
Age-related decline in cerebral oxygen consumption in multiple sclerosis Open
Cerebral oxygen metabolism is altered in relapsing-remitting multiple sclerosis (RRMS), possibly a result of disease related cerebral atrophy with subsequent decreased oxygen demand. However, MS inflammation can also inhibit brain metaboli…
View article: Patients with type 1 diabetes and albuminuria have a reduced brain glycolytic capability that is correlated with brain atrophy
Patients with type 1 diabetes and albuminuria have a reduced brain glycolytic capability that is correlated with brain atrophy Open
Introduction Patients with type 1 diabetes (T1D) demonstrate brain alterations, including white matter lesions and cerebral atrophy. In this case–control study, we investigated if a reason for this atrophy could be because of diabetes-rela…
View article: Reproducibility of cerebral blood flow, oxygen metabolism, and lactate and N-acetyl-aspartate concentrations measured using magnetic resonance imaging and spectroscopy
Reproducibility of cerebral blood flow, oxygen metabolism, and lactate and N-acetyl-aspartate concentrations measured using magnetic resonance imaging and spectroscopy Open
In humans, resting cerebral perfusion, oxygen consumption and energy metabolism demonstrate large intersubject variation regardless of methodology. Whether a similar large variation is also present longitudinally in individual subjects is …
View article: Single-Voxel MR Spectroscopy of Gliomas with s-LASER at 7T
Single-Voxel MR Spectroscopy of Gliomas with s-LASER at 7T Open
Background and Purpose: Magnetic resonance spectroscopy (MRS)—a method of analysing metabolites in vivo—has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field strengths, MRS provides a…
View article: GLP−1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading
GLP−1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading Open
Background GLP‐1 (glucagon‐like peptide‐1) receptor agonists exert beneficial long‐term effects on cardiovascular and renal outcomes. In humans, the natriuretic effect of GLP‐1 depends on GLP‐1 receptor interaction, is accompanied by suppr…
View article: Capillary transit time heterogeneity inhibits cerebral oxygen metabolism in patients with reduced cerebrovascular reserve capacity from steno-occlusive disease
Capillary transit time heterogeneity inhibits cerebral oxygen metabolism in patients with reduced cerebrovascular reserve capacity from steno-occlusive disease Open
The healthy cerebral perfusion demonstrates a homogenous distribution of capillary transit times. A disruption of this homogeneity may inhibit the extraction of oxygen. A high degree of capillary transit time heterogeneity (CTH) describes …
View article: Single-voxel MR spectroscopy of gliomas with s-LASER at 7T
Single-voxel MR spectroscopy of gliomas with s-LASER at 7T Open
Background and Purpose: Magnetic resonance spectroscopy (MRS) – a method to analyse metabolites in vivo – has been utilized in several studies of brain glioma biomarkers at lower fields strengths. At ultrahigh field strengths, MRS provides…
View article: New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary Open
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the ori…
View article: Reproducibility and Optimal Arterial Input Function Selection in Dynamic Contrast‐Enhanced Perfusion <scp>MRI</scp> in the Healthy Brain
Reproducibility and Optimal Arterial Input Function Selection in Dynamic Contrast‐Enhanced Perfusion <span>MRI</span> in the Healthy Brain Open
Background Dynamic contrast‐enhanced MRI (DCE‐MRI) has seen increasing use for quantification of low level of blood–brain barrier (BBB) leakage in various pathological disease states and correlations with clinical outcomes. However, curren…
View article: Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis—A Systematic Review
Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis—A Systematic Review Open
The inflammatory processes observed in the central nervous system in multiple sclerosis (MS) could damage the endothelium of the cerebral vessels and lead to a dysfunctional regulation of vessel tonus and recruitment, potentially impairing…
View article: Blood-brain barrier permeability changes in the first year after alemtuzumab treatment predict 2-year outcomes in relapsing-remitting multiple sclerosis
Blood-brain barrier permeability changes in the first year after alemtuzumab treatment predict 2-year outcomes in relapsing-remitting multiple sclerosis Open
BBB permeability predicted alemtuzumab efficacy at two years, indicating that BBB permeability is a biomarker of treatment response in RRMS.
View article: Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure
Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure Open
Exposure to moderate hypoxia in humans leads to cerebral lactate production, which occurs even when the cerebral metabolic rate of oxygen (CMRO2) is unaffected. We searched for the mechanism of this lactate production by testing the hypoth…
View article: PET imaging of meningioma with 18F-FLT: a predictor of tumour progression
PET imaging of meningioma with 18F-FLT: a predictor of tumour progression Open
We have previously reported that PET with 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) provides a non-invasive assessment of cell proliferation in vivo in meningiomas. The purpose of this prospective study was to evaluate the potential of 18F…
View article: MNGI-08. PHARMACOKINETIC ANALYSIS OF 68GA-DOTATOC IN MENINGIOMAS USING PET/CT FOR ASSESSMENT OF SOMATOSTATIN RECEPTORS AND CORRELATION WITH ANGIOGENESIS, INFLAMMATION AND PROLIFERATION
MNGI-08. PHARMACOKINETIC ANALYSIS OF 68GA-DOTATOC IN MENINGIOMAS USING PET/CT FOR ASSESSMENT OF SOMATOSTATIN RECEPTORS AND CORRELATION WITH ANGIOGENESIS, INFLAMMATION AND PROLIFERATION Open
BACKGROUND A quantitative correlative analysis between 68Ga-DOTATOC accumulation using PET/CT and somatostatin receptor subtype 2 (SSTR2) in meningiomas was conducted. The possible contributions of angiogenesis and inflammation were invest…
View article: MNGI-13. DYNAMIC IMAGING OF MENINGIOMA WITH 3’-DEOXY-3’-[18F]-FLUOROTHYMIDINE USING POSITRON EMISSION TOMOGRAPHY: A POSSIBLE PREDICTOR OF TUMOR GROWTH
MNGI-13. DYNAMIC IMAGING OF MENINGIOMA WITH 3’-DEOXY-3’-[18F]-FLUOROTHYMIDINE USING POSITRON EMISSION TOMOGRAPHY: A POSSIBLE PREDICTOR OF TUMOR GROWTH Open
BACKGROUND Positron emission tomography (PET) with 3’-deoxy-3’-[18F]-fluorothymidine (18F-FLT) provides a non-invasive assessment of in vivo tumor proliferation that could be useful for predicting growth potential in meningiomas. We aimed …
View article: Comparison of simultaneous arterial spin labeling MRI and <sup>15</sup>O-H<sub>2</sub>O PET measurements of regional cerebral blood flow in rest and altered perfusion states
Comparison of simultaneous arterial spin labeling MRI and <sup>15</sup>O-H<sub>2</sub>O PET measurements of regional cerebral blood flow in rest and altered perfusion states Open
Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique that may provide fully quantitative regional cerebral blood flow (rCBF) images. However, before its application in clinical routine, ASL needs to be…
View article: Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain
Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain Open
The aging brain is associated with atrophy along with functional and metabolic changes. In this study, we examined age-related changes in resting brain functions and the vulnerability of brain physiology to hypoxic exposure in humans in vi…
View article: Phase contrast mapping MRI measurements of global cerebral blood flow across different perfusion states – A direct comparison with <sup>15</sup>O-H<sub>2</sub>O positron emission tomography using a hybrid PET/MR system
Phase contrast mapping MRI measurements of global cerebral blood flow across different perfusion states – A direct comparison with <sup>15</sup>O-H<sub>2</sub>O positron emission tomography using a hybrid PET/MR system Open
Phase-contrast mapping (PCM) magnetic resonance imaging (MRI) provides easy-access non-invasive quantification of global cerebral blood flow (gCBF) but its accuracy in altered perfusion states is not established. We aimed to compare paired…
Components of day-to-day variability of cerebral perfusion measurements – Analysis of phase contrast mapping magnetic resonance imaging measurements in healthy volunteers Open
Our results suggest that short-term day-to-day variability of gCBF is relatively low compared to between-subject variability when studied in standardized conditions, whereas long-term variability in an aged population appears to be much la…
View article: No evidence for direct effects of recombinant human erythropoietin on cerebral blood flow and metabolism in healthy humans
No evidence for direct effects of recombinant human erythropoietin on cerebral blood flow and metabolism in healthy humans Open
Erythropoietin (EPO) is expressed in human brain tissue, but its exact role is unknown. EPO may improve the efficiency of oxidative metabolism and has neuroprotective properties against hypoxic injuries in animal models. We aimed to invest…
View article: Cerebral metabolism and vascular reactivity during breath-hold and hypoxic challenge in freedivers and healthy controls
Cerebral metabolism and vascular reactivity during breath-hold and hypoxic challenge in freedivers and healthy controls Open
The goal of the present study was to examine the cerebral metabolism and vascular reactivity during extended breath-holds (ranging from 2 min 32 s to 7 min 0 s) and during a hypoxic challenge in freedivers and non-diver controls. Magnetic …