Explanipedia

SG09 An epidemiological study of ichthyoses in England from 1998 to 2024 Open

M. Eisner, Mark Blyth, Jennifer M. Broughan, Maria Kwiatkowska, Lizz Paley , et al. · 2025

The ichthyoses are a heterogeneous group of genodermatoses resulting in disordered skin cornification. Patients living with ichthyosis may have severe phenotypes leading to significant morbidity and mortality. There is currently no registe…

SG10 (P058) The epidemiology of epidermolysis bullosa in England, 1997–2024: a retrospective national cohort study Open

Maria Kwiatkowska, Sagair Hussain, Tony Byrne, Carly Fields, Celia Moss , et al. · 2025

Epidermolysis bullosa (EB) comprises a group of rare genetic blistering disorders with variable severity. Epidemiological studies on EB have previously often relied on data from specialist centres. However, many patients are managed outsid…

P058 The epidemiology of epidermolysis bullosa in England, 1997–2024: a retrospective national cohort study Open

Maria Kwiatkowska, Sagair Hussain, Tony Byrne, Carly Fields, Celia Moss , et al. · 2025

Epidermolysis bullosa (EB) comprises a group of rare genetic blistering disorders with variable severity. Epidemiological studies on EB have previously often relied on data from specialist centres. However, many patients are managed outsid…

413 Robotic Arm-Assisted Bi-Unicompartmental Arthroplasty (RoBi-UKA) Versus Total Knee Arthroplasty (TKR) Using Objective Measures of Physical Activity: A Prospective, Randomised Controlled Trial (RCT) Open

Sreeraag Kanakala, M Brkljac, Matthew Banger, James Doonan, Philip Rowe , et al. · 2025

Introduction RoBi-UKA is a bone-conserving, cruciate-sparing alternative to TKA. Patient-reported outcome measures (PROMs) do not differentiate the procedures, and conflicting data exists on physiological gait preservation. Physical activi…

Prospective, randomised controlled trial comparing robotic arm‐assisted bi‐unicompartmental knee arthroplasty to total knee arthroplasty Open

Omer M. Farhan‐Alanie, James Doonan, Philip Rowe, Matthew Banger, Bryn Jones , et al. · 2025

Purpose The objective of this study was to compare the clinical outcomes 2 years following surgery between robotic‐arm assisted bi‐unicompartmental knee arthroplasty (bi‐UKA) compared with conventional mechanically aligned total knee arthr…

Implementation of a national rapid prenatal exome sequencing service in England: evaluation of service outcomes and factors associated with regional variation Open

Rema Ramakrishnan, Corinne Mallinson, Steven Hardy, Jennifer M. Broughan, Mark Blyth , et al. · 2024

Introduction Prenatal exome sequencing (pES) can enhance genetic diagnosis of fetuses with structural anomalies and has recently been introduced as a national service in England. We aimed to examine service outcomes such as diagnostic yiel…

Validity of wearable sensors for total knee arthroplasty (TKA) rehabilitation: A study in younger and older healthy participants Open

Lauren Forsyth, Alexandra Ligeti, Mark Blyth, Jon Clarke, Philip Riches · 2024

MotionSense^TM was found to accurately estimate knee flexion angles during several common activities compared to Vicon motion capture.

Validity of Wearable Sensors for Total Knee Arthroplasty (Tka) Rehabilitation: A Study in Younger and Older Healthy Participants Open

Lauren Forsyth, Alexandra Ligeti, Mark Blyth, Jon Clarke, Philip Riches · 2024

The effect of acute and chronic inflammatory response on plasma and erythrocyte selenium concentrations: Implications for assessing selenium nutritional status Open

Anthony Catchpole, Donogh Maguire, John Wadsworth, Donald C. McMillan, Owen Sheerins , et al. · 2023

Summary: Background: Selenium is an essential trace element and its deficiency can lead to dysfunction in multiple areas. Selenium status is commonly assessed by its measurement in plasma but this may be an unreliable marker in patients wi…

Cost-utility analysis of robotic arm-assisted medial compartment knee arthroplasty Open

Nick D. Clement, Ewen Fraser, Alisdair Gilmour, James Doonan, Angus MacLean , et al. · 2023

Aims To perform an incremental cost-utility analysis and assess the impact of differential costs and case volume on the cost-effectiveness of robotic arm-assisted unicompartmental knee arthroplasty (rUKA) compared to manual (mUKA). Methods…

Deficits in muscle strength are not seen following recovery from augmented primary repair of anterior cruciate ligament tears Open

William Wilson, Matthew Banger, Graeme P. Hopper, Mark Blyth, Gordon M. Mackay , et al. · 2023

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747 Ten Year Outcomes After Surgical Fixation of Tibial Plateau Fractures Open

Ata Khalid, Christine Nelson, Matthew Howell, Onyedikachi Eseonu, James Doonan , et al. · 2023

Aim This study represents one of the largest clinical case series' evaluating long-term outcomes following surgical fixation of tibial plateau fractures over a 10-year follow-up. The primary aim is to evaluate the incidence of TKR and risk…

Robotic Arthroplasty Clinical and cost Effectiveness Randomised controlled trial (RACER-knee): a study protocol Open

James M. Griffin, Edward T. Davis, Helen Parsons, Elke Gemperlé Mannion, Chetan Khatri , et al. · 2023

Introduction Robotic-assisted knee replacement systems have been introduced to healthcare services worldwide in an effort to improve clinical outcomes for people, although high-quality evidence that they are clinically, or cost-effective r…

Predicted waiting times for orthopaedic surgery Open

Luke Farrow, Paul J. Jenkins, E. Dunstan, Alastair W. Murray, Mark Blyth , et al. · 2022

Cite this article: Bone Joint Res 2022;11(12):890–892.

No advantage with navigated versus conventional mechanically aligned total knee arthroplasty—10 year results of a randomised controlled trial Open

Omer M. Farhan‐Alanie, Tareq Altell, Sinéad M O'Donnell, P. May, James Doonan , et al. · 2022

Purpose Computer‐assisted surgery (CAS) total knee arthroplasty (TKA) remains a controversial area of surgical practice. The aim of this study is to report the ten‐year revision rates and patient‐reported outcome measures (PROMS) of a sing…

Robotic arm-assisted versus manual unicompartmental knee arthroplasty Open

Junren Zhang, Nathan Ng, Chloe E. H. Scott, Mark Blyth, Fares S. Haddad , et al. · 2022

Aims This systematic review aims to compare the precision of component positioning, patient-reported outcome measures (PROMs), complications, survivorship, cost-effectiveness, and learning curves of MAKO robotic arm-assisted unicompartment…

Anterior cruciate ligament repair with internal brace augmentation: A systematic review Open

William Wilson, Graeme P. Hopper, Matthew Banger, Mark Blyth, Philip Riches , et al. · 2022

This systematic review with meta-analysis shows that ACL repair with internal bracing is a safe technique for treatment of proximal ruptures, with a failure rate of 10.4%. Subjective scores and clinical laxity testing also revealed satisfa…

Meniscal Preservation is More Likely When Performed with Acute Anterior Cruciate Ligament Repair Rather Than with Anterior Cruciate Ligament Reconstruction Open

William Wilson, Graeme P. Hopper, Chris Hamilton, Lucas O’Donnell, Mark Blyth , et al. · 2022

BackgroundRupture of the anterior cruciate ligament (ACL) often occurs in conjunction with meniscal tears. In this study we investigate the rates and outcomes of meniscal repair surgery performed with ACL reconstruction compared with acute…

Quantifying graft impingement in anterior cruciate ligament reconstruction Open

William Wilson, Graeme P. Hopper, M. O'Boyle, L Henderson, Mark Blyth · 2022

The amount of impingement did not correlate with tunnel position, which was located within the recommended area. There was a weak negative correlation between NWI and lateral impingement (r_s = -0.16, p = 0.01), and NDI and anter…

Comparable rates of secondary surgery between anterior cruciate ligament repair with suture tape augmentation and anterior cruciate ligament reconstruction Open

Graeme P. Hopper, William Wilson, L. O’Donnell, Chris Hamilton, Mark Blyth , et al. · 2022

Purpose The aim of this study was to determine the frequency of secondary surgery following anterior cruciate ligament (ACL) repair with suture tape augmentation in comparison to conventional hamstring ACL reconstruction. We hypothesised t…

Early outcomes after robotic arm-assisted bi-unicompartmental knee arthroplasty compared with total knee arthroplasty: a prospective, randomized controlled trial Open

Mark Blyth, Matthew Banger, James Doonan, Bryn Jones, Angus MacLean , et al. · 2021

Aims The aim of this study was to compare the clinical outcomes of robotic arm-assisted bi-unicompartmental knee arthroplasty (bi-UKA) with conventional mechanically aligned total knee arthroplasty (TKA) during the first six weeks and at o…

Significant differences in rates of aseptic loosening between two variations of a popular total knee arthroplasty design Open

Michael J. Brown, Rohan Ramasubbu, Mark Jenkinson, James Doonan, Mark Blyth , et al. · 2021

Purpose The NexGen Legacy Posterior Stabilised (LPS) prosthesis (Zimmer Biomet, Warsaw, IN, USA) has augmentable and non-augmentable tibial baseplate options. We have noted an anecdotal increase in the number of cases requiring early revis…

Robotic arm-assisted versus conventional medial unicompartmental knee arthroplasty: five-year clinical outcomes of a randomized controlled trial Open

Matthew Banger, James Doonan, Philip Rowe, Bryn Jones, Angus MacLean , et al. · 2021

Aims Unicompartmental knee arthroplasty (UKA) is a bone-preserving treatment option for osteoarthritis localized to a single compartment in the knee. The success of the procedure is sensitive to patient selection and alignment errors. Robo…

The relation between acute changes in the systemic inflammatory response and circulating thiamine and magnesium concentrations after elective knee arthroplasty Open

Donogh Maguire, Anthony Catchpole, Owen Sheerins, Dinesh Talwar, Alana Burns , et al. · 2021

Thiamine diphosphate (TDP) and magnesium are co-factors for key enzymes in human intermediary metabolism. However, their role in the systemic inflammatory response (SIR) is not clear. Therefore, the aim of the present study was to examine …

The accuracy of femoral component rotational measurements using computed tomography—a cadaveric study Open

Onyedikachi Eseonu, Calum Cree, Martin Sambrook, Mark Blyth, Bryn Jones · 2020

Robotic arm-assisted bi-unicompartmental knee arthroplasty maintains natural knee joint anatomy compared with total knee arthroplasty: a prospective randomized controlled trial Open

Matthew Banger, William D. Johnston, Nima Razii, James Doonan, Philip Rowe , et al. · 2020

Aims The aim of this study was to compare robotic arm-assisted bi-unicompartmental knee arthroplasty (bi-UKA) with conventional mechanically aligned total knee arthroplasty (TKA) in order to determine the changes in the anatomy of the knee…

Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study Open

Lothar Seefried, Mark Blyth, Rohit Maheshwari, Stephen McDonnell, Guillaume Frappin , et al. · 2020

Background: Topical diclofenac, a nonsteroidal anti-inflammatory drug, has proven efficacy and safety in the management of osteoarthritis pain. We investigated penetration of topical diclofenac into knee synovial tissue and fluid (primary …

Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data Open

Stuart Aitken, Helen V. Firth, Jeremy F. McRae, Mihail Halachev, Usha Kini , et al. · 2019

Tranexamic acid toxicity in human periarticular tissues Open

Michael McLean, Karen McCall, I.D.M. Smith, Mark Blyth, Susan Kitson , et al. · 2019

Objectives Tranexamic acid (TXA) is an anti-fibrinolytic medication commonly used to reduce perioperative bleeding. Increasingly, topical administration as an intra-articular injection or perioperative wash is being administered during sur…

5-year gait analysis as a secondary outcome of a fixed bearing robotic assisted versus mobile bearing manual UKA RCT Open

Matthew Banger, Philip Rowe, Lindsay Millar, Mark Blyth, Angus MacLean , et al. · 2018

Total knee arthroplasty (TKA) procedures have recognised differences in knee kinematics and kinetics from healthy knees. This study reports on the less documented knee kinematics and kinetics of uni-compartmental knee arthroplasty (UKA) pa…

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