Mark Burroughs
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View article: Trained ILCs confer adaptive immunity-independent protection against influenza
Trained ILCs confer adaptive immunity-independent protection against influenza Open
Seasonal influenza causes 290,000–650,000 deaths annually, with vaccination efficacy ranging from 10 to 60%. The emergence of drug-resistant and highly pathogenic avian influenza viruses underscores the urgent need for novel protective str…
View article: A comparison of genomic methods to assess DNA replication timing
A comparison of genomic methods to assess DNA replication timing Open
Replication timing (RT), the temporal order in which genomic regions replicate, is considered a functional feature of multiple cellular processes and chromatin organization. Two approaches to measure RT are the Repli-seq and DNA copy numbe…
View article: Short-Read and Long-Read Whole Genome Sequencing for SARS-CoV-2 Variants Identification
Short-Read and Long-Read Whole Genome Sequencing for SARS-CoV-2 Variants Identification Open
Genomic surveillance of SARS-CoV-2 is crucial for detecting emerging variants and informing public health responses. Various sequencing technologies are used for whole genome sequencing of SARS-CoV-2. This cross-platform benchmark study ap…
View article: Sentinel Surveillance reveals phylogenetic diversity and detection of linear plasmids harboring <i>vanA</i> and <i>optrA</i> among enterococci collected in the United States
Sentinel Surveillance reveals phylogenetic diversity and detection of linear plasmids harboring <i>vanA</i> and <i>optrA</i> among enterococci collected in the United States Open
Enterococcus faecalis and Enterococcus faecium are frequent causes of healthcare-associated infections. Antimicrobial-resistant enterococci pose a serious public health threat, particularly vancomycin-resistant enterococci (VRE), for which…
View article: Complete genome sequences of four representative <i>Corynebacterium belfantii</i> strains
Complete genome sequences of four representative <i>Corynebacterium belfantii</i> strains Open
This report describes the complete genome sequence assemblies from four representative isolates of the human pathogen Corynebacterium belfantii . These data provide necessary references to aid accurate sequence-based species discrimination…
View article: The frequency and function of nucleoprotein-specific CD8 <sup>+</sup> T cells are critical for heterosubtypic immunity against influenza virus infection
The frequency and function of nucleoprotein-specific CD8 <sup>+</sup> T cells are critical for heterosubtypic immunity against influenza virus infection Open
Cytotoxic T lymphocytes (CTLs) mediate host defense against viral and intracellular bacterial infections and tumors. However, the magnitude of CTL response and their function needed to confer heterosubtypic immunity against influenza virus…
View article: Use of Fluorescence Guidance in Bariatric Surgery
Use of Fluorescence Guidance in Bariatric Surgery Open
Fluorescence guidance with indocyanine green (ICG) is utilized during primary and revisional bariatric surgery. ICG is uniquely useful to the bariatric surgeon, as it can assess for perfusion when given intravenously and anastomotic contin…
View article: Genomic deletions and rearrangements in monkeypox virus from the 2022 outbreak, USA
Genomic deletions and rearrangements in monkeypox virus from the 2022 outbreak, USA Open
Genomic surveillance of monkeypox virus (MPXV) during the 2022 outbreak has been mainly focused on single nucleotide polymorphism (SNP) changes. DNA viruses, including MPXV, have a lower SNP mutation rate than RNA viruses due to higher fid…
View article: Assessment of Clinical and Virological Characteristics of SARS-CoV-2 Infection Among Children Aged 0 to 4 Years and Their Household Members
Assessment of Clinical and Virological Characteristics of SARS-CoV-2 Infection Among Children Aged 0 to 4 Years and Their Household Members Open
Importance Few studies have prospectively assessed SARS-CoV-2 community infection in children aged 0 to 4 years. Information about SARS-CoV-2 incidence and clinical and virological features in young children could help guide prevention and…
View article: Impact of Age and Symptom Development on SARS-CoV-2 Transmission in Households With Children—Maryland, New York, and Utah, August 2020–October 2021
Impact of Age and Symptom Development on SARS-CoV-2 Transmission in Households With Children—Maryland, New York, and Utah, August 2020–October 2021 Open
Background Households are common places for spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated factors associated with household transmission and acquisition of SARS-CoV-2. Methods Households with child…
View article: Selective Whole-Genome Amplification as a Tool to Enrich Specimens with Low Treponema pallidum Genomic DNA Copies for Whole-Genome Sequencing
Selective Whole-Genome Amplification as a Tool to Enrich Specimens with Low Treponema pallidum Genomic DNA Copies for Whole-Genome Sequencing Open
Syphilis is a sexually transmitted, disseminated acute and chronic infection caused by the bacterial pathogen Treponema pallidum subspecies pallidum . Primary syphilis typically presents as single or multiple mucocutaneous lesions and, if …
View article: Selective whole genome amplification as a tool to enrich specimens with low<i>Treponema pallidum</i>genomic DNA copies for whole genome sequencing
Selective whole genome amplification as a tool to enrich specimens with low<i>Treponema pallidum</i>genomic DNA copies for whole genome sequencing Open
Downstream next generation sequencing (NGS) of the syphilis spirochete Treponema pallidum subspecies pallidum ( T. pallidum ) is hindered by low bacterial loads and the overwhelming presence of background metagenomic DNA in clinical specim…
View article: Draft Chromosome Sequences of a Clinical Isolate of the Free-Living Ameba Naegleria fowleri
Draft Chromosome Sequences of a Clinical Isolate of the Free-Living Ameba Naegleria fowleri Open
We present the chromosome sequences of a Naegleria fowleri isolate from a human primary amebic meningoencephalitis (PAM) case. The genome sequences were assembled from Illumina HiSeq and PacBio sequencing data and verified with the optical…
View article: Adrenal Ganglioneuroma: A Rare Tumor of the Autonomic Nervous System
Adrenal Ganglioneuroma: A Rare Tumor of the Autonomic Nervous System Open
Ganglioneuromas (GNs) are benign, differentiated tumors that are derived from neural crest sympathogonia. They can be found anywhere in the body along autonomic ganglia. These tumors are seen most often in individuals over 10 years of age …
View article: Benefits and shortcomings of utilizing telemedicine during the COVID-19 pandemic
Benefits and shortcomings of utilizing telemedicine during the COVID-19 pandemic Open
As the COVID-19 pandemic overwhelmed health care systems around the world, new strategies to mitigate its spread and provide patients access to health care have been employed. Although a critical component of this strategy, telemedicine is…
View article: Division of the genus Chryseobacterium: Observation of discontinuities in amino acid identity values, a possible consequence of major extinction events, guides transfer of nine species to the genus Epilithonimonas, eleven species to the genus Kaistella, and three species to the genus Halpernia gen. nov., with description of Kaistella daneshvariae sp. nov. and Epilithonimonas vandammei sp. nov. derived from clinical specimens
Division of the genus Chryseobacterium: Observation of discontinuities in amino acid identity values, a possible consequence of major extinction events, guides transfer of nine species to the genus Epilithonimonas, eleven species to the genus Kaistella, and three species to the genus Halpernia gen. nov., with description of Kaistella daneshvariae sp. nov. and Epilithonimonas vandammei sp. nov. derived from clinical specimens Open
The genus Chryseobacterium in the family Weeksellaceae is known to be polyphyletic. Amino acid identity (AAI) values were calculated from whole-genome sequences of species of the genus Chryseobacterium, and their distribution was found to …
View article: Conserved Patterns of Symmetric Inversion in the Genome Evolution of <i>Bordetella</i> Respiratory Pathogens
Conserved Patterns of Symmetric Inversion in the Genome Evolution of <i>Bordetella</i> Respiratory Pathogens Open
Bordetella pertussis is the primary agent of whooping cough (pertussis). The Bordetella genus includes additional pathogens of animals and humans, including some that cause pertussis-like respiratory illness. The chromosome of B. pertussis…
View article: Improving health self-efficacy at a community health fair in Lubbock, Texas
Improving health self-efficacy at a community health fair in Lubbock, Texas Open
To improve the health self-efficacy of the Lubbock, Texas community, Texas Tech University Health Sciences Center School of Medicine students organized a health fair to promote patient education and improve awareness of health issues, such…
View article: Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis
Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis Open
Despite high vaccine coverage, pertussis cases in the United States have increased over the last decade. Growing evidence suggests that disease resurgence results, in part, from genetic divergence of circulating strain populations away fro…
View article: The History of Bordetella pertussis Genome Evolution Includes Structural Rearrangement
The History of Bordetella pertussis Genome Evolution Includes Structural Rearrangement Open
Despite high pertussis vaccine coverage, reported cases of whooping cough (pertussis) have increased over the last decade in the United States and other developed countries. Although Bordetella pertussis is well known for its limited gene …
View article: Complete Genome Sequences of Bordetella pertussis Vaccine Reference Strains 134 and 10536
Complete Genome Sequences of Bordetella pertussis Vaccine Reference Strains 134 and 10536 Open
Vaccine formulations and vaccination programs against whooping cough (pertussis) vary worldwide. Here, we report the complete genome sequences of two divergent Bordetella pertussis reference strains used in the production of pertussis vacc…
View article: CCDC 1022981: Experimental Crystal Structure Determination
CCDC 1022981: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1419240: Experimental Crystal Structure Determination
CCDC 1419240: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1419245: Experimental Crystal Structure Determination
CCDC 1419245: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1419246: Experimental Crystal Structure Determination
CCDC 1419246: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1419242: Experimental Crystal Structure Determination
CCDC 1419242: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1419243: Experimental Crystal Structure Determination
CCDC 1419243: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …