Mark C. Fernandez
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View article: CT135 mediates the resistance of Chlamydia trachomatis to primate interferon gamma stimulated immune defenses
CT135 mediates the resistance of Chlamydia trachomatis to primate interferon gamma stimulated immune defenses Open
Evading host innate immune defenses is a critical feature of Chlamydia trachomatis infections, and the mechanisms used by C. trachomatis to subvert these pathways are incompletely understood. We screened a library of chimeric…
View article: Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum
Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum Open
Syphilis continues to be a significant public health concern worldwide. The disease is endemic in many low- and middle-income countries, and rates have risen sharply in high-income countries over the last decade. The continued prevalence o…
View article: B-Cell Epitope Mapping of TprC and TprD Variants of Treponema pallidum Subspecies Informs Vaccine Development for Human Treponematoses
B-Cell Epitope Mapping of TprC and TprD Variants of Treponema pallidum Subspecies Informs Vaccine Development for Human Treponematoses Open
Several recent studies have focused on the identification, functional analysis, and structural characterization of outer membrane proteins (OMPs) of Treponema pallidum ( Tp ). The Tp species encompasses the highly related pallidum , perten…
View article: B-cell epitope mapping of TprC and TprD variants of<i>Treponema pallidum</i>subspecies
B-cell epitope mapping of TprC and TprD variants of<i>Treponema pallidum</i>subspecies Open
Several recent studies have focused on the identification, functional analysis, and structural characterization of outer membrane proteins (OMPs) of Treponema pallidum ( Tp ). The Tp species encompasses the highly related pallidum , perten…
View article: O01.6 A Chlamydia trachomatis inclusion membrane protein blocks interferon gamma stimulated immunity in humans and nonhuman primates
O01.6 A Chlamydia trachomatis inclusion membrane protein blocks interferon gamma stimulated immunity in humans and nonhuman primates Open
Background Epithelial cells that are stimulated with interferon gamma (IFNγ) carry out a potent immune response termed cell-autonomous immunity. While Chlamydia trachomatis is susceptible to murine cell-autonomous immunity, it evades this …
View article: Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum
Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum Open
Background An effective syphilis vaccine should elicit antibodies to Treponema pallidum subsp. pallidum ( T . p . pallidum ) surface antigens to induce pathogen clearance through opsonophagocytosis. Although the combination of bioinformati…
View article: Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of<i>Treponema pallidum</i>
Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of<i>Treponema pallidum</i> Open
Background An effective syphilis vaccine should elicit antibodies to Treponema pallidum subsp. pallidum ( T. p. pallidum ) surface antigens to induce pathogen clearance through opsonophagocytosis. Although the combination of bioinformatics…
View article: P854 Interspecies chimeras: a tool to identify chlamydial virulence factors
P854 Interspecies chimeras: a tool to identify chlamydial virulence factors Open
Background Chlamydia trachomatis is an obligate intracellular bacterium and is the most common notifiable infection in the United States. It spends its entire developmental cycle in a membrane bound cytosolic vacuole termed the incl…
View article: Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains
Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains Open
Background High rates of 23S rDNA mutations implicated in macrolide resistance have been identified in Treponema pallidum samples from syphilis patients in many countries. Nonetheless, some clinicians have been reluctant to abandon azithro…