C. Mark Johnson
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View article: Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilising Effects on the Scaffold PR65
Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilising Effects on the Scaffold PR65 Open
Protein phosphatase 2A (PP2A), an important therapeutic target, comprises a scaffold subunit PR65 composed of 15 HEAT (Huntingtin/elongation/A-subunit/TOR1) repeats, a catalytic subunit, and one of many different regulatory subunits that e…
View article: Emergence of ATP‐ and GTP‐Binding Aptamers from Single RNA Sequences by Error‐Prone Replication and Selection**
Emergence of ATP‐ and GTP‐Binding Aptamers from Single RNA Sequences by Error‐Prone Replication and Selection** Open
The spontaneous emergence of function from diverse RNA sequence pools is widely considered an important transition in the origin of life. Here we show that diverse sequence pools are not a prerequisite for the emergence of function. Starti…
View article: Development and Validation of a Smart Architecture for Thyristor Valves
Development and Validation of a Smart Architecture for Thyristor Valves Open
A high voltage thyristor converter is realized by many valve sections, whose volume is approximately occupied for only the 10% by thyristors and for the 10% by the relevant gate drivers. The remaining 80% is taken by passive auxiliary circ…
View article: A molecular mechanism for membrane chaperoning by a late embryogenesis abundant protein
A molecular mechanism for membrane chaperoning by a late embryogenesis abundant protein Open
Summary Environmental stress can result in substantial damage to proteins, membranes, and genetic material, impacting organismal survival 1-3 . Stress tolerance can be conferred by intrinsically disordered proteins (IDPs) 4 that lack stabl…
View article: Reliability and Characterization of Nanosilver Joints Prepared by a Time-Reduced Sintering Process
Reliability and Characterization of Nanosilver Joints Prepared by a Time-Reduced Sintering Process Open
This study investigates the power cycling reliability of nanosilver sintered joints formed by a time-reduced sintering process, designed for use on a die bonder. A range of sintering parameters, reflecting different levels of manufacturabi…
View article: A GaN-HEMT Compact Model Including Dynamic RDSon Effect for Power Electronics Converters
A GaN-HEMT Compact Model Including Dynamic RDSon Effect for Power Electronics Converters Open
In order to model GaN-HEMT switching transients and determine power losses, a compact model including dynamic RDSon effect is proposed herein. The model includes mathematical equations to represent device static and capacitance-voltage cha…
View article: Emergence of function from single RNA sequences by Darwinian evolution
Emergence of function from single RNA sequences by Darwinian evolution Open
The spontaneous emergence of function from pools of random sequence RNA is widely considered an important transition in the origin of life. However, the plausibility of this hypothetical process and the number of productive evolutionary tr…
View article: Effect of structural stability on endolysosomal degradation and T‐cell reactivity of major shrimp allergen tropomyosin
Effect of structural stability on endolysosomal degradation and T‐cell reactivity of major shrimp allergen tropomyosin Open
Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross‐reactivity. Despite sequence similarities, their allergenicity varies greatly between ingested and inhaled inve…
View article: Multi‐frequency averaging (MFA) model of a generic electric vehicle powertrain suitable under variable frequency of averaging developed for remote operability
Multi‐frequency averaging (MFA) model of a generic electric vehicle powertrain suitable under variable frequency of averaging developed for remote operability Open
Geographically distributed hardware‐in‐the‐loop (HIL) testing has the potential to allow hybrid vehicle powertrain components (battery, motor drive, and engine) to be developed at geographically remote locations but tested concurrently and…
View article: Accurate Measurement of Dynamic on-State Resistances of GaN Devices Under Reverse and Forward Conduction in High Frequency Power Converter
Accurate Measurement of Dynamic on-State Resistances of GaN Devices Under Reverse and Forward Conduction in High Frequency Power Converter Open
Because of trapped charges in GaN transistor structure, device dynamic on-state resistance RDSon is increased when it is operated in high frequency switched power converters, in which device is possibly operated by zero voltage switching (…
View article: Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin
Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin Open
Background Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross-reactivity. Despite structural similarities, their allergenicity varies greatly between ingested and inhaled in…
View article: Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen‐presenting cells and promotes resistance to <i>Salmonella</i> infection
Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen‐presenting cells and promotes resistance to <i>Salmonella</i> infection Open
Summary Signalling lymphocyte activation molecule family member 9 (SLAMF9) is an orphan receptor of the CD2/SLAM family of leucocyte surface proteins. Examination of SLAMF9 expression and function indicates that SLAMF9 promotes inflammatio…
View article: 10-kV SiC MOSFET Power Module With Reduced Common-Mode Noise and Electric Field
10-kV SiC MOSFET Power Module With Reduced Common-Mode Noise and Electric Field Open
The advancement of silicon carbide (SiC) power devices with voltage ratings exceeding 10 kV is expected to revolutionize medium- and high-voltage systems. However, present power module packages are limiting the performance of these unique …
View article: Design and Experimental Validation of a Wire-Bond-Less 10-kV SiC MOSFET Power Module
Design and Experimental Validation of a Wire-Bond-Less 10-kV SiC MOSFET Power Module Open
Wide bandgap (WBG) power devices with voltage ratings exceeding 10 kV have the potential to revolutionize medium-and high-voltage systems due to their high-speed switching and lower ON-state losses. However, the present power module packag…
View article: Peer Review #1 of "13C values of glycolytic amino acids as indicators of carbohydrate utilization in carnivorous fish (v0.1)"
Peer Review #1 of "13C values of glycolytic amino acids as indicators of carbohydrate utilization in carnivorous fish (v0.1)" Open
Background.Stable isotope analysis of single amino acids (AA) is usually applied in food web studies for tracing origins of elements and establishing trophic positions of consumers, but the method is also showing promise for characterizing…
View article: A novel manufacturing technique for integrating magnetic components windings on power module substrates
A novel manufacturing technique for integrating magnetic components windings on power module substrates Open
In this paper a novel manufacturing technique is investigated with the aim of integrating magnetic components (e.g. inductors and transformer) on power module substrates together with the switching devices, to minimize overall dimensions a…
View article: Three‐dimensional damage morphologies of thermomechanically deformed sintered nanosilver die attachments for power electronics modules
Three‐dimensional damage morphologies of thermomechanically deformed sintered nanosilver die attachments for power electronics modules Open
Summary A time‐lapse study of thermomechanical fatigue damage has been undertaken using three‐dimensional X‐ray computer tomography. Morphologies were extracted from tomography data and integrated with data from microscopy modalities at di…
View article: Data for: Effects of season and interval of prescribed burns on pyrogenic carbon in ponderosa pine stands in Malheur National Forest
Data for: Effects of season and interval of prescribed burns on pyrogenic carbon in ponderosa pine stands in Malheur National Forest Open
Supporting Information for: "Effects of season and interval of prescribed burns on pyrogenic carbon in ponderosa pine stands in Malheur National Forest"
View article: qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes Open
Killer cell immunoglobulin-like receptors (KIRs) are a set of inhibitory and activating immune receptors, on natural killer (NK) and T cells, encoded by a polymorphic cluster of genes on chromosome 19. Their best-characterized ligands are …
View article: qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes
qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes Open
Killer cell immunoglobulin-like receptors (KIRs) are a set of inhibitory and activating immune receptors, on natural killer (NK) and T cells, encoded by a polymorphic cluster of genes on chromosome 19. Their best-characterized ligands are …
View article: Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2
Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2 Open
p53 is frequently mutated in human cancers. Its levels are tightly regulated by the E3 ubiquitin ligase MDM2. The complex between MDM2 and p53 is largely formed by the interaction between the N-terminal domain of MDM2 and the N-terminal tr…
View article: Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity
Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity Open
McrBC is one of the three modification-dependent restriction enzymes encoded by the Escherichia coli K12 chromosome. Amongst restriction enzymes, McrBC and its close homologues are unique in employing the AAA+ domain for GTP hydrolysis-dep…
View article: pH-Driven RNA Strand Separation under Prebiotically Plausible Conditions
pH-Driven RNA Strand Separation under Prebiotically Plausible Conditions Open
Replication of nucleic acids in the absence of genetically encoded enzymes represents a critical process for the emergence of cellular life. Repeated separation of complementary RNA strands is required to achieve multiple cycles of chemica…