Mark C. Turner
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View article: SAT-659 Liver and Skeletal Muscle Interorgan Crosstalk: The Effects of Electrical Pulse Stimulation as an Exercise Mimetic on Lipid Accumulation in a Human Hepatocytes Model of Hepatic Steatosis
SAT-659 Liver and Skeletal Muscle Interorgan Crosstalk: The Effects of Electrical Pulse Stimulation as an Exercise Mimetic on Lipid Accumulation in a Human Hepatocytes Model of Hepatic Steatosis Open
Disclosure: R. Brett: None. C.L. Doig: None. L. Hodson: None. D. Renshaw: None. M.C. Turner: None. Introduction: Exercise can reduce the risk of developing liver disease by improving hepatic metabolism, however, the cellular mechanisms whi…
View article: Adverse effects of high‐fat diet consumption on contractile mechanics of isolated mouse skeletal muscle are reduced when supplemented with resveratrol
Adverse effects of high‐fat diet consumption on contractile mechanics of isolated mouse skeletal muscle are reduced when supplemented with resveratrol Open
Increasing evidence indicates resveratrol (RES) supplementation evokes anti‐obesogenic responses that could mitigate obesity‐induced reductions in skeletal muscle (SkM) contractility. Contractile function is a key facet of SkM health that …
View article: Klotho, the Greek goddess controlling the fate of skeletal muscle satellite cells
Klotho, the Greek goddess controlling the fate of skeletal muscle satellite cells Open
In humans, skeletal muscle enables the ability to perform a wide variety of tasks for daily living that range from walking to communicating and breathing. However, like other tissues and organs, ageing or disease can lead to a decline in s…
View article: Associations between the gut microbiome and metabolic, inflammatory, and appetitive effects of sleeve gastrectomy
Associations between the gut microbiome and metabolic, inflammatory, and appetitive effects of sleeve gastrectomy Open
Summary The complex and multifactorial etiology of obesity creates challenges for its effective long‐term management. Increasingly, the gut microbiome is reported to play a key role in the maintenance of host health and wellbeing, with its…
View article: Development of a novel low-order model for atrial function and a study of atrial mechano-electric feedback
Development of a novel low-order model for atrial function and a study of atrial mechano-electric feedback Open
Numerical models of the cardiovascular system have largely focused on the function of the ventricles, with atrial function often neglected. Furthermore, the time-varying elastance method that prescribes the pressure-volume relationship rat…
View article: Serum concentration impacts myosin heavy chain expression but not cellular respiration in human LHCN‐M2 myoblasts undergoing differentiation
Serum concentration impacts myosin heavy chain expression but not cellular respiration in human LHCN‐M2 myoblasts undergoing differentiation Open
The human LHCN‐M2 myoblast cell line has the potential to be used to investigate skeletal muscle development and metabolism. Experiments were performed to determine how different concentrations of human serum affect myogenic differentiatio…
View article: Suppression of Anti-Inflammatory Mediators in Metabolic Disease May Be Driven by Overwhelming Pro-Inflammatory Drivers
Suppression of Anti-Inflammatory Mediators in Metabolic Disease May Be Driven by Overwhelming Pro-Inflammatory Drivers Open
Obesity is a multifactorial disease and is associated with an increased risk of developing metabolic syndrome and co-morbidities. Dysregulated expansion of the adipose tissue during obesity induces local tissue hypoxia, altered secretory p…
View article: Physiological and pathophysiological concentrations of fatty acids induce lipid droplet accumulation and impair functional performance of tissue engineered skeletal muscle
Physiological and pathophysiological concentrations of fatty acids induce lipid droplet accumulation and impair functional performance of tissue engineered skeletal muscle Open
Fatty acids (FA) exert physiological and pathophysiological effects leading to changes in skeletal muscle metabolism and function, however, in vitro models to investigate these changes are limited. These experiments sought to establish the…
View article: Characterising hyperinsulinemia-induced insulin resistance in human skeletal muscle cells
Characterising hyperinsulinemia-induced insulin resistance in human skeletal muscle cells Open
Hyperinsulinaemia potentially contributes to insulin resistance in metabolic tissues, such as skeletal muscle. The purpose of these experiments was to characterise glucose uptake, insulin signalling and relevant gene expression in primary …
View article: A 7‐day high‐fat, high‐calorie diet induces fibre‐specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle
A 7‐day high‐fat, high‐calorie diet induces fibre‐specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle Open
Key points We have recently shown that a high‐fat, high‐calorie (HFHC) diet decreases whole body glucose clearance without impairing skeletal muscle insulin signalling, in healthy lean individuals. These diets are also known to increase sk…
View article: High-Fat Overfeeding Impairs Peripheral Glucose Metabolism and Muscle Microvascular eNOS Ser1177 Phosphorylation
High-Fat Overfeeding Impairs Peripheral Glucose Metabolism and Muscle Microvascular eNOS Ser1177 Phosphorylation Open
Context The mechanisms responsible for dietary fat-induced insulin resistance of skeletal muscle and its microvasculature are only partially understood. Objective To determine the impact of high-fat overfeeding on postprandial glucose flux…
View article: Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles
Physical Structuring of Injectable Polymeric Systems to Controllably Deliver Nanosized Extracellular Vesicles Open
Extracellular vesicles (EVs) are emerging as a promising alternative approach to cell‐therapies. However, to realize the potential of these nanoparticles as new regenerative tools, healthcare materials that address the current limitations …
View article: Scalable 3D Printed Molds for Human Tissue Engineered Skeletal Muscle
Scalable 3D Printed Molds for Human Tissue Engineered Skeletal Muscle Open
Tissue engineered skeletal muscle allows investigation of the cellular and molecular mechanisms that regulate skeletal muscle pathology. The fabricated model must resemble characteristics of in vivo tissue and incorporate cost-effec…
View article: The combined effect of sprint interval training and postexercise blood flow restriction on critical power, capillary growth, and mitochondrial proteins in trained cyclists
The combined effect of sprint interval training and postexercise blood flow restriction on critical power, capillary growth, and mitochondrial proteins in trained cyclists Open
Sprint interval training (SIT) combined with postexercise blood flow restriction (BFR) is a novel method to increase maximal oxygen uptake (V̇o 2max ) in trained individuals and also provides a potent acute stimulus for angiogenesis and mit…
View article: PL-017 High-fat overfeeding increases intramuscular triglyceride content and perilipin protein expression in human skeletal muscle
PL-017 High-fat overfeeding increases intramuscular triglyceride content and perilipin protein expression in human skeletal muscle Open
Objective High-fat high-calorie diets can induce whole body insulin resistance (IR) whilst increasing stores of intramuscular triglyceride (IMTG) contained within lipid droplets (LD). Perilipin (PLIN) proteins assist in IMTG storage. Synap…
View article: Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease
Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease Open
View article: The effect of chronic high insulin exposure upon metabolic and myogenic markers in C2C12 skeletal muscle cells and myotubes
The effect of chronic high insulin exposure upon metabolic and myogenic markers in C2C12 skeletal muscle cells and myotubes Open
Skeletal muscle is an insulin sensitive tissue and accounts for approximately 80% of post‐prandial glucose disposal. This study describes the effects of insulin, delivered for 72 h, to skeletal muscle myoblasts during differentiation or to…
View article: The acute angiogenic signalling response to low‐load resistance exercise with blood flow restriction
The acute angiogenic signalling response to low‐load resistance exercise with blood flow restriction Open
This study investigated protein kinase activation and gene expression of angiogenic factors in response to low‐load resistance exercise with or without blood flow restriction (BFR). In a repeated measures cross‐over design, six males perfo…
View article: The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men
The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men Open
Hepatokines are liver-secreted proteins with potential to influence glucose regulation and other metabolic parameters. This study investigated differences in adiposity status on 5 novel hepatokines and characterised their response to acute…
View article: Satellite cell response to concurrent resistance exercise and high-intensity interval training in sedentary, overweight/obese, middle-aged individuals
Satellite cell response to concurrent resistance exercise and high-intensity interval training in sedentary, overweight/obese, middle-aged individuals Open
View article: Leucine elicits myotube hypertrophy and enhances maximal contractile force in tissue engineered skeletal muscle in vitro
Leucine elicits myotube hypertrophy and enhances maximal contractile force in tissue engineered skeletal muscle in vitro Open
The amino acid leucine is thought to be important for skeletal muscle growth by virtue of its ability to acutely activate mTORC1 and enhance muscle protein synthesis, yet little data exist regarding its impact on skeletal muscle size and i…
View article: Hypoxia Impairs Muscle Function and Reduces Myotube Size in Tissue Engineered Skeletal Muscle
Hypoxia Impairs Muscle Function and Reduces Myotube Size in Tissue Engineered Skeletal Muscle Open
Contemporary tissue engineered skeletal muscle models display a high degree of physiological accuracy compared with native tissue, and therefore may be excellent platforms to understand how various pathologies affect skeletal muscle. Chron…
View article: Cell culture models of insulin signalling and glucose uptake
Cell culture models of insulin signalling and glucose uptake Open
Insulin maintains glucose homeostasis through its binding of the insulin receptor and activation of the insulin signalling cascade in insulin sensitive tissues. Skeletal muscle is a major endocrine organ, and is responsible for the majorit…