Mark Cadena
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View article: Osteopontin Deficiency Ameliorates Prostatic Fibrosis and Inflammation
Osteopontin Deficiency Ameliorates Prostatic Fibrosis and Inflammation Open
Fibrogenic and inflammatory processes in the prostate are linked to the development of lower urinary tract symptoms (LUTS) in men. Our previous studies identified that osteopontin (OPN), a pro-fibrotic cytokine, is abundant in the prostate…
View article: Osteopontin deficiency leads to the resolution of prostatic fibrosis and inflammation
Osteopontin deficiency leads to the resolution of prostatic fibrosis and inflammation Open
Fibrogenic and inflammatory processes in the prostate are linked to the development of lower urinary tract symptoms (LUTS) in men. Our previous studies identified that osteopontin (OPN), a pro-fibrotic cytokine, is abundant in the prostate…
View article: A uropathogenic <i>E. coli</i> UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate
A uropathogenic <i>E. coli</i> UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate Open
Bacterial infection is one known etiology of prostatic inflammation. Prostatic inflammation is associated with prostatic collagen accumulation and both are linked to progressive lower urinary tract symptoms in men. We characterized a model…
View article: Urethral luminal epithelia are castration‐insensitive cells of the proximal prostate
Urethral luminal epithelia are castration‐insensitive cells of the proximal prostate Open
Background Castration‐insensitive epithelial progenitors capable of regenerating the prostate have been proposed to be concentrated in the proximal region based on facultative assays. Functional characterization of prostate epithelial popu…
View article: Urethral luminal epithelia are castration-insensitive progenitors of the proximal prostate
Urethral luminal epithelia are castration-insensitive progenitors of the proximal prostate Open
Castration-insensitive epithelial progenitors capable of regenerating the prostate are concentrated in the proximal region close to the urethra, but the identification of these cells has been limited to individual cell surface markers. Her…
View article: An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections
An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections Open
Though many methods can be used to identify cell types contained in complex tissues, most require cell disaggregation and destroy information about where cells reside in relation to their microenvironment. Here, we describe a polytomous ke…
View article: The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice
The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice Open
The α-subunit of the heterotrimeric Gz protein, Gαz, promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gαz protein would preserve functional β-cell …
View article: Synergy Between Gαz Deficiency and GLP-1 Analog Treatment in Preserving Functional β-Cell Mass in Experimental Diabetes
Synergy Between Gαz Deficiency and GLP-1 Analog Treatment in Preserving Functional β-Cell Mass in Experimental Diabetes Open
A defining characteristic of type 1 diabetes mellitus (T1DM) pathophysiology is pancreatic β-cell death and dysfunction, resulting in insufficient insulin secretion to properly control blood glucose levels. Treatments that promote β-cell r…