Mark Carrington
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View article: Author response: Insights from aquaporin structures into drug-resistant sleeping sickness
Author response: Insights from aquaporin structures into drug-resistant sleeping sickness Open
View article: Insights from aquaporin structures into drug-resistant sleeping sickness
Insights from aquaporin structures into drug-resistant sleeping sickness Open
Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentami…
View article: TrypTag: Genome-wide subcellular protein localisation in Trypanosoma brucei.
TrypTag: Genome-wide subcellular protein localisation in Trypanosoma brucei. Open
TrypTag genome-wide protein localisation project data. Widefield epifluorescence microscope images of protein subcellular localisation in the unicellular eukaryotic pathogen Trypanosoma brucei by endogenous tagging with mNeonGreen (mNG). T…
View article: Insights from aquaporin structures into drug-resistant sleeping sickness
Insights from aquaporin structures into drug-resistant sleeping sickness Open
Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentami…
View article: Insights from aquaporin structures into drug-resistant sleeping sickness
Insights from aquaporin structures into drug-resistant sleeping sickness Open
Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentami…
View article: Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei
Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei Open
Trypanosoma brucei, the causal agent of Human and Animal African trypanosomiasis proliferates in the extracellular milieu of mammals. It acquires host macromolecular nutrients, by receptor mediated endocytosis. The best characterised recep…
View article: Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei
Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei Open
Trypanosoma brucei, the causal agent of Human and Animal African trypanosomiasis proliferates in the extracellular milieu of mammals. It acquires host macromolecular nutrients, by receptor mediated endocytosis. The best characterised recep…
View article: An auxin-inducible degron system for trypanosomes
An auxin-inducible degron system for trypanosomes Open
The ability to specifically degrade one protein in a cell provides an immediate insight into any resulting phenotype and thus function that may be occluded by secondary effects using other techniques. The auxin inducible degron is a method…
View article: Insights from aquaporin structures into drug-resistant sleeping sickness
Insights from aquaporin structures into drug-resistant sleeping sickness Open
Trypanosoma brucei is the causal agent of African trypanosomiasis in humans and animals, the latter resulting in significant negative economic impacts in afflicted areas of the world. Resistance has arisen to the trypanocidal drugs pentami…
View article: Distinct modes of interaction within eIF4F-like complexes and susceptibility to the RocA inhibitor for the Trypanosoma brucei EIF4AI translation initiation factor
Distinct modes of interaction within eIF4F-like complexes and susceptibility to the RocA inhibitor for the Trypanosoma brucei EIF4AI translation initiation factor Open
Trypanosomatids are parasitic protozoa responsible for major human diseases which are characterized by unique gene expression mechanisms. mRNA translation in these parasites is associated with multiple eIF4F-like complexes, required for mR…
View article: Cell surface localisation of GPI-anchored receptors in <i>Trypanosoma brucei</i>
Cell surface localisation of GPI-anchored receptors in <i>Trypanosoma brucei</i> Open
Trypanosoma brucei , the causal agent of Human and Animal African trypanosomiasis proliferates in the extracellular milieu of mammals. It acquires host macromolecular nutrients, by receptor mediated endocytosis. The best characterised rece…
View article: Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway
Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway Open
The exon junction complex (EJC) is a key player in metazoan mRNA quality control and is placed upstream of the exon-exon junction after splicing. Its inner core is composed of Magoh, Y14, eIF4AIII and BTZ and the outer core of proteins inv…
View article: How are <i>Trypanosoma brucei</i> receptors protected from host antibody‐mediated attack?
How are <i>Trypanosoma brucei</i> receptors protected from host antibody‐mediated attack? Open
Trypanosoma brucei is the causal agent of African Trypanosomiasis in humans and other animals. It maintains a long‐term infection through an antigenic variation based population survival strategy. To proliferate in a mammal, T. brucei acqu…
View article: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surface…
View article: Author response: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Author response: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
View article: Reviewer #1 (Public Review): Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Reviewer #1 (Public Review): Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surface…
View article: Reviewer #3 (Public Review): Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Reviewer #3 (Public Review): Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surface…
View article: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surface…
View article: Author Response: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Author Response: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surface…
View article: Intron-loss in Kinetoplastea correlates with a non-functional EJC and loss of NMD factors
Intron-loss in Kinetoplastea correlates with a non-functional EJC and loss of NMD factors Open
In metazoans, mRNA quality is tightly monitored from transcription to translation. A key role lies with the exon junction complex (EJC) that is placed upstream of the exon-exon junction after splicing. The EJC inner core is composed of Mag…
View article: Trypanosomes and complement: more than one way to die?
Trypanosomes and complement: more than one way to die? Open
View article: Characterization of the major surface glycoconjugates of Trypanosoma theileri
Characterization of the major surface glycoconjugates of Trypanosoma theileri Open
View article: Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae
Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae Open
View article: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are constantly exposed to the molecules of the complement system. This system centres around complement factor C3, which is present in a soluble form in serum but can become…
View article: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surface…
View article: A unique mRNA decapping complex in trypanosomes
A unique mRNA decapping complex in trypanosomes Open
Removal of the mRNA 5′ cap primes transcripts for degradation and is central for regulating gene expression in eukaryotes. The canonical decapping enzyme Dcp2 is stringently controlled by assembly into a dynamic multi-protein complex toget…
View article: Molecular mechanism of complement inhibition by the trypanosome receptor ISG65
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 Open
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surface…
View article: Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei
Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei Open
Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and plant unicellular parasites. Understanding their complex cell architecture and life cycle is challenging because, as with most eukaryotic microbes, ~50% …
View article: Additional file 5 of Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae
Additional file 5 of Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae Open
Additional file 5. Somy levels and repeat content for 50 longest scaffolds from the genome assemblies obtained in this study.
View article: Additional file 1 of Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae
Additional file 1 of Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae Open
Additional file 1. Genome and transcriptome sequencing and assembly statistics. The genomes of C. fasciculata Cf-Cl, L. major Friedlin, T. brucei brucei TREU927 and V. ingenoplastis COLPROT021 are used for comparative purposes.