Thomas M. Conlon
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View article: Cystatin C prevents tissue injury after lung transplantation
Cystatin C prevents tissue injury after lung transplantation Open
Lung transplantation (LTx) offers life-saving therapy for end-stage lung disease, yet primary graft dysfunction (PGD) and bronchiolitis obliterans syndrome remain major complications, which limit long-term outcomes. The risk of PGD increas…
View article: Inhalative polyclonal immunoglobulin G for the prevention of respiratory infections: A comprehensive in vitro assessment
Inhalative polyclonal immunoglobulin G for the prevention of respiratory infections: A comprehensive in vitro assessment Open
Inhalation therapy represents a promising strategy for the delivery of biopharmaceuticals for the local treatment of respiratory diseases. Purified polyclonal serum immunoglobulin G (IgG), also known as IVIg products, exhibit a solid react…
View article: Cell circuits underlying nanomaterial specific respiratory toxicology
Cell circuits underlying nanomaterial specific respiratory toxicology Open
Nanomaterials emerged as boundless resource of innovation, but their shape and biopersistence related to respiratory toxicology raise longstanding concerns. The development of predictive safety tests for inhaled nanomaterials, however, is …
View article: RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD Open
Background Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of regulated cell death (including apoptosis and necroptosis) and inflammation, both drivers of COPD pathogenesis. We aimed to define the contribution of RIPK1 kina…
View article: A transcriptomics-guided drug target discovery strategy identifies receptor ligands for lung regeneration
A transcriptomics-guided drug target discovery strategy identifies receptor ligands for lung regeneration Open
Currently, there is no pharmacological treatment targeting defective tissue repair in chronic disease. Here, we used a transcriptomics-guided drug target discovery strategy using gene signatures of smoking-associated chronic obstructive pu…
View article: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells Open
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2…
View article: Antibiotic use during pregnancy increases offspring asthma severity in a dose‐dependent manner
Antibiotic use during pregnancy increases offspring asthma severity in a dose‐dependent manner Open
Background The use of antibiotics during pregnancy is associated with increased allergic asthma risk in the offspring, and given that approximately 25% of pregnant women are prescribed antibiotics, it is important to understand the mechani…
View article: CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis
CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis Open
Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disease. Although cigarette smoke was considered the main cause of development, the heterogeneous nature of the disease leaves it unclear whether other factors contrib…
View article: Inhibition of B cell–dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation
Inhibition of B cell–dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation Open
Lung transplantation (LTx) is the only therapeutic option for many patients with chronic lung disease. However, long-term survival after LTx is severely compromised by chronic rejection (chronic lung allograft dysfunction [CLAD]), which af…
View article: X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice
X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice Open
The aim of this study was to evaluate the feasibility of early stage imaging of acute lung inflammation in mice using grating-based X-ray dark-field imaging in vivo . Acute lung inflammation was induced in mice by orotracheal instillation …
View article: Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant
Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant Open
Chronic rejection of solid organ allografts remains the major cause of transplant failure. Donor-derived tissue-resident lymphocytes are transferred to the recipient during transplantation, but their impact on alloimmunity is unknown. Usin…