Mark D. Lim
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View article: FIRESTORM I: Stellar Feedback and Gas Kinematics in the Evolved W40 Hub-Filament System
FIRESTORM I: Stellar Feedback and Gas Kinematics in the Evolved W40 Hub-Filament System Open
The FIRESTORM project–Feedback-Induced Regions and Emission from Star-forming Tracers of ObseRvable Molecular Gas–has targeted four star-forming regions to quantify the impact of stellar feedback on star formation. In this paper, we presen…
View article: Neocondylar Formation with Vascularized Fibular Free Flap: A Report of Three Rare Cases and Review of Literature
Neocondylar Formation with Vascularized Fibular Free Flap: A Report of Three Rare Cases and Review of Literature Open
Background: Neocondylar formation is an uncommon finding that can result after the reconstruction of a vascularized free flap. Three case reports were presented in the current article. (1) A 64-year-old male presented with clear cell Odont…
View article: The RAdio Galaxy Environment Reference Survey (RAGERS): Evidence of an anisotropic distribution of submillimeter galaxies in the 4C 23.56 protocluster at z=2.48
The RAdio Galaxy Environment Reference Survey (RAGERS): Evidence of an anisotropic distribution of submillimeter galaxies in the 4C 23.56 protocluster at z=2.48 Open
High-redshift radio(-loud) galaxies (H$z$RGs) are massive galaxies with powerful radio-loud active galactic nuclei (AGNs) and serve as beacons for protocluster identification. However, the interplay between H$z$RGs and the large-scale envi…
View article: Developing Therapies for C3 Glomerulopathy
Developing Therapies for C3 Glomerulopathy Open
Randomized clinical trials are underway to evaluate the efficacy of novel agents targeting the alternative complement pathway in patients with C3 glomerulopathy (C3G), a rare glomerular disease. The Kidney Health Initiative convened a pane…
View article: Development of Non-Spherical Platinum Nanoparticles on Carbon Supports for Oxygen Reduction Reaction
Development of Non-Spherical Platinum Nanoparticles on Carbon Supports for Oxygen Reduction Reaction Open
Proton exchange membrane fuel cells are anticipated to play an important role in decarbonizing the global energy system, but the performance of platinum (Pt) catalysts must be improved to make this technology more economical. Studies have …
View article: Reducing the Risks of Home Dialysis Innovation and Uptake
Reducing the Risks of Home Dialysis Innovation and Uptake Open
"A disruptive innovation is a technologically simple innovation in the form of a product, service, or business model that takes root in a tier of the market that is unattractive to the established leaders in an industry." Clayton M. Christ…
View article: Dried Blood Spots for Global Health Diagnostics and Surveillance: Opportunities and Challenges
Dried Blood Spots for Global Health Diagnostics and Surveillance: Opportunities and Challenges Open
There is increasing interest in using dried blood spot (DBS) cards to extend the reach of global health and disease surveillance programs to hard-to-reach populations. Conceptually, DBS offers a cost-effective solution for multiple use cas…
View article: Diagnostic tools for soil-transmitted helminths control and elimination programs: A pathway for diagnostic product development
Diagnostic tools for soil-transmitted helminths control and elimination programs: A pathway for diagnostic product development Open
Diagnostic tools for soil-transmitted helminths control and elimination programs: A pathway for diagnostic product development
View article: Isotope-labeling derivatization with 3-nitrophenylhydrazine for LC/multiple-reaction monitoring-mass-spectrometry-based quantitation of carnitines in dried blood spots
Isotope-labeling derivatization with 3-nitrophenylhydrazine for LC/multiple-reaction monitoring-mass-spectrometry-based quantitation of carnitines in dried blood spots Open
Carnitines are diagnostic biomarkers of fatty acid oxidation defects and organic acidemias. Quantitative measurements of various carnitines in dried blood spot (DBS) have potential use in remote health applications for disease diagnosis an…
View article: Short-Term Stabilities of 21 Amino Acids in Dried Blood Spots
Short-Term Stabilities of 21 Amino Acids in Dried Blood Spots Open
To the Editor:
Dried blood spot (DBS)1 sampling is used in disease diagnosis, epidemiological surveillance, and newborn screening, and enables sample collection far from analytical laboratories and shipment via mail services. Amino acids …
View article: Short-term stabilities of 21 amino acids in dried blood spots
Short-term stabilities of 21 amino acids in dried blood spots Open
BACKGROUND Dried blood spots (DBSs) have potential use in remote health applications for individual and population diagnosis, and can enable epidemiological surveillance for known and unknown diseases. The preparation and transportation of…
View article: Starting with the End in Mind by Developing Diagnostics around User Needs
Starting with the End in Mind by Developing Diagnostics around User Needs Open
As discussed in this chapter, the commercialization and adoption bottlenecks for these moderately complex diagnostics cannot be overcome by technological innovation alone, particularly in the highly regulated and payer-limited healthcare a…
View article: Philanthropies as partners for drug development in public–private partnerships
Philanthropies as partners for drug development in public–private partnerships Open
Disease-focused philanthropic organizations play an increasing role in the strategy and conduct of biomedical research, with many focusing on drug development for specific diseases and patient populations. More and more they not only provi…