Mark D. White
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View article: Evidence of an activity-enhancing conformational shift in Arabidopsis thaliana plant cysteine oxidase 4 induced by binding of substrate or substrate-mimics
Evidence of an activity-enhancing conformational shift in Arabidopsis thaliana plant cysteine oxidase 4 induced by binding of substrate or substrate-mimics Open
Plant cysteine oxidases (PCOs) are a family of O2-dependent, thiol dioxygenase enzymes that help to coordinate plant responses to flooding by determining the stability of hypoxia-related transcription factors, group VII ethylene…
View article: An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase
An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase Open
N-terminal cysteine oxidases (NCOs) act as enzymatic oxygen (O 2 ) sensors, coordinating cellular changes to hypoxia in animals and plants. They regulate the O 2 -dependent stability of proteins bearing an N-terminal cysteine residue throu…
View article: Tunneling CARs: Increasing CAR T tumor infiltration through the overexpression of <i>MMP7</i> and <i>SPP1</i>
Tunneling CARs: Increasing CAR T tumor infiltration through the overexpression of <i>MMP7</i> and <i>SPP1</i> Open
Chimeric antigen receptor T cell (CART) therapy has demonstrated remarkable efficacy in hematologic malignancies but has struggled to achieve comparable success in solid tumors. A key obstacle is the extracellular matrix (ECM) in solid tum…
View article: The enzymatic oxygen sensor cysteamine dioxygenase binds its protein substrates through their N-termini
The enzymatic oxygen sensor cysteamine dioxygenase binds its protein substrates through their N-termini Open
The non-heme iron-dependent dioxygenase 2-aminoethanethiol (aka cysteamine) dioxygenase (ADO) has recently been identified as an enzymatic oxygen sensor that coordinates cellular changes to hypoxia by regulating the stability of proteins b…
View article: Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors
Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors Open
PURPOSE T cells modified with chimeric antigen receptors (CARTs) have demonstrated efficacy for hematologic malignancies; however, benefit for patients with CNS tumors has been limited. To enhance T cell activity against GD2+ CNS malignanc…
View article: Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets
Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets Open
A large variety of dietary phytochemicals has been shown to improve thrombosis and stroke outcomes in preclinical studies. Many of these compounds feature electrophilic functionalities that potentially undergo covalent addition to the sulf…
View article: Punishment and Resources
Punishment and Resources Open
View article: Introducing Justice and Rights to Students of Economics
Introducing Justice and Rights to Students of Economics Open
View article: Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets
Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets Open
A large variety of dietary phytochemicals have been shown to improve thrombosis and stroke outcomes in preclinical studies. Many of these compounds feature electrophilic functionalities that potentially undergo covalent addition to the sul…
View article: IMMU-15. PHASE I TRIAL OF GD2.CART-CELLS AUGMENTED WITH A CONSTITUTIVELY ACTIVE INTERLEUKIN-7 RECEPTOR (C7R) FOR TREATMENT OF HIGH-GRADE PEDIATRIC CNS TUMORS
IMMU-15. PHASE I TRIAL OF GD2.CART-CELLS AUGMENTED WITH A CONSTITUTIVELY ACTIVE INTERLEUKIN-7 RECEPTOR (C7R) FOR TREATMENT OF HIGH-GRADE PEDIATRIC CNS TUMORS Open
BACKGROUND Treatment of pediatric CNS tumors with T-cells modified with chimeric antigen receptors (CARTs) provides an innovative approach. We employ GD2-directed CART-cells (GD2.CARTs) modified to express a constitutively active interleuk…
View article: Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Although checkpoint inhibitors that block CTLA-4 and PD-1 have improved cancer immunotherapies, targeting additional checkpoint receptors may be required to broaden patient response to immunotherapy. PVRIG is a coinhibitory receptor of the…
View article: Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Figure captions
View article: Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figure Legends from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Figure captions
View article: Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Supplementary Figures and Tables
View article: Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Supplementary Figures and Tables from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Supplementary Figures and Tables
View article: Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function
Data from PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8<sup>+</sup> T-cell Function Open
Although checkpoint inhibitors that block CTLA-4 and PD-1 have improved cancer immunotherapies, targeting additional checkpoint receptors may be required to broaden patient response to immunotherapy. PVRIG is a coinhibitory receptor of the…
View article: Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation
Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation Open
View article: An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor
An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor Open
mRNA display generates vast datasets of protein binders. Bioinformatic clustering of the sequences combined with high throughput synthesis and analysis methods allow efficient prioritisation of hits for in vivo experiments.
View article: Elucidating physicochemical properties of geologic materials using inverse gas chromatography and modeling
Elucidating physicochemical properties of geologic materials using inverse gas chromatography and modeling Open
View article: Structures of <i>Arabidopsis thaliana</i> oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity
Structures of <i>Arabidopsis thaliana</i> oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity Open
Significance The plant cysteine oxidases (PCOs) have been identified as oxygen-sensing enzymes in plants, controlling hypoxia-dependent processes, including adaptive responses to flooding. As such, they are potential targets for engineerin…
View article: Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants Open
Oxygen sensing across kingdoms The ability to sense and respond to changes in oxygen levels is critical for most forms of life. To date, mechanistic studies of this process in mammals have focused on the oxygen-sensitive stability of a tra…
View article: The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry Open
View article: Zinc Excess Induces a Hypoxia-Like Response by Inhibiting Cysteine Oxidases in Poplar Roots
Zinc Excess Induces a Hypoxia-Like Response by Inhibiting Cysteine Oxidases in Poplar Roots Open
Poplar (Populus spp.) is a tree species considered for the remediation of soil contaminated by metals, including zinc (Zn). To improve poplar's capacity for Zn assimilation and compartmentalization, it is necessary to understand the…
View article: Introduction to "The Oxford Handbook of Ethics and Economics"
Introduction to "The Oxford Handbook of Ethics and Economics" Open
Economics and ethics are both valuable tools for analyzing the behavior and actions of human beings and institutions. Adam Smith, the father of modern economics, considered them two sides of the same coin, but since economics was formalize…
View article: Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2
Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2 Open
View article: The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors Open
View article: On the Relationship between Economics and Ethics
On the Relationship between Economics and Ethics Open
Economics and ethics have been linked since the days of Adam Smith, but this connection became tenuous after the formalization of economic theory in the twentieth century, the success of which in academia, government, and business serves t…
View article: The Ethical Issues Behind Expanding the Right to Try Preapproval Drugs and Medical Devices
The Ethical Issues Behind Expanding the Right to Try Preapproval Drugs and Medical Devices Open
View article: The Problems with Measuring and Using Happiness for Policy Purposes
The Problems with Measuring and Using Happiness for Policy Purposes Open
View article: On the Relationship Between Economics and Ethics
On the Relationship Between Economics and Ethics Open