Colin Dayan
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View article: Role of Autoantibody Testing in TED and Graves Diagnosis and Management
Role of Autoantibody Testing in TED and Graves Diagnosis and Management Open
Recent evidence confirms that antibodies to the TSH receptor (TRAb) are central to the pathogenesis of both Graves’ disease itself and TED. Major advances have been made in recent years in the laboratory tests used to measure TRAb levels. …
View article: Autoimmune Type 1 Diabetes in the Era of Disease‐Modifying Immune Therapy
Autoimmune Type 1 Diabetes in the Era of Disease‐Modifying Immune Therapy Open
Disease‐modifying therapies have been used to treat the underlying causes of autoimmune diseases for over half a century. However, until recently, type 1 diabetes (T1D), the autoimmune form of diabetes, had not entered this therapeutic lan…
View article: System Failure in Type 1 Diabetes: What Stakeholders Need to Know to Expedite Therapeutic Options
System Failure in Type 1 Diabetes: What Stakeholders Need to Know to Expedite Therapeutic Options Open
There has been a systemic failure in type 1 diabetes. Regulatory barriers and clinical trial design challenges discourage development of new type 1 diabetes therapies and can compromise the potential for securing approval of new treatments…
View article: Potential cost-effectiveness of childhood screening for type 1 diabetes: Examining reducing Diabetic Ketoacidosis at diagnosis and long-term outcomes to assess the justifiable cost per child screened.
Potential cost-effectiveness of childhood screening for type 1 diabetes: Examining reducing Diabetic Ketoacidosis at diagnosis and long-term outcomes to assess the justifiable cost per child screened. Open
Introduction Diabetic ketoacidosis (DKA) life-threatening emergency that occurs in 38% of children with newly diagnosed type 1 diabetes (T1D) in England and Wales. We conducted a cost-utility analysis to assess the potential cost-effective…
View article: Automated Oral Minimal Models for Rapid Estimation of Insulin Sensitivity and Beta-Cell Responsivity in Large-Scale Data Sets: A Validation Study
Automated Oral Minimal Models for Rapid Estimation of Insulin Sensitivity and Beta-Cell Responsivity in Large-Scale Data Sets: A Validation Study Open
The Oral Minimal Model (OMM) analysis offers unique measures of glucose–insulin regulation during glucose challenges. However, its manual test-by-test implementation limits scalability in large studies. We introduce the Automated Oral Mini…
View article: <b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b>
<b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b> Open
We evaluated whether a binary metabolic endpoint for change (∆) from baseline to 1-year post-randomization could be useful in type 1 diabetes (T1D) prevention trials. Using 2hr-OGTT data from the abatacept prevention trial and similar part…
View article: <b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b>
<b>A Novel Approach for Assessing Outcomes of Type 1 Diabetes Prevention Trials Over a Fixed Time Interval</b> Open
We evaluated whether a binary metabolic endpoint for change (∆) from baseline to 1-year post-randomization could be useful in type 1 diabetes (T1D) prevention trials. Using 2hr-OGTT data from the abatacept prevention trial and similar part…
View article: Risk of Death and Adverse Effects in Patients on Liothyronine: A Multisource Systematic Review and Meta-analysis
Risk of Death and Adverse Effects in Patients on Liothyronine: A Multisource Systematic Review and Meta-analysis Open
Context Although some patients with hypothyroidism prefer combination therapy with liothyronine (LT3) and levothyroxine (LT4), the safety of LT3 remains unresolved. Objective We undertook a multisource systematic review and meta-analysis o…
View article: Clinical Profiles and Medication Predictors in Early Childhood Psychiatric Referrals: A 10-Year Retrospective Study
Clinical Profiles and Medication Predictors in Early Childhood Psychiatric Referrals: A 10-Year Retrospective Study Open
Background and Objectives: Although psychiatric disorders in early childhood are increasingly recognized, comprehensive clinical data from large samples in this age group remain limited. This study presents one of the largest and longest-t…
View article: Testing methods used to predict disease progression in children with early‐stage type 1 diabetes: A systematic review and meta‐analysis
Testing methods used to predict disease progression in children with early‐stage type 1 diabetes: A systematic review and meta‐analysis Open
Aims Current guidance on how best to monitor children and young people (CYP) with early‐stage type 1 diabetes is evidenced mainly by expert consensus. This systematic review and meta‐analysis aims to evaluate the current evidence for tests…
View article: Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure
Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure Open
Context Children born to mothers with gestational thyroid dysfunction may have an increased risk of adverse neurodevelopmental outcomes, but the effects of maternal thyroid function on brain microstructure are unknown. Objective To establi…
View article: The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT
The efficacy and safety of ustekinumab in adolescents newly diagnosed with type 1 diabetes: the USTEK1D RCT Open
Background Type 1 diabetes is an autoimmune disease affecting over 400,000 children and adults in the United Kingdom for which currently the only available therapy is insulin. Objective(s) To determine the efficacy and safety of the monocl…
View article: How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?
How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment? Open
Introduction There continues to be much discussion around optimisation of thyroid hormone status in hypothyroid individuals. We here looked the way that free T4(FT4) and thyroid‐stimulating hormone (TSH) related to each other in a large la…
View article: Protocol for a feasibility and acceptability study for <scp>UK</scp> general population paediatric type 1 diabetes screening—the <scp>EarLy</scp> Surveillance for Autoimmune diabetes (<scp>ELSA</scp>) study
Protocol for a feasibility and acceptability study for <span>UK</span> general population paediatric type 1 diabetes screening—the <span>EarLy</span> Surveillance for Autoimmune diabetes (<span>ELSA</span>) study Open
Aim The EarLy Surveillance for Autoimmune (ELSA) study aims to explore the feasibility and acceptability of UK paediatric general population screening for type 1 diabetes. Methods We aim to screen 20,000 children aged 3–13 years for islet‐…
View article: Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial
Investigating the effect of verapamil on preservation of beta-cell function in adults with newly diagnosed type 1 diabetes mellitus (Ver-A-T1D): protocol for a randomised, double-blind, placebo-controlled, parallel-group, multicentre trial Open
Introduction Type 1 diabetes mellitus (T1DM) is a disorder that arises following the selective autoimmune destruction of the insulin-producing beta cells. Beta-cell protective or beta-cell regenerative approaches have gained wider attentio…
View article: A study to determine a capillary alternative to the gold standard oral glucose tolerance test - Protocol
A study to determine a capillary alternative to the gold standard oral glucose tolerance test - Protocol Open
Type 1 diabetes (T1D) is a chronic condition caused by the immune destruction of the pancreatic beta cells. T1D has recognised asymptomatic pre-clinical stages, providing an opportunity for early diagnosis, education and treatment which ma…
View article: General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study)
General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study) Open
Objective Type 1 diabetes (T1D) screening programmes testing islet autoantibodies (IAbs) in childhood can reduce life-threatening diabetic ketoacidosis. General population screening is required to detect the majority of children with T1D, …
View article: Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Adolescent Brain Morphology
Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Adolescent Brain Morphology Open
Context Children born to mothers with gestational hypothyroidism or hyperthyroidism may have increased risk of adverse neurodevelopmental outcomes. However, the effects of maternal thyroid status on offspring brain development are unclear.…
View article: Residual humanism
Residual humanism Open
Looking at non-human animals as our kin, appealing to our heart and enlarging our capacity to imagine, I offer another way of thinking, more dependent on feeling than reason. Not sympathy or sentiment, but instead a unique way of being-in-…
View article: The Race for New Treatments for Graves Orbitopathy (Thyroid Eye Disease)
The Race for New Treatments for Graves Orbitopathy (Thyroid Eye Disease) Open
Journal Article Corrected proof The Race for New Treatments for Graves Orbitopathy (Thyroid Eye Disease) Get access Colin M Dayan Colin M Dayan Thyroid Research Group, Division of Infection and Immunity, Cardiff University School of Medici…
View article: Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment
Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment Open
Citation: Bianco AC, Dayan CM and Jonklaas J (2024) Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment. Front. Endocrinol. 15:1369723. doi: 10.3389/fendo.2024.1369723
View article: Natural desiccated thyroid for the treatment of hypothyroidism?
Natural desiccated thyroid for the treatment of hypothyroidism? Open
Primary hypothyroidism affects about 3% of the general population in Europe. Early treatments in the late 19 th Century involved subcutaneous as well as oral administration of thyroid extract. Until the early 1970s, the majority of people …
View article: Designing a combined liothyronine (LT3), L- thyroxine (LT4) trial in symptomatic hypothyroid subjects on LT4 - the importance of patient selection, choice of LT3 and trial design
Designing a combined liothyronine (LT3), L- thyroxine (LT4) trial in symptomatic hypothyroid subjects on LT4 - the importance of patient selection, choice of LT3 and trial design Open
Approximately 10%–15% of subjects with hypothyroidism on L-thyroxine (LT4) alone have persistent symptoms affecting their quality of life (QoL). Although the cause is unclear, there is evidence that “tissue T3 lack” may be responsible. If …