Mark Dedden
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View article: Single-cell dissection of cell hierarchies in urine-derived stem cells – application to chondrogenesis and general scalability
Single-cell dissection of cell hierarchies in urine-derived stem cells – application to chondrogenesis and general scalability Open
Developing of models of human cartilage and bone growth is essential for the study of growth disorders and to advance towards personalized therapeutic interventions. The majority of in vitro strategies depend on the use of invasively obtai…
View article: Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice
Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice Open
Lung tissue-resident memory T cells (T RM ) are critical for the local control of respiratory tract infections caused by influenza A viruses (IAV). Here we compare T RM populations induced by intranasal adenoviral vector vaccines encoding …
View article: Etrolizumab-s fails to control E-Cadherin-dependent co-stimulation of highly activated cytotoxic T cells
Etrolizumab-s fails to control E-Cadherin-dependent co-stimulation of highly activated cytotoxic T cells Open
View article: IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells Open
IL-3 has been reported to be involved in various inflammatory disorders, but its role in inflammatory bowel disease (IBD) has not been addressed so far. Here, we determined IL-3 expression in samples from patients with IBD and studied the …
View article: Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney
Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney Open
Adhesion G protein-coupled receptors (aGPCRs) comprise the second-largest class of GPCRs, the most common target for approved pharmacological therapies. aGPCRs play an important role in development and disease and have recently been associ…
View article: IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells Open
RNA from unchallenged mouse Il3r-/- and Il3r+/+ thymocytes was isolated with the NucleoSpin RNA Kit for RNA isolation (Machery Nagel). RNA-Analysis and sequencing was performed by the Core unit next …
View article: IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells Open
RNA from unchallenged mouse Il3r-/- and Il3r+/+ thymocytes was isolated with the NucleoSpin RNA Kit for RNA isolation (Machery Nagel). RNA-Analysis and sequencing was performed by the Core unit next …
View article: Manual cell selection in single cell transcriptomics using scSELpy supports the analysis of immune cell subsets
Manual cell selection in single cell transcriptomics using scSELpy supports the analysis of immune cell subsets Open
Introduction Single cell RNA sequencing plays an increasing and indispensable role in immunological research such as in the field of inflammatory bowel diseases (IBD). Professional pipelines are complex, but tools for the manual selection …
View article: Anti‐β7 integrin treatment impedes the recruitment on non‐classical monocytes to the gut and delays macrophage‐mediated intestinal wound healing
Anti‐β7 integrin treatment impedes the recruitment on non‐classical monocytes to the gut and delays macrophage‐mediated intestinal wound healing Open
Background Closing mucosal defects to reach mucosal healing is an important goal of therapy in inflammatory bowel disease (IBD). Among other cells, monocyte‐derived macrophages are centrally involved in such intestinal wound healing. We ha…
View article: P009 IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
P009 IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells Open
Background The pathogenesis of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) is still incompletely understood. However, despite having been described back in the 1980s and reported to be involve…
View article: Increased Motility and Suppression of Ex Vivo–Expanded Regulatory T Cells Designed for Adoptive Transfer Therapy in Ulcerative Colitis
Increased Motility and Suppression of Ex Vivo–Expanded Regulatory T Cells Designed for Adoptive Transfer Therapy in Ulcerative Colitis Open
View article: CRISPR-Cas9-mediated genome editing in vancomycin-resistant <i>Enterococcus faecium</i>
CRISPR-Cas9-mediated genome editing in vancomycin-resistant <i>Enterococcus faecium</i> Open
The Gram-positive bacterium Enterococcus faecium is becoming increasingly prevalent as a cause of hospital-acquired, antibiotic-resistant infections. A fundamental part of research into E. faecium biology relies on the ability to generate …
View article: CRISPR-Cas9 mediated genome editing in vancomycin resistant<i>Enterococcus faecium</i>
CRISPR-Cas9 mediated genome editing in vancomycin resistant<i>Enterococcus faecium</i> Open
The Gram-positive bacterium Enterococcus faecium is becoming increasingly prevalent as a cause of hospital-acquired, antibiotic-resistant infections. There is thus an urgent need to mechanistically characterize the traits that contribute t…