Martin Dennis
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View article: Impact of Rurality and Geographical Accessibility on Stroke Care and Outcomes
Impact of Rurality and Geographical Accessibility on Stroke Care and Outcomes Open
BACKGROUND: Providing equitable health care to rural stroke patients is challenging and associated with less intervention and poorer outcomes. We assessed how several distinct patient-related geographic classifications influenced stroke ca…
View article: A systematic review of current national hospital-based stroke registries monitoring access to evidence-based care and patient outcomes
A systematic review of current national hospital-based stroke registries monitoring access to evidence-based care and patient outcomes Open
Background: National stroke clinical quality registries/audits support improvements in stroke care. In a 2016 systematic review, 28 registries were identified. Since 2016 there have been important advances in stroke care, including the dev…
View article: Fluoxetine and fractures after stroke: An individual patient data meta-analysis of three large randomized controlled trials of fluoxetine for stroke recovery
Fluoxetine and fractures after stroke: An individual patient data meta-analysis of three large randomized controlled trials of fluoxetine for stroke recovery Open
Background: Observational studies have shown that selective serotonin reuptake inhibitors are associated with an increased risk of bone fractures, but the association can be confounded by indication and other sources of systematic bias tha…
View article: Implementation of a shared decision making process for severe stroke-a mixed methods study
Implementation of a shared decision making process for severe stroke-a mixed methods study Open
Purpose Clinical decisions made early after stroke can make the difference between survival with disability or death. We aimed to develop, implement and evaluate a new Shared decision making (SDM) process for severe stroke into a regional …
View article: Individual patient data meta-analysis of the effects of fluoxetine on functional outcomes after acute stroke
Individual patient data meta-analysis of the effects of fluoxetine on functional outcomes after acute stroke Open
Background: Three large randomized controlled trials of fluoxetine for stroke recovery have been performed. We performed an individual patient data meta-analysis (IPDM) on the combined data. Methods: Fixed effects meta-analyses were perfor…
View article: Implementation of a shared decision making process for severe stroke-a mixed methods study
Implementation of a shared decision making process for severe stroke-a mixed methods study Open
Background Clinical decisions made early after stroke can make the difference between survival with disability or death. We aimed to develop, implement and evaluate a new Shared decision making (SDM) process for severe stroke into a region…
View article: Clinical Diagnosis and Magnetic Resonance Imaging in Patients With Transient and Minor Neurological Symptoms: A Prospective Cohort Study
Clinical Diagnosis and Magnetic Resonance Imaging in Patients With Transient and Minor Neurological Symptoms: A Prospective Cohort Study Open
Background: The utility of magnetic resonance imaging (MRI) brain in patients with transient or minor neurological symptoms is uncertain. We sought to determine the proportion of participants with transient or minor neurological symptoms w…
View article: Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke: AFFINITY Study Findings
Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke: AFFINITY Study Findings Open
Background Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely underst…
View article: <sup>18</sup>F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome
<sup>18</sup>F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome Open
Background MRI and fluorine 18-labeled sodium fluoride (18F-NaF) PET can be used to identify features of plaque instability, rupture, and disease activity, but large studies have not been performed. Purpose To evaluate the association betw…
View article: Electronic Informed Consent: effects on enrolment, practical and economic benefits, challenges, and drawbacks. Studies within Randomised Controlled Trials. Systematic Review.
Electronic Informed Consent: effects on enrolment, practical and economic benefits, challenges, and drawbacks. Studies within Randomised Controlled Trials. Systematic Review. Open
Background Enrolment is one of the most challenging aspects of conducting clinical trials, preceded by the process of informed consent (IC). Different strategies to improve recruitment in clinical trials have been used, including electroni…
View article: Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage
Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage Open
isrctn.org Identifier: ISRCTN71907627.
View article: Effects of Fluoxetine on Outcomes at 12 Months After Acute Stroke
Effects of Fluoxetine on Outcomes at 12 Months After Acute Stroke Open
Background and Purpose: The EFFECTS (Efficacy of Fluoxetine—a Randomised Controlled Trial in Stroke) recently reported that 20 mg fluoxetine once daily for 6 months after acute stroke did not improve functional outcome but reduced depressi…
View article: Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery
Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery Open
http://anzctr.org.au Identifier: ACTRN12611000774921.
View article: European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA
European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA Open
Prevention of early recurrent ischaemic stroke remains a priority in people with TIA or ischaemic stroke. A number of trials have recently been completed assessing the efficacy of short-term dual antiplatelet therapy (DAPT) versus single a…
View article: Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration
Twelve-Month Outcomes of the AFFINITY Trial of Fluoxetine for Functional Recovery After Acute Stroke: AFFINITY Trial Steering Committee on Behalf of the AFFINITY Trial Collaboration Open
Background and Purpose: The AFFINITY trial (Assessment of Fluoxetine in Stroke Recovery) reported that oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fra…
View article: European Stroke Organisation (ESO) guidelines on management of transient ischaemic attack
European Stroke Organisation (ESO) guidelines on management of transient ischaemic attack Open
The aim of the present European Stroke Organisation Transient Ischaemic Attack (TIA) management guideline document is to provide clinically useful evidence-based recommendations on approaches to triage, investigation and secondary preventi…
View article: European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA
European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA Open
Prevention of early recurrent ischaemic stroke remains a priority in people with TIA or ischaemic stroke. A number of trials have recently been completed assessing the efficacy of short-term dual antiplatelet therapy (DAPT) versus single a…
View article: Predicting specific abilities after disabling stroke: Development and validation of prognostic models
Predicting specific abilities after disabling stroke: Development and validation of prognostic models Open
Background Predicting specific abilities (e.g. walk and talk) to provide a functional profile six months after disabling stroke could help patients/families prepare for the consequences of stroke and facilitate involvement in treatment dec…
View article: Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study
Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study Open
Background Hospital-based studies have reported variable associations between outcome after spontaneous intracerebral hemorrhage and peri-hematomal edema volume. Aims In a community-based study, we aimed to investigate the existence, stren…
View article: Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial
Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial Open
Objectives Informing research participants of the results of studies in which they took part is viewed as an ethical imperative. However, there is little guidance in the literature about how to do this. The Fluoxetine Or Control Under Supe…
View article: Venous thromboembolism prevention in intracerebral hemorrhage: A systematic review and network meta-analysis
Venous thromboembolism prevention in intracerebral hemorrhage: A systematic review and network meta-analysis Open
PROSPERO: CRD42018090960.
View article: Telemedicine Cognitive Behavioral Therapy for Anxiety After Stroke
Telemedicine Cognitive Behavioral Therapy for Anxiety After Stroke Open
Background and Purpose: Disabling anxiety affects a quarter of stroke survivors but access to treatment is poor. We developed a telemedicine model for delivering guided self-help cognitive behavioral therapy (CBT) for anxiety after stroke …