Mark Dexter
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View article: Harnessing liquid biopsy to unveil RAS-MEK pathway somatic pathogenic variants in extracranial arterio-venous malformations
Harnessing liquid biopsy to unveil RAS-MEK pathway somatic pathogenic variants in extracranial arterio-venous malformations Open
Background Arterio-venous malformations (AVMs) have been associated with somatic genetic variants in the RAS-MEK pathway, generating interest in the role of MEK inhibitors. However, open biopsy for molecular characterisation carries a pote…
View article: Investigating mutual coupling in the hydrogen epoch of reionization array and mitigating its effects on the 21-cm power spectrum
Investigating mutual coupling in the hydrogen epoch of reionization array and mitigating its effects on the 21-cm power spectrum Open
Interferometric experiments designed to detect the highly redshifted 21-cm signal from neutral hydrogen are producing increasingly stringent constraints on the 21-cm power spectrum, but some k-modes remain systematics-dominated. Mutual cou…
View article: Assessing the clinical application of the PANOMEN 3 classification in a large cohort of pituitary tumors
Assessing the clinical application of the PANOMEN 3 classification in a large cohort of pituitary tumors Open
Objective Pituitary tumors are a heterogeneous group of neoplasms exhibiting a wide range of clinical and histological features. There are currently no comprehensive clinically validated prognostic tools to guide management of all tumor ty…
View article: Cerebral Proliferative Arteriopathy Secondary to Extracranial Carotid Stenosis
Cerebral Proliferative Arteriopathy Secondary to Extracranial Carotid Stenosis Open
Cerebral proliferative arteriopathy (CPA) is a rare vascular malformation distinct from arteriovenous malformations. Although arterial stenoses in CPA are thought to develop later, we hypothesize some cases may result from preexisting sten…
View article: Middle meningeal artery embolization for chronic subdural hematoma
Middle meningeal artery embolization for chronic subdural hematoma Open
Objectives To assess recurrence rates, procedural outcomes and patient outcomes following middle meningeal artery (MMA) embolization for the treatment of chronic subdural hematomas (cSDH). Design Retrospective case series. Setting Two tert…
View article: Aristotle wires for cannulating target vessels in paediatric neuro-interventional procedures: A case-control study
Aristotle wires for cannulating target vessels in paediatric neuro-interventional procedures: A case-control study Open
Background Paediatric neuro-interventional (PNI) procedures are markedly different to adult procedures and are more likely to be complicated by vasospasm. Traversing the complex tortuous anatomy in these fragile vessels requires both torqu…
View article: Mitigating calibration errors from mutual coupling with time-domain filtering of 21 cm cosmological radio observations
Mitigating calibration errors from mutual coupling with time-domain filtering of 21 cm cosmological radio observations Open
The 21 cm transition from neutral Hydrogen promises to be the best observational probe of the Epoch of Reionization (EoR). This has led to the construction of low-frequency radio interferometric arrays, such as the Hydrogen Epoch of Reioni…
View article: Macroprolactinoma in an adolescent female with primary amenorrhoea
Macroprolactinoma in an adolescent female with primary amenorrhoea Open
Summary Paediatric pituitary adenomas are rare in children and adolescents and differ from adults in both clinical presentation and management. We present the case of a 14-year-old female with primary amenorrhoea secondary to a macroprolac…
View article: Mitigating calibration errors from mutual coupling with time-domain filtering of 21 cm cosmological radio observations
Mitigating calibration errors from mutual coupling with time-domain filtering of 21 cm cosmological radio observations Open
The 21 cm transition from neutral Hydrogen promises to be the best observational probe of the Epoch of Reionisation (EoR). This has led to the construction of low-frequency radio interferometric arrays, such as the Hydrogen Epoch of Reioni…
View article: From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients
From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients Open
Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by HIST1H3B and HIST1H3C) and H3.3 (encoded by H3F3A), are mainly associated with pediatric b…
View article: Somatostatin receptor expression and clinical outcome of multilineage pituitary tumours expressing PIT1 and SF1
Somatostatin receptor expression and clinical outcome of multilineage pituitary tumours expressing PIT1 and SF1 Open
The application of transcription factor immunohistochemistry to pituitary neuroendocrine tumour (PitNET) assessment has allowed identification of tumours that do not conform to a single lineage. Multilineage pituitary transcription factor …
View article: Endovascular and microsurgical management of blister aneurysms: a multi-centre review
Endovascular and microsurgical management of blister aneurysms: a multi-centre review Open
Background Blister aneurysms (BA) are high risk cerebrovascular lesions accounting for 1% of intracranial aneurysms. The defective vessel wall and broad-based neck make this clinical entity difficult to treat, with high rates of re-rupture…
View article: Localisation and stimulation of the parietal eye field<sup>*</sup>
Localisation and stimulation of the parietal eye field<sup>*</sup> Open
Localisation of the human parietal eye fields (PEF) has not been as well studied as the human frontal eye fields (FEF). Stimulation studies in rhesus monkeys have suggested the localisation of the PEF to be within the intraparietal sulcus.…
View article: Investigating the Precise Localization of the Grasping Action in the Mid-Cingulate Cortex and Future Directions
Investigating the Precise Localization of the Grasping Action in the Mid-Cingulate Cortex and Future Directions Open
Objective To prospectively study the cingulate cortex for the localization and role of the grasping action in humans during electrical stimulation of depth electrodes. Methods All the patients ( n = 23) with intractable focal epilepsy and …
View article: The Effect of Bevacizumab on Vestibular Schwannoma Related to Neurofibromatosis Type 2
The Effect of Bevacizumab on Vestibular Schwannoma Related to Neurofibromatosis Type 2 Open
Introduction: We describe an Australian experience of infusional bevacizumab for vestibular schwannoma (VS) in neurofibromatosis type 2 patients, with specific focus on 3-dimensional tumour volume and audiometry. Method: Data was pooled fr…
View article: Successful epilepsy surgery for tuberous sclerosis complex evaluated by stereoelectroencephalography
Successful epilepsy surgery for tuberous sclerosis complex evaluated by stereoelectroencephalography Open
Evaluating the candidacy for epilepsy surgery in patients with tuberous sclerosis can be challenging, particularly when non‐invasive investigations do not show a clear epileptogenic zone. Stereoencephalography may be useful in such cases. …
View article: Failure of platelet function analyser 200 to demonstrate clinical clopidogrel resistance in a patient undergoing intracranial vascular stenting
Failure of platelet function analyser 200 to demonstrate clinical clopidogrel resistance in a patient undergoing intracranial vascular stenting Open
A patient undergoes intracranial stent insertion for stent-assisted coiling of a basilar tip aneurysm and left middle cerebral artery aneurysm. A flow diverting stent is also placed across an anterior communicating artery aneurysm. Prior t…
View article: Driving innovation through collaboration: development of clinical annotation datasets for brain cancer biobanking
Driving innovation through collaboration: development of clinical annotation datasets for brain cancer biobanking Open
Background A key component of cancer research is the availability of clinical samples with appropriately annotated clinical data. Biobanks facilitate research by collecting/storing various types of clinical samples for research. Brain Canc…
View article: The varied semiology of seizures in the context of small anterior temporal encephaloceles
The varied semiology of seizures in the context of small anterior temporal encephaloceles Open
Aims . Small encephaloceles of the anterior temporal pole have been increasingly recognised as an underlying epileptogenic substrate in patients with medically refractory epilepsy. The current report aims to expand on the current knowledge…
View article: Rasmussen encephalitis tissue transfer program
Rasmussen encephalitis tissue transfer program Open
Rasmussen encephalitis (RE) was first described in 1958 by Theodore Rasmussen and colleagues at the Montreal Neurological Institute. RE is a very rare neuro-inflammatory disease characterized by intractable seizures and progressive unilate…