Mark Dulchavsky
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View article: P872: Hospitalization of patients with organic acidemias: Clinical characteristics and economic evaluation
P872: Hospitalization of patients with organic acidemias: Clinical characteristics and economic evaluation Open
Exciting advances in strategies for mRNA delivery, gene editing, and gene therapy have accelerated the development of drugs for treatment of genetic diseases. Unfortunately, the prodigious expense and challenge in obtaining broad insurance…
View article: Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme
Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme Open
The flavoenzyme nicotine oxidoreductase (NicA2) is a promising injectable treatment to aid in the cessation of smoking, a behavior responsible for one in ten deaths worldwide. NicA2 acts by degrading nicotine in the bloodstream before it r…
View article: Surfaces Coated with Polymer Brushes Work as Carriers for Histidine Ammonia Lyase
Surfaces Coated with Polymer Brushes Work as Carriers for Histidine Ammonia Lyase Open
The immobilization of enzymes on solid supports is an important challenge in biotechnology and biomedicine. In contrast to other methods, enzyme deposition in polymer brushes offers the benefit of high protein loading that preserves enzyma…
View article: Directed evolution unlocks oxygen reactivity for a nicotine degrading flavoenzyme
Directed evolution unlocks oxygen reactivity for a nicotine degrading flavoenzyme Open
Data included in the publication "Directed evolution unlocks oxygen reactivity for a nicotine degrading flavoenzyme"
View article: The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase
The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase Open
The soil-dwelling bacterium Pseudomonas putida S16 can survive on nicotine as its sole carbon and nitrogen source. The enzymes nicotine oxidoreductase (NicA2) and pseudooxynicotine amine oxidase (Pnao), both members of the flavin-containin…
View article: Microreactor equipped with naturally acid-resistant histidine ammonia lyase from an extremophile
Microreactor equipped with naturally acid-resistant histidine ammonia lyase from an extremophile Open
Encapsulation of an extremophile histidine ammonia lyase into a photo-crosslinked polyvinyl-alcohol hydrogel allowed it to retain substantial activity following exposure to simulated digestive fluids.
View article: Characterization and Improvement of a Nicotine-Degrading Flavoenzyme
Characterization and Improvement of a Nicotine-Degrading Flavoenzyme Open
Nicotine oxidoreductase (NicA2) is a flavin-dependent enzyme that has the ability to catalyze oxidation of nicotine to N-methylmyosmine. Though nicotine is a psychoactive substance with high addictive potential, N-methylmyosmine is not. Du…
View article: Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly
Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly Open
Significance UBQLN2, a ubiquitin-linked quality-control protein, accumulates in common neurodegenerative diseases and, when mutated, directly causes neurodegeneration. Employing a range of model systems, we show that UBQLN2 is intrinsicall…
View article: P3‐152: INVESTIGATING THE ROLE OF UBIQUILIN2 IN AGE‐RELATED NEURODEGENERATION
P3‐152: INVESTIGATING THE ROLE OF UBIQUILIN2 IN AGE‐RELATED NEURODEGENERATION Open
Ubiquilins (UBQLNs) are a family of highly homologous proteins that shuttle polyubiquitinated proteins to the proteasome for degradation and clearance. The more widely studied UBQLN1 has been shown to co-precipitate in protein deposits fou…
View article: [P2–165]: INVESTIGATING THE ROLE OF UBIQUILIN2 IN AGE‐RELATED NEURODEGENERATION
[P2–165]: INVESTIGATING THE ROLE OF UBIQUILIN2 IN AGE‐RELATED NEURODEGENERATION Open
Brain accumulation of Ubiquilin2 (UBQLN2) is a shared feature of neurodegenerative diseases including Alzheimer's disease, Lewy Body Dementia, Frontotemporal Dementia (FTD) and polyglutamine expansion disorders such as Huntington disease (…
View article: Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity
Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity Open
Hexanucleotide repeat expansions in C9orf72 are the most common inherited cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expansions elicit toxicity in part through repeat-associated non-AUG (RAN) transl…
View article: Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3
Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3 Open
No disease-modifying treatment exists for the fatal neurodegenerative polyglutamine disease known both as Machado-Joseph disease and spinocerebellar ataxia type 3. As a potential route to therapy, we identified small molecules that reduce …
View article: O2‐06‐05: Toward understanding pathogenesis of ubqln2‐mediated ftd/als
O2‐06‐05: Toward understanding pathogenesis of ubqln2‐mediated ftd/als Open
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