Mark Dunning
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View article: Human amyotrophic lateral sclerosis/motor neuron disease: The disease‐associated microglial pathway is upregulated while <i>APOE</i> genotype governs risk and survival
Human amyotrophic lateral sclerosis/motor neuron disease: The disease‐associated microglial pathway is upregulated while <i>APOE</i> genotype governs risk and survival Open
A key role for inflammation in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) has been identified. It is vital to assess which central nervous system structures are most affected and which inflammatory processes are responsib…
View article: Selecting differential splicing methods: Practical considerations for short-read RNA sequencing
Selecting differential splicing methods: Practical considerations for short-read RNA sequencing Open
Alternative splicing is crucial in gene regulation, with significant implications in clinical settings and biotechnology. This review article compiles bioinformatics short-read RNA-seq tools for investigating differential splicing; offerin…
View article: TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques
TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques Open
Atherosclerosis progresses from fatty streaks to complex plaques, with rupture leading to life-threatening complications. Endothelial-to-mesenchymal transition (EndMT) is associated with advanced atherosclerotic plaques, but its role in pl…
View article: Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated and APOE ε2 is protective
Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated and APOE ε2 is protective Open
A key role for inflammation in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) has been identified. It is vital to assess which central nervous system structures are most affected and which inflammatory processes are responsib…
View article: Selecting differential splicing methods: Practical considerations
Selecting differential splicing methods: Practical considerations Open
Alternative splicing is crucial in gene regulation, with significant implications in clinical settings and biotechnology. This review article compiles bioinformatics RNA-seq tools for investigating differential splicing; offering a detaile…
View article: Ex-vivo models of post-surgical residual disease in human glioblastoma
Ex-vivo models of post-surgical residual disease in human glioblastoma Open
Background Glioblastoma is a highly infiltrative, currently incurable brain cancer. To date, translation of novel therapies for glioblastoma from the laboratory into clinical trials has relied heavily on in vitro cell culture and murine (s…
View article: Selecting Differential Splicing Methods: Practical Considerations
Selecting Differential Splicing Methods: Practical Considerations Open
Alternative splicing is crucial in gene regulation, with significant implications in clinical settings and biotechnology. This review article compiles bioinformatics RNA-seq tools for investigating differential splicing; offering a detaile…
View article: EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake Open
BACKGROUND: Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription fa…
View article: CBP-IDRs regulate acetylation and gene expression
CBP-IDRs regulate acetylation and gene expression Open
Intrinsically disordered regions (IDRs) have emerged as crucial regulators of protein function, allowing proteins to sense and respond to their environment. Creb binding protein (CBP) and EP300 (p300) are transcription coactivators that re…
View article: EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake
EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake Open
Background Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription fac…
View article: Multimodal assessment of mitochondrial function in Parkinson's disease
Multimodal assessment of mitochondrial function in Parkinson's disease Open
The heterogenous aetiology of Parkinson's disease is increasingly recognized; both mitochondrial and lysosomal dysfunction have been implicated. Powerful, clinically applicable tools are required to enable mechanistic stratification for fu…
View article: DEfiNING SPATIAL HETEROGENEITY OF A NOVEL LIVING BIOBANK OF POST-SURGICAL RESIDUAL GLIOBLASTOMA TO DEVELOP STRATEGIES FOR TARGETED THERAPY
DEfiNING SPATIAL HETEROGENEITY OF A NOVEL LIVING BIOBANK OF POST-SURGICAL RESIDUAL GLIOBLASTOMA TO DEVELOP STRATEGIES FOR TARGETED THERAPY Open
AIMS Glioblastoma is the most common cancer arising within the brain accounting for >2,000 deaths/year in the UK. Current standard-of-care therapy consists of maximal safe surgical resection followed by radiochemotherapy which activates…
View article: Regulation of cellular contractile force, shape and migration of fibroblasts by oncogenes and Histone deacetylase 6
Regulation of cellular contractile force, shape and migration of fibroblasts by oncogenes and Histone deacetylase 6 Open
The capacity of cells to adhere to, exert forces upon and migrate through their surrounding environment governs tissue regeneration and cancer metastasis. The role of the physical contractile forces that cells exert in this process, and th…
View article: A Double‐Blind, Randomized, Placebo‐Controlled Trial of Ursodeoxycholic Acid (<scp>UDCA)</scp> in Parkinson's Disease
A Double‐Blind, Randomized, Placebo‐Controlled Trial of Ursodeoxycholic Acid (<span>UDCA)</span> in Parkinson's Disease Open
Background Rescue of mitochondrial function is a promising neuroprotective strategy for Parkinson's disease (PD). Ursodeoxycholic acid (UDCA) has shown considerable promise as a mitochondrial rescue agent across a range of preclinical in v…
View article: Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency
Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency Open
Heterozygous variants in GBA1, encoding glucocerebrosidase (GCase), are the most common genetic risk factor for Parkinson's disease (PD). Moreover, sporadic PD patients also have a substantial reduction of GCase activity. Genetic variants …
View article: SpheroidAnalyseR—an online platform for analyzing data from 3D spheroids or organoids grown in 96-well plates
SpheroidAnalyseR—an online platform for analyzing data from 3D spheroids or organoids grown in 96-well plates Open
Spheroids and organoids are increasingly popular three-dimensional (3D) cell culture models. Spheroid models are more physiologically relevant to a tumor compared to two-dimensional (2D) cultures and organoids are a simplified version of a…
View article: STEM-02. GENERATION AND CHARACTERISATION OF A LIVING BIOBANK OF POST-SURGICAL RESIDUAL GLIOBLASTOMA TO IDENTIFY NOVEL THERAPEUTIC TARGETS
STEM-02. GENERATION AND CHARACTERISATION OF A LIVING BIOBANK OF POST-SURGICAL RESIDUAL GLIOBLASTOMA TO IDENTIFY NOVEL THERAPEUTIC TARGETS Open
Glioblastoma is the most common cancer arising within the brain and contributes to ~190,000 brain tumour related deaths/year globally. Current standard-of-care therapy consists of maximal safe surgical resection, radiotherapy with concomit…
View article: JAG1-NOTCH4 mechanosensing drives atherosclerosis
JAG1-NOTCH4 mechanosensing drives atherosclerosis Open
Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arteries that causes heart attack and stroke, through poorly defined mechanisms. The Notch pathway plays a central role in blood vessel growth and…
View article: Identification and pedigree analysis of LHX3-associated dwarfism in a large cohort of UK Tibetan Terriers
Identification and pedigree analysis of LHX3-associated dwarfism in a large cohort of UK Tibetan Terriers Open
Clinical abstract presented at BSAVA Congress 2022. See full text for abstract and see clinical abstract sessions for a recording of the presentation. Abstracts are presented as supplied and have not been edited.
View article: Pituitary Dwarfism in Tibetan Terriers, a newly identified genetic disorder
Pituitary Dwarfism in Tibetan Terriers, a newly identified genetic disorder Open
Clinical abstract presented at BSAVA Congress 2022. See full text for abstract and see clinical abstract sessions for a recording of the presentation. Abstracts are presented as supplied and have not been edited.
View article: Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo
Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo Open
Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets. This study aims to clarify the role of the extrac…
View article: SpheroidAnalyseR – an online platform for analysing data from 3D spheroids or organoids grown in 96-well plates
SpheroidAnalyseR – an online platform for analysing data from 3D spheroids or organoids grown in 96-well plates Open
Spheroids and organoids are increasingly popular three-dimensional (3D) cell culture models. Spheroid models are more physiologically relevant to a tumour compared to two-dimensional (2D) cultures and organoids are a simplified version of …
View article: Quality Control and Low-Level Statistical Analysis of Illumina BeadArray
Quality Control and Low-Level Statistical Analysis of Illumina BeadArray Open
The Illumina BeadArrayTM platform is a novel microarray technology based on randomly assembled arrays of beads. Each bead on the array carries copies of a single gene-specific probe with, on average, about 30 replicates of each bead type o…