Mark E. B. Smith
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View article: Stability and Rheological Characteristics of <scp>UHMWPE</scp>/Paraffin Oil Thermo‐Reversible Sols, Obtained via Twin Screw Extrusion
Stability and Rheological Characteristics of <span>UHMWPE</span>/Paraffin Oil Thermo‐Reversible Sols, Obtained via Twin Screw Extrusion Open
In this study, we produced UH‐PO sols using twin screw extrusion and characterized their thermal and rheological properties to evaluate changes induced by composition variation and extrusion process parameters. Extruder screw configuration…
View article: Puncture evaluation of radiological gloves to assess use performance
Puncture evaluation of radiological gloves to assess use performance Open
Tensile testing of gloves is an accepted method for the qualification of a new glove material or the qualification of a production run. Most often these tests are performed in accordance to ASTM standards, i.e. - D412-98a Standard Test Met…
View article: Design, chemical synthesis and antiviral evaluation of 2′-deoxy-2′-fluoro-2′-C-methyl-4′-thionucleosides
Design, chemical synthesis and antiviral evaluation of 2′-deoxy-2′-fluoro-2′-C-methyl-4′-thionucleosides Open
Nucleoside analogues represent an historically accomplished class of antiviral drug. Notwithstanding this, new molecular scaffolds are required to overcome their limitations and evolve pharmacophore space within this established field. Her…
View article: Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues
Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues Open
Synthesis of 6′-fluorinated carbauridine scaffolds enables access to related cytidine, ProTide and 2′-deoxy analogues, alongside preliminary exploration of their biological capabilities in cancer cell viability assays.
View article: Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues
Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues Open
Synthesis of 4-thioribose building blocks and related 4′-thio and 4′-sulfinyl nucleoside analogues.
View article: Synthesis and anticancer evaluation of 4’-thio and 4’-sulfinyl pyrimidine nucleoside analogues
Synthesis and anticancer evaluation of 4’-thio and 4’-sulfinyl pyrimidine nucleoside analogues Open
Analogues of the canonical nucleosides required for nucleic acid synthesis have a longstanding presence and proven capability within antiviral and anticancer research. Despite their success, newer generations of such analogues are required…
View article: Synthesis and anticancer evaluation of 4’-thio and 4’-sulfinyl pyrimidine nucleoside analogues
Synthesis and anticancer evaluation of 4’-thio and 4’-sulfinyl pyrimidine nucleoside analogues Open
Analogues of the canonical nucleosides required for nucleic acid synthesis have a longstanding presence and proven capability within antiviral and anticancer research. Despite their success, newer generations of such analogues are required…
View article: Hierarchical TiO<sub>2</sub> Nanoflower Photocatalysts with Remarkable Activity for Aqueous Methylene Blue Photo-Oxidation
Hierarchical TiO<sub>2</sub> Nanoflower Photocatalysts with Remarkable Activity for Aqueous Methylene Blue Photo-Oxidation Open
This study systematically evaluates the performance of a series of TiO2 nanoflower (TNF) photocatalysts for aqueous methylene blue photo-oxidation under UV irradiation. TNF nanoflowers were synthesized from Ti(IV) butoxide by a hydrotherma…
View article: Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues
Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues Open
Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. Ho…
View article: Thrombogenicity Testing for Blood-Contacting Medical Devices in an In Vitro Human Blood-Loop
Thrombogenicity Testing for Blood-Contacting Medical Devices in an In Vitro Human Blood-Loop Open
Thrombogenicity testing continues to be a critical requirement for regulatory approval of blood-contacting medical devices and the ISO guidelines have recently been updates [1]. This new guideline ascribes value to both in vivo and in vitr…
View article: Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody
Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody Open
Delivering potent, stable, targeted andin vivoefficacious antibody–drug conjugates (ADCs) using pyridazinedione functional disulfide re-bridging reagents.
View article: Use of a next generation maleimide in combination with THIOMAB™ antibody technology delivers a highly stable, potent and near homogeneous THIOMAB™ antibody-drug conjugate (TDC)
Use of a next generation maleimide in combination with THIOMAB™ antibody technology delivers a highly stable, potent and near homogeneous THIOMAB™ antibody-drug conjugate (TDC) Open
Conjugation of next generation maleimides to engineered cysteines in a THIOMAB™ antibody delivers a highly stable and potent THIOMAB™ antibody-drug conjugate.
View article: Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis
Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis Open
Dibromomaleimide (DBM) reagents are described which hydrolyse rapidly post-conjugation, representing an optimised platform for homogeneous and stable antibody conjugation.
View article: From crystalline to amorphous calcium pyrophosphates: A solid state Nuclear Magnetic Resonance perspective
From crystalline to amorphous calcium pyrophosphates: A solid state Nuclear Magnetic Resonance perspective Open
The general concept of NMR crystallography is applied to the detailed study of calcium pyrophosphates (CPP), whether hydrated or not, and whether crystalline or amorphous. CPP are a fundamental family of materials among osteoarticular path…
View article: Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)
Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC) Open
A next generation maleimide–ADC is shown to have excellent stability in blood serum, as well as high potency and selectivity in vitro.
View article: A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation Open
Site-specific ubiquitin cysteine mutants enable an elegant method for the linkage-specific conjugation of ubiquitins through dibromomaleimides and dibromopyrdazinediones.
View article: A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine
A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine Open
Thiol-stable albumin biologics are enabled by controlled, quantitative hydrolysis of maleimide–albumin conjugates, i.e. with no retro-Michael.