Mark E. Engel
YOU?
Author Swipe
View article: Prevalence of Group A Streptococcal Pharyngitis and Antibiotic Susceptibility in Paediatric Patients With Sore Throats in Gaborone, Botswana
Prevalence of Group A Streptococcal Pharyngitis and Antibiotic Susceptibility in Paediatric Patients With Sore Throats in Gaborone, Botswana Open
Background Group A β‐haemolytic Streptococcus, also known as Streptococcus pyogenes , commonly causes childhood pharyngitis and can lead to severe complications like acute rheumatic fever and rheumatic heart disease. Timely penicillin trea…
View article: It’s not just droplets: a systematic review and meta-analysis of the modes of transmission of Group A Streptococcus
It’s not just droplets: a systematic review and meta-analysis of the modes of transmission of Group A Streptococcus Open
Background The transmission of Group A Streptococcus (Strep A) through respiratory droplets has been considered the dominant mode of transmission to date; however, little is known about the relative contribution of other modes of transmiss…
View article: Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease
Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease Open
Objective Ficolin-3 is a crucial protein for the activation of the complement system. Previous work has indicated this protein may play a role in the pathogenesis of rheumatic heart disease (RHD), and it has been hypothesised that ficolin-…
View article: Assessing the evidence for antibiotic management of laboratory-confirmed Streptococcus A skin infections to prevent acute rheumatic fever and rheumatic heart disease: a systematic review
Assessing the evidence for antibiotic management of laboratory-confirmed Streptococcus A skin infections to prevent acute rheumatic fever and rheumatic heart disease: a systematic review Open
View article: Design and Implementation of the Oral Medicine South Africa Registry: Epidemiology of Oral Lesions at three tertiary academic facilities in the Western Cape, South Africa
Design and Implementation of the Oral Medicine South Africa Registry: Epidemiology of Oral Lesions at three tertiary academic facilities in the Western Cape, South Africa Open
Background There is a dearth of information on the epidemiology of oral lesions in South Africa. Knowledge of the characteristics and distribution of oral lesions in South Africa has many practical and research-related implications. Method…
View article: Prevalence of sudden unexpected death of infants and its subcategories in low- or middle-income countries: a systematic review protocol
Prevalence of sudden unexpected death of infants and its subcategories in low- or middle-income countries: a systematic review protocol Open
Introduction Infant mortality in low or middle-income countries (LoMICs) is still triple that of high-income countries (HICs), and the high mortality burden regions are also weighed down by a triple or quadruple burden of disease such as H…
View article: Mobile Phone Text Message Reminders to Improve Vaccination Uptake: A Systematic Review and Meta-Analysis
Mobile Phone Text Message Reminders to Improve Vaccination Uptake: A Systematic Review and Meta-Analysis Open
Introduction: Mobile phone text message reminders (MPTMRs) have been implemented globally to promote vaccination uptake and recall rates. This systematic review evaluated the effectiveness of MPTMRs on vaccination recall rates. Methods: We…
View article: A survey of antibiotic resistance patterns among Group A Streptococcus isolated from invasive and non-invasive infections in Cape Town, South Africa
A survey of antibiotic resistance patterns among Group A Streptococcus isolated from invasive and non-invasive infections in Cape Town, South Africa Open
View article: Presence of Group A streptococcus frequently assayed virulence genes in invasive disease: a systematic review and meta-analysis
Presence of Group A streptococcus frequently assayed virulence genes in invasive disease: a systematic review and meta-analysis Open
Introduction It is currently unclear what the role of Group A streptococcus (GAS) virulence factors (VFs) is in contributing to the invasive potential of GAS. This work investigated the evidence for the association of GAS VFs with invasive…
View article: The prevalence of pulmonary hypertension in post-tuberculosis and active tuberculosis populations: a systematic review and meta-analysis
The prevalence of pulmonary hypertension in post-tuberculosis and active tuberculosis populations: a systematic review and meta-analysis Open
Background: The prevalence of tuberculosis (TB)-associated pulmonary hypertension (PH) has not previously been quantified, resulting in an underappreciated burden of disease. We aimed to estimate the prevalence of PH in post-TB and active …
View article: Diagnostic Accuracy of Computer-Aided Detection During Active Case Finding for Pulmonary Tuberculosis in Africa: A Systematic Review and Meta-analysis
Diagnostic Accuracy of Computer-Aided Detection During Active Case Finding for Pulmonary Tuberculosis in Africa: A Systematic Review and Meta-analysis Open
Background Computer-aided detection (CAD) may be a useful screening tool for tuberculosis (TB). However, there are limited data about its utility in active case finding (ACF) in a community-based setting, and particularly in an HIV-endemic…
View article: Evaluating the utility of the Allplex STI Essential Assay to determine the occurrence of urogenital sexually transmitted infections among symptomatic and asymptomatic patients in Cape Town, South Africa
Evaluating the utility of the Allplex STI Essential Assay to determine the occurrence of urogenital sexually transmitted infections among symptomatic and asymptomatic patients in Cape Town, South Africa Open
Background Sexually transmitted infections are among the most commonly occurring infections globally, with countries in sub-Saharan Africa exhibiting disproportionately higher prevalence rates. Numerous reports indicate the need for accura…
View article: WHAT DO WE KNOW ABOUT NOISE IMPACTS ON BIRDS? A SYSTEMATIC REVIEWS FOCUSING ON ACOUSTIC METHODOLOGY
WHAT DO WE KNOW ABOUT NOISE IMPACTS ON BIRDS? A SYSTEMATIC REVIEWS FOCUSING ON ACOUSTIC METHODOLOGY Open
In recent years, several studies have shown how anthropogenic noise impacts wildlife.The methodologies used to quantify noise appear to influence data reliability and subsequent findings.Therefore, it is appropriate to review the robustnes…
View article: Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report
Research opportunities for the primary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report Open
Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) encompasses the timely diagnosis and adequate treatment of the superficial group A Streptococcus (GAS) infections pharyngitis and impetigo. GAS is the only…
View article: Diagnostic test accuracy of artificial intelligence in screening for referable diabetic retinopathy in real-world settings: A systematic review and meta-analysis
Diagnostic test accuracy of artificial intelligence in screening for referable diabetic retinopathy in real-world settings: A systematic review and meta-analysis Open
Retrospective studies on artificial intelligence (AI) in screening for diabetic retinopathy (DR) have shown promising results in addressing the mismatch between the capacity to implement DR screening and increasing DR incidence. This revie…
View article: Diagnostic test accuracy of artificial intelligence in screening for referable diabetic retinopathy in real-world settings: A systematic review and meta-analysis
Diagnostic test accuracy of artificial intelligence in screening for referable diabetic retinopathy in real-world settings: A systematic review and meta-analysis Open
Studies on artificial intelligence (AI) in screening for diabetic retinopathy (DR) have shown promising results in addressing the mismatch between the capacity to implement DR screening and the increasing DR incidence; however, most of the…
View article: Burden of disease and barriers to comprehensive care for rheumatic heart disease in South Africa: an updated systematic review protocol
Burden of disease and barriers to comprehensive care for rheumatic heart disease in South Africa: an updated systematic review protocol Open
Introduction Rheumatic heart disease (RHD) is responsible for a significant burden of cardiovascular morbidity and mortality, and remains the most common cause of acquired heart disease among children and young adults in low-income and mid…
View article: Serum Immune Responses to Group A Streptococcal Antigens following Pharyngeal Acquisitions among Children in Cape Town, South Africa
Serum Immune Responses to Group A Streptococcal Antigens following Pharyngeal Acquisitions among Children in Cape Town, South Africa Open
There is currently limited information regarding the human immune response to group A streptococcal throat infection. An understanding of the kinetics and specificity of antibody responses against a panel of Group A Streptococcus (GAS) ant…
View article: Prevalence of group A streptococcal carriage in school children from Cape Town: A cross- sectional study and systematic review
Prevalence of group A streptococcal carriage in school children from Cape Town: A cross- sectional study and systematic review Open
Background. Asymptomatic children can be a major reservoir of pharyngeal group A streptococcus (GAS). The role of GAS carriage causing subsequent infections resulting in the manifestation of clinical symptoms, or being associated w…
View article: ‘Listen to my heart’: Qualitative researchers and people living with rheumatic heart disease collaborate to direct future RHD research
‘Listen to my heart’: Qualitative researchers and people living with rheumatic heart disease collaborate to direct future RHD research Open
Background. Rheumatic heart disease (RHD) is a preventable chronic cardiac condition that causes over 350 000 deaths annually, largely in low and middle-income countries, as a direct result of structural inequalities and inadequate…
View article: The severe presentation and poor outcomes of rheumatic heart disease in Namibia: Lessons from the REMEDY study
The severe presentation and poor outcomes of rheumatic heart disease in Namibia: Lessons from the REMEDY study Open
Background. This paper reports the baseline characteristics and outcomes of 266 Namibian patients in the Global Registry of Rheumatic Heart Disease.Objective. To describe clinical findings and outcomes in a cohort of children and adults wi…
View article: American Heart Association's Children's Strategically Focused Research Network Experience
American Heart Association's Children's Strategically Focused Research Network Experience Open
The American Heart Association's Strategically Focused Children's Research Network started in July 2017 with 4 unique programs at Children's National Hospital in Washington, DC; Duke University in Durham, North Carolina; University of Utah…
View article: Antibiotic Management of Laboratory Confirmed Strep a Skin Infections to Prevent Acute Rheumatic Fever and Rheumatic Heart Disease: A Systematic Review
Antibiotic Management of Laboratory Confirmed Strep a Skin Infections to Prevent Acute Rheumatic Fever and Rheumatic Heart Disease: A Systematic Review Open
View article: Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†
Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study† Open
Background: The genetics of rheumatic heart disease (RHDGen) Network was developed to assist the discovery and validation of genetic variations and biomarkers of risk for rheumatic heart disease (RHD) in continental Africans, as a part of …
View article: International air travel-related control measures to contain the Covid-19 pandemic: A companion review to a Cochrane rapid review
International air travel-related control measures to contain the Covid-19 pandemic: A companion review to a Cochrane rapid review Open
View article: Global prevalence of mortality and LV recovery in women with PPCM – a systematic review and meta-analysis
Global prevalence of mortality and LV recovery in women with PPCM – a systematic review and meta-analysis Open
Introduction Peripartum cardiomyopathy (PPCM) remains a major contributor to maternal morbidity and mortality worldwide. The disease is associated with various complications mainly occurring early during its course. Reported adverse outcom…
View article: Standardization of Epidemiological Surveillance of Invasive Group A Streptococcal Infections
Standardization of Epidemiological Surveillance of Invasive Group A Streptococcal Infections Open
Invasive group A streptococcal (Strep A) infections occur when Streptococcus pyogenes, also known as beta-hemolytic group A Streptococcus, invades a normally sterile site in the body. This article provides guidelines for establishing surve…
View article: Standardization of Epidemiological Surveillance of Group A Streptococcal Impetigo
Standardization of Epidemiological Surveillance of Group A Streptococcal Impetigo Open
Impetigo is a highly contagious bacterial infection of the superficial layer of skin. Impetigo is caused by group A Streptococcus (Strep A) and Staphylococcus aureus, alone or in combination, with the former predominating in many tropical …
View article: Standardization of Epidemiological Surveillance of Group A Streptococcal Pharyngitis
Standardization of Epidemiological Surveillance of Group A Streptococcal Pharyngitis Open
Pharyngitis, more commonly known as sore throat, is caused by viral and/or bacterial infections. Group A Streptococcus (Strep A) is the most common bacterial cause of pharyngitis. Strep A pharyngitis is an acute, self-limiting disease but …
View article: A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis
A global perspective on the management and outcomes of peripartum cardiomyopathy: a systematic review and meta‐analysis Open
Aims Peripartum cardiomyopathy (PPCM) remains a major contributor to maternal morbidity and mortality worldwide. The disease is associated with various complications occurring mainly early during its course. Reported adverse outcomes inclu…