Marvin Reid
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View article: Hydroxyurea pharmacokinetics in children with sickle cell anemia across different global populations
Hydroxyurea pharmacokinetics in children with sickle cell anemia across different global populations Open
Hydroxyurea provides effective disease-modifying treatment for people with sickle cell anemia (SCA), especially when escalated to maximum tolerated dose (MTD), but has wide interpatient dosing variability due to pharmacokinetic (PK) differ…
View article: Aberrant One-Carbon Metabolism and Ancestral Genetics Underlie Edematous Severe Acute Malnutrition
Aberrant One-Carbon Metabolism and Ancestral Genetics Underlie Edematous Severe Acute Malnutrition Open
Severe acute malnutrition (SAM) contributes to the death of millions of children under age five annually. SAM is clinically classified as non-edematous SAM (NESAM) or the more severe edematous SAM (ESAM), which is more common in east-centr…
View article: The Differential Modulatory Effects of Potassium Supplementation on Blood Pressure, Vascular Reactivity, Glomerular Filtration Rates, and Oxidative Stress in Different Experimental Hypertensive Models
The Differential Modulatory Effects of Potassium Supplementation on Blood Pressure, Vascular Reactivity, Glomerular Filtration Rates, and Oxidative Stress in Different Experimental Hypertensive Models Open
High-sodium/low-potassium in the modern diet, potassium excretion, and sodium retention have all been implicated in hypertension. Objectives: This study investigated the differential effects of potassium (K⁺) supplementation on blood press…
View article: 0182 The Impact of Depression on Sleep Among High School Students in Jamaica
0182 The Impact of Depression on Sleep Among High School Students in Jamaica Open
Introduction Depression is associated with sleep disorders such as insomnia; reported to create a cycle that makes it difficult to get an adequate amount of sleep. As adolescents (ages 10-19) develop, adequate sleep is an important compone…
View article: 0267 Substance Use and Sleep Issues: Findings from an Internet Gaming Addiction Study on Jamaican Adolescents
0267 Substance Use and Sleep Issues: Findings from an Internet Gaming Addiction Study on Jamaican Adolescents Open
Introduction Addiction and sleep disorders are a problem due to its impact on sleep physiology. We evaluated substance use, gaming addiction, and sleep issues among adolescents. Methods Data are from a 3-stage stratified cluster-sample of …
View article: A Five‐Year Retrospective Analysis Comparing Morbidity and Mortality Outcomes of Previous Myomectomy Surgical Delivery, and Elective Repeat Caesarean Section
A Five‐Year Retrospective Analysis Comparing Morbidity and Mortality Outcomes of Previous Myomectomy Surgical Delivery, and Elective Repeat Caesarean Section Open
Objectives To determine the differences in maternal and neonatal morbidity between three groups of women, Group 1, women with a previous myomectomy, ( n = 69), Group 2, women who had an elective caesarean section ( n = 92), and Group 3, wo…
View article: The Prevalence of 5 Alpha Reductase Inhibitor Adverse Events in Patients with Benign Prostatic Hyperplasia in Jamaica
The Prevalence of 5 Alpha Reductase Inhibitor Adverse Events in Patients with Benign Prostatic Hyperplasia in Jamaica Open
Aim: To determine the prevalence of adverse effects (sexual dysfunction, depression and gynaecomastia) of 5-ARIs in patients with BPH in Jamaica. Study Design: A Prospective Cohort Study. Place and Duration of Study: Genitourinary Outpatie…
View article: Cannabis Use Patterns Among Adults Living With Chronic Pain Before and During the COVID Pandemic: Insights From the COVID‐19 Cannabis Health Study
Cannabis Use Patterns Among Adults Living With Chronic Pain Before and During the COVID Pandemic: Insights From the COVID‐19 Cannabis Health Study Open
Background This study aims to identify sociodemographic factors associated with cannabis use for chronic pain management before and after COVID‐19 was declared a pandemic. Furthermore, it seeks to compare cannabis use patterns in adults wi…
View article: Changing Contribution of Different Aetiologies of Maxillofacial Fractures - A Retrospective Study
Changing Contribution of Different Aetiologies of Maxillofacial Fractures - A Retrospective Study Open
Introduction: Maxillofacial fractures cost the New Zealand Accident Compensation Corporation approximately NZ$ 70–80 million annually. We have previously reported on ethnic and age groups disproportionately affected by these injuries and t…
View article: Maternal morbidity and mortality associated with mode of delivery in Sickle cell disease: an observational study
Maternal morbidity and mortality associated with mode of delivery in Sickle cell disease: an observational study Open
Objective: To compare pregnancy outcomes based on mode of delivery in women with homozygous sickle cell disease (HbSS) to women without (HbAA). Design and setting: Retrospective observational study was performed using delivery records of 4…
View article: University consortium to address public health priorities and research capacity building in the Caribbean
University consortium to address public health priorities and research capacity building in the Caribbean Open
The State University of New York (SUNY) – University of the West Indies (UWI) Health Research Consortium (HRC) was implemented in 2015 by the SUNY Global Health Institute (GHI) and the SUNY-UWI Center for Leadership and Sustainable Develop…
View article: The use of a modified rescue cervical cerclage in a diamniotic dichorionic twin pregnancy that had cervical dilatation
The use of a modified rescue cervical cerclage in a diamniotic dichorionic twin pregnancy that had cervical dilatation Open
Objective We describe the successful utilization of a modified rescue cerclage in a 32‐year‐old G4 P1213 woman of Afro‐Caribbean descent with a Diamniotic Dichorionic twin gestation who presented at 20 weeks and 2 days for a routine anomal…
View article: Prevalence and distribution of ampc beta-lactamase producing escherichia coli and klebsiella pneumoniae isolates obtained from urine samples at a tertiary care hospital in the caribbean
Prevalence and distribution of ampc beta-lactamase producing escherichia coli and klebsiella pneumoniae isolates obtained from urine samples at a tertiary care hospital in the caribbean Open
Introduction The aim of this study was to investigate the prevalence and distribution of AmpC beta-lactamases (BLs) in uropathogens ( E. coli and K. pneumoniae ) at the University Hospital of the West Indies Jamaica (UHWI). Method De-dupli…
View article: Hydroxycarbamide treatment reduces transcranial Doppler velocity in the absence of transfusion support in children with sickle cell anaemia, elevated transcranial Doppler velocity, and cerebral vasculopathy: the EXTEND trial
Hydroxycarbamide treatment reduces transcranial Doppler velocity in the absence of transfusion support in children with sickle cell anaemia, elevated transcranial Doppler velocity, and cerebral vasculopathy: the EXTEND trial Open
Summary EXpanding Treatment for Existing Neurological Disease (EXTEND) investigated whether hydroxycarbamide lowers transcranial Doppler (TCD) velocities in Jamaican children with sickle cell anaemia (SCA) and elevated TCD velocity with or…
View article: 684 Contribution of Pulmonary Diseases to COVID-19 Mortality in a Diverse Community of New York City
684 Contribution of Pulmonary Diseases to COVID-19 Mortality in a Diverse Community of New York City Open
Introduction New York City has been one of the largest epicenters of the COVID-19 pandemic. This provided a wealth of data to examine the characteristics of COVID-19 patients in this multi-ethnic city, while assessing the contributions of …
View article: The Moderating Effect of Physical Activity on the Relationship between Sleep and Emotional Distress and the Difference between Blacks and Whites: A Secondary Data Analysis Using the National Health Interview Survey from 2005–2015
The Moderating Effect of Physical Activity on the Relationship between Sleep and Emotional Distress and the Difference between Blacks and Whites: A Secondary Data Analysis Using the National Health Interview Survey from 2005–2015 Open
(1) Background: Unhealthy sleep durations (short and long sleep) are associated with emotional distress (ED). Minority populations, specifically Blacks, are more burdened with unhealthy sleep durations and ED. The ameliorative effect of ph…
View article: Contribution of pulmonary diseases to COVID-19 mortality in a diverse urban community of New York
Contribution of pulmonary diseases to COVID-19 mortality in a diverse urban community of New York Open
We examined the relative contribution of pulmonary diseases (chronic obstructive pulmonary disease, asthma and sleep apnea) to mortality risks associated with Coronavirus Disease (COVID-19) independent of other medical conditions, health r…
View article: Addressing psychological resilience during the coronavirus disease 2019 pandemic: a rapid review
Addressing psychological resilience during the coronavirus disease 2019 pandemic: a rapid review Open
Purpose of review The mental health toll on populations exposed to COVID-19 is alarming, and there is a need to address this with urgency. This current review provides insights on how individuals, communities, and specific populations, suc…
View article: A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease
A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease Open
Therapeutics which reduce the pathology in sickle cell syndromes are needed, particularly non-cytotoxic therapeutics. Fetal hemoglobin (HbF, α2γ2) is established as a major regulator of disease severity; increased HbF levels correlate with…
View article: A-228 Are Those Who Fail Performance Validity Measures High Utilizers of Healthcare?
A-228 Are Those Who Fail Performance Validity Measures High Utilizers of Healthcare? Open
Objective One study reported that suboptimal effort on performance validity tests (PVTs) is associated with higher healthcare utilization within a VA setting, defined as the number of Emergency Department visits and inpatient hospitalizati…
View article: Characterization of Head and Neck Squamous Cell Carcinoma From Jamaican Patients
Characterization of Head and Neck Squamous Cell Carcinoma From Jamaican Patients Open
HNSCC is the sixth most common cancer worldwide and the seventh most common in Jamaica. Mortality rates for HNSCC in the Caribbean are among the highest in the world. Despite this there is no information on the molecular characterization o…
View article: 1025 Sleep Patterns In Head Neck Cancer Patients During Radiotherapy
1025 Sleep Patterns In Head Neck Cancer Patients During Radiotherapy Open
Introduction Sleep disturbances are reported to be highly prevalent in head and neck cancer (HNC) patients, but no carefully assessed sleep data exists in patients with HNC undergoing concurrent chemoradiotherapy (CRT). Methods To objectiv…
View article: Jamaican Universities Aiding the Design of an Urban Public Space
Jamaican Universities Aiding the Design of an Urban Public Space Open
Many governments are actively seeking solutions to address the economic crises bedeviling their countries. University/college towns have proven to be successful models of opportunities for attracting investments for economic development wh…
View article: Edematous severe acute malnutrition is characterized by hypomethylation of DNA
Edematous severe acute malnutrition is characterized by hypomethylation of DNA Open
Edematous severe acute childhood malnutrition (edematous SAM or ESAM), which includes kwashiorkor, presents with more overt multi-organ dysfunction than non-edematous SAM (NESAM). Reduced concentrations and methyl-flux of methionine in 1-c…
View article: Use of a public park for physical activity in the Caribbean: evidence from a mixed methods study in Jamaica
Use of a public park for physical activity in the Caribbean: evidence from a mixed methods study in Jamaica Open
This is the first study to describe the usage of a public park for PA in Jamaica. The study elicited aspects of park use for PA in a major urban park in Jamaica from different vantage points by using direct systematic observation augmented…
View article: Transcranial Doppler velocity among Jamaican children with sickle cell anaemia: determining the significance of haematological values and nutrition
Transcranial Doppler velocity among Jamaican children with sickle cell anaemia: determining the significance of haematological values and nutrition Open
Summary This study investigated the association of nutritional and haematological variables with maximum time‐averaged mean velocity (TAMV) measured by transcranial Doppler (TCD) velocity and the agreement of classification between two pro…