Mark E. Wong
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View article: Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, <i>EGFR</i> –Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer
Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, <i>EGFR</i> –Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer Open
PURPOSE Epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors (TKIs) are standard first-line therapy for EGFR -mutant, metastatic non–small cell lung cancer (NSCLC); however, most patients experience disease progression. We …
View article: Review of management of primary oesophagogastric cancers in East Asian versus Western countries
Review of management of primary oesophagogastric cancers in East Asian versus Western countries Open
Oesophagogastric cancers are amongst the commonest cancers world-wide and this commentary explores the current state of curative management for primary oesophagogastric cancers and highlights the differences in treatment approaches between…
View article: International Expert-Based Consensus Definition, Staging Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Inter-Disciplinary Modified Delphi Study
International Expert-Based Consensus Definition, Staging Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Inter-Disciplinary Modified Delphi Study Open
Purpose Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 diagnostic/staging systems, the tr…
View article: Data from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Data from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding Open
Purpose: The ubiquitously expressed transmembrane glycoprotein CD47 delivers an anti-phagocytic (do not eat) signal by binding signal-regulatory protein α (SIRPα) on macrophages. CD47 is overexpressed in cancer cells and its expression is …
View article: Supplementary Figure 2: Representative Hematology Data from Non-Human Primates Dosed with TTI-621. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Supplementary Figure 2: Representative Hematology Data from Non-Human Primates Dosed with TTI-621. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding Open
This figure shows representative hematology data from non-human primates (cynomolgus monkeys) dosed with TTI-621.
View article: Supplementary Figure 1: Gating strategy and representative dot plots for flow cytometry-based phagocytosis assay. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Supplementary Figure 1: Gating strategy and representative dot plots for flow cytometry-based phagocytosis assay. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding Open
This figure shows our gating strategy and representative dot plots for our flow cytometry-based phagocytosis assay.
View article: Supplementary Tables from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Supplementary Tables from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding Open
These four supplementary tables summarize the following: Supplementary Table 1. TTI-621 binding to human tumor cell lines Supplementary Table 2. TTI-621 binding to human primary tumor samples Supplementary Table 3. TTI-621 binding to perip…
View article: Data from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Data from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding Open
Purpose: The ubiquitously expressed transmembrane glycoprotein CD47 delivers an anti-phagocytic (do not eat) signal by binding signal-regulatory protein α (SIRPα) on macrophages. CD47 is overexpressed in cancer cells and its expression is …
View article: Supplementary Figure 1: Gating strategy and representative dot plots for flow cytometry-based phagocytosis assay. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Supplementary Figure 1: Gating strategy and representative dot plots for flow cytometry-based phagocytosis assay. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding Open
This figure shows our gating strategy and representative dot plots for our flow cytometry-based phagocytosis assay.
View article: Supplementary Figure 2: Representative Hematology Data from Non-Human Primates Dosed with TTI-621. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
Supplementary Figure 2: Representative Hematology Data from Non-Human Primates Dosed with TTI-621. from TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding Open
This figure shows representative hematology data from non-human primates (cynomolgus monkeys) dosed with TTI-621.
View article: Haematological and nutritional prognostic biomarkers for patients receiving CROSS or FLOT
Haematological and nutritional prognostic biomarkers for patients receiving CROSS or FLOT Open
This demonstrates that a high inflammatory state represented by an NLR ≥2, both at baseline and sustained, is prognostic and predictive of response in patients receiving FLOT or CROSS. Baseline hypoalbuminaemia is predictive of poorer outc…
View article: Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps
Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps Open
Craniofacial defects require a treatment approach that provides both robust tissues to withstand the forces of mastication and high geometric fidelity that allows restoration of facial architecture. When the surrounding soft tissue is comp…
View article: Real-World Outcomes of FLOT versus CROSS Regimens for Patients with Oesophagogastric Cancers
Real-World Outcomes of FLOT versus CROSS Regimens for Patients with Oesophagogastric Cancers Open
Introduction: Treatment of oesophageal (OC), gastro-oesophageal junction (GOJ), and gastric cancer (GC) includes either neoadjuvant Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) for OC or GOJ or perioperative 5…
View article: A 0.49 mm2 CMOS Low-Power TVCO Achieving FoM of 190.36 dBc/Hz for 5G New Radio Application
A 0.49 mm2 CMOS Low-Power TVCO Achieving FoM of 190.36 dBc/Hz for 5G New Radio Application Open
This paper describes the implementation of low-power, low-phase-noise (PN), and robust startup tailless class-C voltage-controlled oscillator (TVCO) for 5G new radio (NR) technology. It features dual gate voltage control source biasing to …
View article: CCSDS 123.0-B-2 compression standard cross-validation and fuzzing
CCSDS 123.0-B-2 compression standard cross-validation and fuzzing Open
Session 3B-Blanes-CCSDS 123.0-B-2 compression standard cross-validation and fuzzing
View article: Custom 3D printed titanium reconstruction plate with in-situ tissue engineering for the reconstruction and dental rehabilitation of a severely infected atrophic mandible. A review of technique
Custom 3D printed titanium reconstruction plate with in-situ tissue engineering for the reconstruction and dental rehabilitation of a severely infected atrophic mandible. A review of technique Open
Purpose: This article aims to introduce the novel technique of utilization of a custom 3D titanium printed reconstruction combined with in-situ tissue engineering for the reconstruction and dental rehabilitation of an infected severely atr…
View article: Taking Serious Games Forward in Curriculum and Assessment
Taking Serious Games Forward in Curriculum and Assessment Open
Technology-driven educational modalities are increasingly utilized today in a variety of forms. Different combinations of the spectrum of simulation-based learning, the use of virtual reality, augmented reality, mixed reality, and serious …
View article: An Ovine Model of <i>In Vivo</i> Bioreactor-Based Bone Generation
An Ovine Model of <i>In Vivo</i> Bioreactor-Based Bone Generation Open
The generation of vascularized mineralized tissues of complex geometry without the use of extrinsic growth factors or exogenous cells requires a large animal model to recapitulate the challenges seen in the clinic. The proposed versatile o…
View article: A 2-stage Approach to Craniofacial Reconstruction in an Infected Ovine Mandibular Defect Model
A 2-stage Approach to Craniofacial Reconstruction in an Infected Ovine Mandibular Defect Model Open
INTRODUCTION: Reconstruction of infected mandibular defects is challenging due to the size and possible irregular shapes of defects, presence of pathogens, and the availability of suitable donor tissue. We have developed a 2-stage tissue e…
View article: Biomaterials-aided mandibular reconstruction using in vivo bioreactors
Biomaterials-aided mandibular reconstruction using in vivo bioreactors Open
Significance People may suffer large losses of mandibular (jaw) bone due to cancer, infection, trauma, congenital disease, or other disorders. The resulting bony defects are both aesthetically disfiguring and functionally disabling. We hav…
View article: Child and adolescent psychiatry in the Far East: A 5‐year follow up on the Consortium on Academic Child and Adolescent Psychiatry in the Far East (CACAP‐FE) study
Child and adolescent psychiatry in the Far East: A 5‐year follow up on the Consortium on Academic Child and Adolescent Psychiatry in the Far East (CACAP‐FE) study Open
Aim Data pertaining to child and adolescent psychiatry (CAP) training systems are limited as extant research has mostly been derived from one‐time data collection. This 5‐year follow‐up survey collects updated information on CAP training s…