Mark G. Luciano
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View article: Disproportionately Elevated Sulcal Index (DESI): An automatically driven index representing disproportionate subarachnoid space enlargement in brain MRI scans
Disproportionately Elevated Sulcal Index (DESI): An automatically driven index representing disproportionate subarachnoid space enlargement in brain MRI scans Open
Background Idiopathic normal pressure hydrocephalus (iNPH) is a reversible cause of dementia in older adults yet remains underdiagnosed due to nonspecific clinical presentation and reliance on invasive confirmatory tests. Conventional MRI …
View article: Fully Automated Deep Learning-Based Pipeline for Evans Index Measurement from Raw 3D MRI
Fully Automated Deep Learning-Based Pipeline for Evans Index Measurement from Raw 3D MRI Open
Ventriculomegaly is a key neuroimaging feature in conditions such as normal pressure hydrocephalus (NPH) and other disorders of cerebrospinal fluid (CSF) dynamics. The Evans Index (EI), defined as the ratio of the maximal frontal horn widt…
View article: A retrospective longitudinal analysis of risk factors, treatment outcomes and imaging parameters of ventricular collapse in idiopathic intracranial hypertension
A retrospective longitudinal analysis of risk factors, treatment outcomes and imaging parameters of ventricular collapse in idiopathic intracranial hypertension Open
View article: Step-up approach for severe acute necrotizing pancreatitis
Step-up approach for severe acute necrotizing pancreatitis Open
Severe acute pancreatitis accounts for 20% of cases, and pancreatic necrosis and infection significantly increase morbidity and mortality. The estimated mortality for infected necrosis without organ failure is around 1.4%, for necrosis wit…
View article: Middle Meningeal Artery Embolization in Chronic Subdural Hematoma in Post Shunted Normal Pressure Hydrocephalus
Middle Meningeal Artery Embolization in Chronic Subdural Hematoma in Post Shunted Normal Pressure Hydrocephalus Open
MMA-E in shunt-induced cSDHs has not shown increased resolution speed compared to SOC and liberal use of MMA-E on this cohort may need to be further investigated.
View article: Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM
Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM Open
Patients who have radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an obviously inva…
View article: Jugular venous narrowing and spontaneous spinal cerebrospinal fluid leaks: A case–control study exploring association and proposed mechanism
Jugular venous narrowing and spontaneous spinal cerebrospinal fluid leaks: A case–control study exploring association and proposed mechanism Open
Background Spontaneous skull base cerebrospinal fluid leaks (CSFLs) are associated with increased intracranial pressure in idiopathic intracranial hypertension (IIH) and hypothesized to relate to skull base erosions due to increased CSF pr…
View article: Bone Regrowth After Frontal Burr Hole Craniostomy: Natural History of 14-mm and 20-mm Burr Holes and Implications for Postoperative Trans-Burr Hole Ultrasound
Bone Regrowth After Frontal Burr Hole Craniostomy: Natural History of 14-mm and 20-mm Burr Holes and Implications for Postoperative Trans-Burr Hole Ultrasound Open
BACKGROUND AND OBJECTIVE: Burr hole craniostomy is performed for ventriculoperitoneal shunt insertion and endoscopic third ventriculostomy in patients with cerebrospinal fluid disorders. These burr holes are increasingly being used as wind…
View article: Molecular signatures of normal pressure hydrocephalus: a large-scale proteomic analysis of cerebrospinal fluid
Molecular signatures of normal pressure hydrocephalus: a large-scale proteomic analysis of cerebrospinal fluid Open
View article: Molecular Signatures of Normal Pressure Hydrocephalus: A Large-scale Proteomic Analysis of Cerebrospinal Fluid
Molecular Signatures of Normal Pressure Hydrocephalus: A Large-scale Proteomic Analysis of Cerebrospinal Fluid Open
Given the persistent challenge of differentiating idiopathic Normal Pressure Hydrocephalus (iNPH) from similar clinical entities, we conducted an in-depth proteomic study of cerebrospinal fluid (CSF) in 28 shunt-responsive iNPH patients, 3…
View article: Automated Ventricle Parcellation and Evan’s Ratio Computation in Pre- and Post-Surgical Ventriculomegaly
Automated Ventricle Parcellation and Evan’s Ratio Computation in Pre- and Post-Surgical Ventriculomegaly Open
Normal pressure hydrocephalus (NPH) is a brain disorder associated with enlarged ventricles and multiple cognitive and motor symptoms. The degree of ventricular enlargement can be measured using magnetic resonance images (MRIs) and charact…
View article: Optimal operating MR contrast for brain ventricle parcellation
Optimal operating MR contrast for brain ventricle parcellation Open
Development of MR harmonization has enabled different contrast MRIs to be synthesized while preserving the underlying anatomy. In this paper, we use image harmonization to explore the impact of different T1-w MR contrasts on a state-of-the…
View article: Investigation of probability maps in deep-learning-based brain ventricle parcellation
Investigation of probability maps in deep-learning-based brain ventricle parcellation Open
Normal Pressure Hydrocephalus (NPH) is a brain disorder associated with ventriculomegaly. Accurate segmentation of the ventricle system into its sub-compartments from magnetic resonance images (MRIs) could help evaluate NPH patients for su…
View article: Characteristics of shunt failure in 38,095 adult shunt insertion surgeries: a systematic review and meta-analysis
Characteristics of shunt failure in 38,095 adult shunt insertion surgeries: a systematic review and meta-analysis Open
OBJECTIVE The management of excess CSF in patients with hydrocephalus typically requires using a shunt to divert CSF. Unfortunately, there is a high rate of shunt failure despite improvements in device components and insertion techniques. …
View article: Combining physics‐based models with deep learning image synthesis and uncertainty in intraoperative cone‐beam CT of the brain
Combining physics‐based models with deep learning image synthesis and uncertainty in intraoperative cone‐beam CT of the brain Open
Background Image‐guided neurosurgery requires high localization and registration accuracy to enable effective treatment and avoid complications. However, accurate neuronavigation based on preoperative magnetic resonance (MR) or computed to…
View article: Automated Ventricle Parcellation and Evan's Ratio Computation in Pre- and Post-Surgical Ventriculomegaly
Automated Ventricle Parcellation and Evan's Ratio Computation in Pre- and Post-Surgical Ventriculomegaly Open
Normal pressure hydrocephalus~(NPH) is a brain disorder associated with enlarged ventricles and multiple cognitive and motor symptoms. The degree of ventricular enlargement can be measured using magnetic resonance images~(MRIs) and charact…
View article: Modifying the ICP pulse wave: effects on parenchymal blood flow pulsatility
Modifying the ICP pulse wave: effects on parenchymal blood flow pulsatility Open
This study demonstrated that external modification of ICP pulsatility, using a cardiac-gated inflatable device implanted epidurally in canines, alters brain tissue blood flow pulsatility. Specifically, decreasing systolic ICP increased blo…
View article: Placebo-Controlled Effectiveness of Idiopathic Normal Pressure Hydrocephalus Shunting: A Randomized Pilot Trial
Placebo-Controlled Effectiveness of Idiopathic Normal Pressure Hydrocephalus Shunting: A Randomized Pilot Trial Open
BACKGROUND: Multiple prospective nonrandomized studies have shown 60% to 70% of patients with idiopathic normal pressure hydrocephalus (iNPH) improve with shunt surgery, but multicenter placebo-controlled trial data are necessary to determ…
View article: First Experience With Postoperative Transcranial Ultrasound Through Sonolucent Burr Hole Covers in Adult Hydrocephalus Patients
First Experience With Postoperative Transcranial Ultrasound Through Sonolucent Burr Hole Covers in Adult Hydrocephalus Patients Open
BACKGROUND: Managing patients with hydrocephalus and cerebrospinal fluid (CSF) disorders requires repeated head imaging. In adults, it is typically computed tomography (CT) or less commonly magnetic resonance imaging (MRI). However, CT pos…
View article: Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain Open
Trigeminal neuralgia, historically dubbed the “suicide disease,” is an exceedingly painful neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, the only U.S. Food and Drug Administration (FDA)–approv…
View article: The Clinical Utility of the MOCA in iNPH Assessment
The Clinical Utility of the MOCA in iNPH Assessment Open
Objectives We sought to estimate reliable change thresholds for the Montreal Cognitive Assessment (MoCA) for older adults with suspected Idiopathic Normal Pressure Hydrocephalus (iNPH). Furthermore, we aimed to determine the likelihood tha…
View article: CSF Biomarkers Predict Gait Outcomes in Idiopathic Normal Pressure Hydrocephalus
CSF Biomarkers Predict Gait Outcomes in Idiopathic Normal Pressure Hydrocephalus Open
A combination of CSF biomarkers can predict improvement following shunt surgery for iNPH. However, these measures only modestly discriminate responders from nonresponders following CSF TT. The findings further suggest that abnormal CSF bio…
View article: Pre-Clinical Development of Robot-Assisted Ventriculoscopy for 3-D Image Reconstruction and Guidance of Deep Brain Neurosurgery
Pre-Clinical Development of Robot-Assisted Ventriculoscopy for 3-D Image Reconstruction and Guidance of Deep Brain Neurosurgery Open
Conventional neuro-navigation can be challenged in targeting deep brain structures via transventricular neuroendoscopy due to unresolved geometric error following soft-tissue deformation. Current robot-assisted endoscopy techniques are fai…
View article: P.208 Pilot Study of a Multi-center, Randomized, Blinded, Placebo-Controlled Trial of Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus
P.208 Pilot Study of a Multi-center, Randomized, Blinded, Placebo-Controlled Trial of Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus Open
Background: To describe preliminary results of a multi-center, randomized, blinded, placebo-controlled, pilot trial of shunt surgery in idiopathic normal pressure hydrocephalus (iNPH). Methods: Five sites of the Adult Hydrocephalus Clinica…
View article: Deformable 3D-2D registration for high-precision guidance and verification of neuroelectrode placement
Deformable 3D-2D registration for high-precision guidance and verification of neuroelectrode placement Open
Purpose. Accurate neuroelectrode placement is essential to effective monitoring or stimulation of neurosurgery targets. This work presents and evaluates a method that combines deep learning and model-based deformable 3D-2D registration to …
View article: Intraoperative cone‐beam and slot‐beam CT: 3D image quality and dose with a slot collimator on the O‐arm imaging system
Intraoperative cone‐beam and slot‐beam CT: 3D image quality and dose with a slot collimator on the O‐arm imaging system Open
Purpose To characterize the 3D imaging performance and radiation dose for a prototype slot‐beam configuration on an intraoperative O‐arm™ Surgical Imaging System (Medtronic Inc., Littleton, MA) and identify potential improvements in soft‐t…
View article: Using Uncertainty in Deep Learning Reconstruction for Cone-Beam CT of the Brain
Using Uncertainty in Deep Learning Reconstruction for Cone-Beam CT of the Brain Open
Contrast resolution beyond the limits of conventional cone-beam CT (CBCT) systems is essential to high-quality imaging of the brain. We present a deep learning reconstruction method (dubbed DL-Recon) that integrates physically principled r…
View article: Impact of international research fellows in neurosurgery: results from a single academic center
Impact of international research fellows in neurosurgery: results from a single academic center Open
OBJECTIVE International research fellows have been historically involved in academic neurosurgery in the United States (US). To date, the contribution of international research fellows has been underreported. Herein, the authors aimed to q…
View article: A proposed framework for cerebral venous congestion
A proposed framework for cerebral venous congestion Open
Background While venous congestion in the peripheral vasculature has been described and accepted, intracranial venous congestion remains poorly understood. The characteristics, pathophysiology, and management of cerebral venous stasis, ven…
View article: Functional connectivity abnormalities in Type I Chiari: associations with cognition and pain
Functional connectivity abnormalities in Type I Chiari: associations with cognition and pain Open
There is initial evidence of microstructural abnormalities in the fibre-tract pathways of the cerebellum and cerebrum of individuals diagnosed with Type I Chiari malformation. However, it is unclear whether abnormal white matter architectu…