Mark Gompels
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View article: Investigating pulmonary and non-infectious complications in common variable immunodeficiency disorders: a UK national multi-centre study
Investigating pulmonary and non-infectious complications in common variable immunodeficiency disorders: a UK national multi-centre study Open
Background Common Variable Immunodeficiency Disorders (CVID) encompass a spectrum of immunodeficiency characterised by recurrent infections and diverse non-infectious complications (NICs). This study aimed to describe the clinical features…
View article: Efficacy and Safety of Donidalorsen for Hereditary Angioedema
Efficacy and Safety of Donidalorsen for Hereditary Angioedema Open
Donidalorsen treatment reduced the hereditary angioedema attack rate, a finding that supports potential prophylactic use for hereditary angioedema. (Funded by Ionis Pharmaceuticals; OASIS-HAE ClinicalTrials.gov number, NCT05139810.).
View article: Prophylaxis in hereditary angioedema: a United Kingdom Delphi consensus
Prophylaxis in hereditary angioedema: a United Kingdom Delphi consensus Open
Hereditary angioedema (HAE) is a rare inherited disorder causing recurrent episodes of swelling that can be potentially life threatening. Treatment of HAE can be divided into on-demand treatment for swelling, and prophylaxis. The last UK c…
View article: Peripheral Neuropathy in Virologically Suppressed People Living with HIV: Evidence from the PIVOT Trial
Peripheral Neuropathy in Virologically Suppressed People Living with HIV: Evidence from the PIVOT Trial Open
The aim of this study is to identify the factors associated with peripheral neuropathy and to explore neurofilament light chain (NfL) as a biomarker for peripheral neuropathy (PN) in effectively virologically suppressed adults living with …
View article: Rate of response to initial antiretroviral therapy according to level of pre‐existing HIV‐1 drug resistance detected by next‐generation sequencing in the strategic timing of antiretroviral treatment (START) study
Rate of response to initial antiretroviral therapy according to level of pre‐existing HIV‐1 drug resistance detected by next‐generation sequencing in the strategic timing of antiretroviral treatment (START) study Open
Objectives The main objective of this analysis was to evaluate the impact of pre‐existing drug resistance by next‐generation sequencing (NGS) on the risk of treatment failure (TF) of first‐line regimens in participants enrolled in the STAR…
View article: Long-term effects on subclinical cardiovascular disease of switching from boosted protease inhibitors to dolutegravir
Long-term effects on subclinical cardiovascular disease of switching from boosted protease inhibitors to dolutegravir Open
Background In the NEAT022 trial, switching from boosted PIs (PI/r) to dolutegravir in people with HIV (PWH) with high cardiovascular risk decreased plasma lipids, soluble CD14 and adiponectin, and showed consistent favourable, although non…
View article: Hepmarc: A 96 week randomised controlled feasibility trial of add-on maraviroc in people with HIV and non-alcoholic fatty liver disease
Hepmarc: A 96 week randomised controlled feasibility trial of add-on maraviroc in people with HIV and non-alcoholic fatty liver disease Open
Objectives Maraviroc may reduce hepatic inflammation in people with HIV and non-alcoholic fatty liver disease (HIV-NAFLD) through CCR5-receptor antagonism, which warrants further exploration. Methods We performed an open-label 96-week rand…
View article: Chronic or recurrent Campylobacter enteritis in primary immunodeficiency: A UK national case-series and review of the literature
Chronic or recurrent Campylobacter enteritis in primary immunodeficiency: A UK national case-series and review of the literature Open
Clinical ImplicationsCampylobacter infection is an important diagnosis to consider in primary immunodeficiency patients with chronic or recurrent diarrhea, particularly in those with very low diagnostic immunoglobulin levels. Macrolides, a…
View article: Incidence of Hypertension and Blood Pressure Changes in Persons With Human Immunodeficiency Virus at High Risk for Cardiovascular Disease Switching From Boosted Protease Inhibitors to Dolutegravir: A Post-hoc Analysis of the 96-week Randomised NEAT-022 Trial
Incidence of Hypertension and Blood Pressure Changes in Persons With Human Immunodeficiency Virus at High Risk for Cardiovascular Disease Switching From Boosted Protease Inhibitors to Dolutegravir: A Post-hoc Analysis of the 96-week Randomised NEAT-022 Trial Open
Background Integrase inhibitors have been recently linked to a higher risk for hypertension. In NEAT022 randomized trial, virologically suppressed persons with human immunodeficiency virus (HIV, PWH) with high cardiovascular risk switched …
View article: Lanadelumab for the prevention of hereditary angioedema attacks: A real‐world <scp>UK</scp> audit
Lanadelumab for the prevention of hereditary angioedema attacks: A real‐world <span>UK</span> audit Open
Appendix S1: Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for …
View article: Limited Weight Impact After Switching From Boosted Protease Inhibitors to Dolutegravir in Persons With Human Immunodeficiency Virus With High Cardiovascular Risk: A Post Hoc Analysis of the 96-Week NEAT-022 Randomized Trial
Limited Weight Impact After Switching From Boosted Protease Inhibitors to Dolutegravir in Persons With Human Immunodeficiency Virus With High Cardiovascular Risk: A Post Hoc Analysis of the 96-Week NEAT-022 Randomized Trial Open
Background In the NEAT022 trial, virologically suppressed persons with human immunodeficiency virus (HIV) at high cardiovascular risk switching from protease inhibitors to dolutegravir either immediately (DTG-I) or after 48 weeks (DTG-D) s…
View article: Low circulating B cells in immunocompromised individuals are linked to poorer antibody responses to vaccines and a predisposition to viral infections
Low circulating B cells in immunocompromised individuals are linked to poorer antibody responses to vaccines and a predisposition to viral infections Open
Overall, there was a statistically significant association between low circulating B-cell counts and the incidence of clinically important viral infections in this patient cohort, even when controlling for relevant covariates. Clinicians c…
View article: Chronic Enteroviral Meningoencephalitis in a Patient with Good’s Syndrome Treated with Pocapavir
Chronic Enteroviral Meningoencephalitis in a Patient with Good’s Syndrome Treated with Pocapavir Open
To the Editor, Enteroviruses are a diverse selection of viruses which include polioviruses, coxsackieviruses, echoviruses, and others.Severe or persistent enteroviral infection is welldocumented in patients with antibody deficiency, mostly…
View article: The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update
The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update Open
Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up‐to‐date…
View article: Peripheral B Cell Deficiency and Predisposition to Viral Infections: The Paradigm of Immune Deficiencies
Peripheral B Cell Deficiency and Predisposition to Viral Infections: The Paradigm of Immune Deficiencies Open
In the era of COVID-19, understanding how our immune system responds to viral infections is more pertinent than ever. Immunodeficiencies with very low or absent B cells offer a valuable model to study the role of humoral immunity against t…
View article: Evidence of changing sexual behaviours and clinical attendance patterns, alongside increasing diagnoses of STIs in MSM and TPSM
Evidence of changing sexual behaviours and clinical attendance patterns, alongside increasing diagnoses of STIs in MSM and TPSM Open
Background Due to rising numbers of STI diagnosis and increasing prevalence of antimicrobial resistance, we explored trends in STI testing frequency and diagnoses, alongside sexual decision making and attitudes concerning condom use and HI…
View article: CNS demyelination associated with immune dysregulation and a novel <i>CTLA-4</i> variant
CNS demyelination associated with immune dysregulation and a novel <i>CTLA-4</i> variant Open
Background: The cytotoxic T-lymphocyte antigen-4 (CTLA-4) pathway acts as a negative immune regulator of T-cell activation and promotes self-tolerance. Case: We report the first case of biopsy-proven central nervous system inflammatory dem…
View article: A Family with a Novel CTLA4 Haploinsufficiency Mutation and Neurological Symptoms
A Family with a Novel CTLA4 Haploinsufficiency Mutation and Neurological Symptoms Open
To the Editor, CTLA4 haploinsufficiency is a rare autosomal dominant immune dysregulation disorder first described in 2014 [1,2].Patients with this disorder exhibit reduced expression of CTLA4, an inhibitory receptor that is found on activ…
View article: Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV
Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIV Open
Background Switching from boosted PIs to dolutegravir in people living with HIV (PLWH) with high cardiovascular risk improved plasma lipids at 48 weeks in the NEAT022 trial. Whether this strategy may have an impact on cardiovascular biomar…
View article: Transmitted HIV‐1 drug resistance in a large international cohort using next‐generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study
Transmitted HIV‐1 drug resistance in a large international cohort using next‐generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study Open
Objectives The aim of this analysis was to characterize transmitted drug resistance (TDR) in Strategic Timing of Antiretroviral Treatment (START) study participants by next‐generation sequencing (NGS), a sensitive assay capable of detectin…
View article: The wrong Spirochaete? Acute kidney injury in a returning traveller with syphilis – a case report
The wrong Spirochaete? Acute kidney injury in a returning traveller with syphilis – a case report Open
Background Syphilis has seen an increased incidence in recent years and can have serious and irreversible consequences if left un-diagnosed and untreated. This case report describes a presentation of syphilis and acute kidney injury – a sc…