Grant W. Hennig
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View article: Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels
Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels Open
Under healthy conditions the urinary bladder undergoes relatively long periods of filling with well‐spaced voiding events to ensure proper storage and removal of urine. During the filling phase distinct contractile events in the urinary bl…
View article: Endothelial Trauma Depends on Surface Charge and Extracellular Calcium Levels
Endothelial Trauma Depends on Surface Charge and Extracellular Calcium Levels Open
We tested the hypothesis that the ubiquitous store-operated Ca 2+ entry (SOCE) pathway contributes to histone-induced endothelial Ca 2+ events. We also considered an alternate hypothesis: cationic electrostatic interactions between histone…
View article: Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development
Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development Open
Background and aims Intestinal motility relies on inputs from multiple cells within a complex neuromuscular syncytium located in the gut wall. While it is known that motility is dependent on the development of motor patterns which govern c…
View article: Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels
Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels Open
Under healthy conditions the urinary bladder undergoes relatively long periods of filling with well-spaced voiding events to ensure proper storage and removal of urine respectively. During the filling phase, distinct contractile events in …
View article: Electrocalcium coupling in brain capillaries: Rapidly traveling electrical signals ignite local calcium signals
Electrocalcium coupling in brain capillaries: Rapidly traveling electrical signals ignite local calcium signals Open
The routing of blood flow throughout the brain vasculature is precisely controlled by mechanisms that serve to maintain a fine balance between local neuronal demands and vascular supply of nutrients. We recently identified two capillary en…
View article: Urothelium-derived prostanoids enhance contractility of urinary bladder smooth muscle and stimulate bladder afferent nerve activity in the mouse
Urothelium-derived prostanoids enhance contractility of urinary bladder smooth muscle and stimulate bladder afferent nerve activity in the mouse Open
This paper provides evidence for the role of urothelial-derived prostanoids in maintaining tone in the urinary bladder during bladder filling, not only underscoring the role of the urothelium as more than a barrier but also contributing to…
View article: Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature
Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature Open
The accumulation of the microtubule-associated tau protein in and around blood vessels contributes to brain microvascular dysfunction through mechanisms that are incompletely understood. Delivery of nutrients to active neurons in the brain…
View article: Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature
Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature Open
The accumulation of the microtubule-associated tau protein in and around blood vessels contributes to brain microvascular dysfunction through mechanisms that are incompletely understood. Delivery of nutrients to active neurons in the brain…
View article: Uncoupling of Ca <sup>2+</sup> sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia
Uncoupling of Ca <sup>2+</sup> sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia Open
The deficit in cerebral blood flow (CBF) seen in patients with hypertension-induced vascular dementia is increasingly viewed as a therapeutic target for disease-modifying therapy. Progress is limited, however, due to uncertainty surroundin…
View article: Quantifying whole bladder biomechanics using the novel pentaplanar reflected image macroscopy system
Quantifying whole bladder biomechanics using the novel pentaplanar reflected image macroscopy system Open
Optimal bladder compliance is essential to urinary bladder storage and voiding functions. Calculated as the change in filling volume per change in pressure, bladder compliance is used clinically to characterize changes in bladder wall biom…
View article: Quantifying Whole Bladder Biomechanics Using the Novel Pentaplanar Reflected Image Macroscopy System
Quantifying Whole Bladder Biomechanics Using the Novel Pentaplanar Reflected Image Macroscopy System Open
Optimal bladder compliance is essential to urinary bladder storage and voiding functions. Calculated as the change in filling volume per change in pressure, bladder compliance is used clinically to characterize changes in bladder wall biom…
View article: Afferent nerve activity in a mouse model increases with faster bladder filling rates in vitro, but voiding behavior remains unaltered in vivo
Afferent nerve activity in a mouse model increases with faster bladder filling rates in vitro, but voiding behavior remains unaltered in vivo Open
Storage and voiding functions in urinary bladder are well-known, yet fundamental physiological events coordinating these behaviors remain elusive. We sought to understand how voiding function is influenced by the rate at which the bladder …
View article: Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer’s disease
Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer’s disease Open
The brain microcirculation is increasingly viewed as a potential target for disease-modifying drugs in the treatment of Alzheimer’s disease patients, reflecting a growing appreciation of evidence that cerebral blood flow is compromised in …
View article: Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy
Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy Open
BACKGROUND Trauma patients with abnormal fibrinolysis have increased morbidity and mortality. Knowledge of mechanisms differentiating fibrinolytic phenotypes is important to optimize treatment. We hypothesized that subjects with abnormal f…
View article: Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis
Imatinib Mesylate Reduces Neurotrophic Factors and pERK and pAKT Expression in Urinary Bladder of Female Mice With Cyclophosphamide-Induced Cystitis Open
Imatinib mesylate is a tyrosine kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR)-α, -β, stem cell factor receptor (c-KIT), and BCR-ABL. PDGFRα is expressed in a subset of interstitial cells in the lamina propr…
View article: The Role of PIEZO1 in Urinary Bladder Function and Dysfunction in a Rodent Model of Cyclophosphamide-Induced Cystitis
The Role of PIEZO1 in Urinary Bladder Function and Dysfunction in a Rodent Model of Cyclophosphamide-Induced Cystitis Open
In the urinary bladder, mechanosensitive ion channels (MSCs) underlie the transduction of bladder stretch into sensory signals that are relayed to the PNS and CNS. PIEZO1 is a recently identified MSC that is Ca 2+ permeable and is widely e…
View article: Local IP <sub>3</sub> receptor–mediated Ca <sup>2+</sup> signals compound to direct blood flow in brain capillaries
Local IP <sub>3</sub> receptor–mediated Ca <sup>2+</sup> signals compound to direct blood flow in brain capillaries Open
Brain capillary calcium signaling controls blood flow.
View article: Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport
Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport Open
Significance The oviduct is essential for female fertility due to its two main functions: transport and nourishment. While the nourishment role is mainly fulfilled by secretory cells, the relative contribution to the transport function by …
View article: Prokinetic actions of luminally acting 5‐HT<sub>4</sub> receptor agonists
Prokinetic actions of luminally acting 5‐HT<sub>4</sub> receptor agonists Open
Background 5‐HT 4 receptor (5‐HT 4 R) agonists exert prokinetic actions in the GI tract, but non‐selective actions and potential for stimulation of non‐target 5‐HT 4 Rs have limited their use. Since 5‐HT 4 Rs are expressed in the colonic e…
View article: Actin is associated with tissue injury in trauma patients and produces a hypercoagulable profile in vitro
Actin is associated with tissue injury in trauma patients and produces a hypercoagulable profile in vitro Open
BACKGROUND While tissue injury provokes fibrinolysis shutdown in trauma, the mechanism remains elusive. Cellular death causes release of structural proteins, including actin and myosin, which may interact with clot formation and structure.…
View article: Decision letter: IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release
Decision letter: IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The ‘building-block’ model of inositol tri…
View article: Dense and dangerous: The tissue plasminogen activator-resistant fibrinolysis shutdown phenotype is due to abnormal fibrin polymerization
Dense and dangerous: The tissue plasminogen activator-resistant fibrinolysis shutdown phenotype is due to abnormal fibrin polymerization Open
BACKGROUND Both hyperfibrinolysis and fibrinolysis shutdown can occur after severe trauma. The subgroup of trauma patients with fibrinolysis shutdown resistant to tissue plasminogen activator (t-PA)-mediated fibrinolysis have increased mor…
View article: TRPV4 blockade reduces voiding frequency, ATP release, and pelvic sensitivity in mice with chronic urothelial overexpression of NGF
TRPV4 blockade reduces voiding frequency, ATP release, and pelvic sensitivity in mice with chronic urothelial overexpression of NGF Open
Transient receptor potential vanilloid family member 4 (TRPV4) transcript and protein expression increased in the urinary bladder and lumbosacral dorsal root ganglia of transgenic mice with chronic urothelial overexpression of nerve growth…
View article: BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus
BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus Open
Brain-derived neurotrophic factor (BDNF) is upregulated in the paraventricular nucleus of the hypothalamus (PVN) in response to hypertensive stimuli such as stress and hyperosmolality, and BDNF acting in the PVN plays a key role in elevati…
View article: Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility
Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility Open
Key points Electrical pacemaking in gastrointestinal muscles is generated by specialized interstitial cells of Cajal that produce the patterns of contractions required for peristalsis and segmentation in the gut. The calcium‐activated chlo…
View article: Motile cilia of the male reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence
Motile cilia of the male reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence Open
Cilia are cell-surface, microtubule-based organelles that project into extracellular space. Motile cilia are conserved throughout eukaryotes, and their beat induces the flow of fluid, relative to cell surfaces. In mammals, the coordinated …
View article: Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca<sup>2+</sup> Signaling In Situ
Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca<sup>2+</sup> Signaling In Situ Open
Ca2+ imaging of isolated cells or specific types of cells within intact tissues often reveals complex patterns of Ca2+ signaling. This activity requires careful and in-depth analyses and quantification to capture as much information about …