Mark Gruppetta
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View article: Changes in prevalence and incidence of pituitary neuroendocrine tumours: a 25-year population based study in malta
Changes in prevalence and incidence of pituitary neuroendocrine tumours: a 25-year population based study in malta Open
Objective: Epidemiological data is essential for assessing disease health burden. The aim of the study was to explore longitudinal trends in incidence and prevalence of pituitary neuroendocrine tumours (PitNET) and analyse these variations.
View article: Pituitary apoplexy: epidemiology, presentation and outcomes - a population-based study in malta
Pituitary apoplexy: epidemiology, presentation and outcomes - a population-based study in malta Open
Aims and Objectives: To determine the prevalence, incidence and outcomes of pituitary apoplexy patients presenting acutely in Malta.
View article: Incidence and survival of neuroendocrine neoplasia in the maltese islands - a population-based study
Incidence and survival of neuroendocrine neoplasia in the maltese islands - a population-based study Open
Introduction: The global incidence of neuroendocrine neoplasms (NENs) is increasing worldwide, however most studies are based on cancer-registry data, with different data collection methods, making it difficult for cross-country comparison…
View article: A study on incidence and related characteristics of PPGLs in a well-defined population
A study on incidence and related characteristics of PPGLs in a well-defined population Open
Phaeochromocytoma/paragangliomas (PPGLs) are relatively rare tumours and the health burden of such tumours is not very well known.
View article: Genetic characterization of pituitary neuroendocrine tumours in the maltese population
Genetic characterization of pituitary neuroendocrine tumours in the maltese population Open
Pituitary neuroendocrine tumours (PitNETs) have a prevalence of 75.7/100,000 within the Maltese population. These tumours present a wide range of clinical behaviours, from hormone overproduction to local effects secondary to compression of…
View article: How ready are endocrine scientists to share retrospective clinical data for research: a perspective from the European Network for the Study of Adrenal Tumors
How ready are endocrine scientists to share retrospective clinical data for research: a perspective from the European Network for the Study of Adrenal Tumors Open
Objective Individual patients' data sharing requires interoperability, security, ethical, and legal compliance. The aim was to assess the landscape and sharing capacities between endocrine researchers. Design A standardized survey (SurveyM…
View article: Epidemiological insights and survival patterns in neuroendocrine neoplasia: a geographic perspective
Epidemiological insights and survival patterns in neuroendocrine neoplasia: a geographic perspective Open
Neuroendocrine neoplasms, though rare, have shown marked increases in global incidence and prevalence over the past decade, as demonstrated by cancer registry data and studies from specialised tertiary centres. However, it remains unclear …
View article: Epidemiology, presentation and outcomes in pituitary apoplexy: a population-based study in Malta
Epidemiology, presentation and outcomes in pituitary apoplexy: a population-based study in Malta Open
Aims and objectives To determine the prevalence, incidence, and outcomes of pituitary apoplexy patients presenting acutely in Malta. Methodology Twenty-nine patients presenting with pituitary apoplexy between 1980 and 2023 were retrospecti…
View article: A retrospective evaluation of operated non-functional pituitary adenomas over four decades in the maltese population
A retrospective evaluation of operated non-functional pituitary adenomas over four decades in the maltese population Open
Introduction: Surgery in nonfunctional pituitary adenomas (NFPAs) is usually indicated when there is mass effect or progressive increase in size. Our study aims to analyze NFPAs which were operated until the end of 2023 in a well-defined p…
View article: High Population Frequency of <i>GNRHR</i> p.Q106R in Malta: An Evaluation of Fertility and Hormone Profiles in Heterozygotes
High Population Frequency of <i>GNRHR</i> p.Q106R in Malta: An Evaluation of Fertility and Hormone Profiles in Heterozygotes Open
Context The gonadotropin-releasing hormone receptor variant GNRHR p.Q106R (rs104893836) in homozygosity, compound heterozygosity, or single heterozygosity is often reported as the causative variant in idiopathic hypogonadotropic hypogonadi…
View article: Outcomes of Surgically treated Pituitary Adenomas in Malta - A Population-Based Study
Outcomes of Surgically treated Pituitary Adenomas in Malta - A Population-Based Study Open
Aim: The sequelae of surgically treated pituitary adenomas (PAs) is an important area of study to help guide management. Our study aims to analyse all PAs, functional and non-functional, which were operated until the end of 2022 in a well-…
View article: Inpatient hyperglycaemia, and impact on morbidity, mortality and re-hospitalisation rates
Inpatient hyperglycaemia, and impact on morbidity, mortality and re-hospitalisation rates Open
Hyperglycaemia is an important prognostic marker and may indicate a more severe illness. These patients should be highlighted for a greater level of care.
View article: Gender and age-matched case control study of a cohort of adrenal adenomas
Gender and age-matched case control study of a cohort of adrenal adenomas Open
Background: The majority of adrenal incidentalomas are benign and patients can be reassured, but a personalized and multidisciplinary approach is required when dealing with these lesions, since they might be linked with various comorbiditi…
View article: RNA profiling of human growth hormone-secreting and non-functioning pituitary adenomas reveals novel and differentially expressed immune related genes
RNA profiling of human growth hormone-secreting and non-functioning pituitary adenomas reveals novel and differentially expressed immune related genes Open
Pituitary neuroendocrine tumours (PitNETs) are broadly classified as non-functioning pituitary adenomas (NFPAs) and functional pituitary adenomas (FPAs) which include growth hormone secreting adenomas (GHPAs). Since the role of the immune …
View article: A novel population of activated cytotoxic T cells infiltrate pituitary neuroendocrine tumour subytpes
A novel population of activated cytotoxic T cells infiltrate pituitary neuroendocrine tumour subytpes Open
Non-functional pituitary adenomas (NFPA) are non-hormone secreting pituitary tumours while growth hormone-secreting pituitary adenomas (GHPA) are active pituitary tumours causing acromegaly. Since immunotherapy is becoming the preferred th…
View article: An analysis of blood parameter changes in cushing's syndrome - a population-based study
An analysis of blood parameter changes in cushing's syndrome - a population-based study Open
Aim: Glucocorticoids play a significant role in inflammation and immune system disruption. Our
\nstudy aimed to analyse different biochemical and blood count indices and serum inflammationbased
\nscores in patients with all different cause…
View article: Epidemiology and in-Depth Clinical and Biochemical Assessment of Cushing’s Syndrome – A Population-Based Study
Epidemiology and in-Depth Clinical and Biochemical Assessment of Cushing’s Syndrome – A Population-Based Study Open
Purpose: To provide complete epidemiological data on Cushing’s Syndrome (CS) with analysis and differentiation of biochemical parameters including blood count indices and serum inflammation-based scores. Methods: Clinical records of 35 pat…
View article: Biochemically silent phaeochromocytoma presenting with non-specific loin pain
Biochemically silent phaeochromocytoma presenting with non-specific loin pain Open
A 55-year-old woman presented with a 4-month history of right-sided non-specific loin pain and 6 kg weight loss. A CT scan of the abdomen and pelvis showed an incidental 4.5 cm right-sided adrenal lesion which was not typical of an adrenal…
View article: Hypercalcaemia due to ovarian small cell carcinoma of the hypercalcaemic type
Hypercalcaemia due to ovarian small cell carcinoma of the hypercalcaemic type Open
A 37-year-old woman presented with a few days’ history of lower abdominal pain and an incidental finding of hypercalcaemia. A thorough workup ensued, and the cause was found to be an exceptionally rare ovarian tumour—ovarian small cell car…
View article: Epidemiology of craniopharyngiomas: a population-based study in Malta
Epidemiology of craniopharyngiomas: a population-based study in Malta Open
Background Despite being benign tumours, craniopharyngiomas are challenging to manage and can cause significant morbidity and mortality in both the paediatric and adult population. The aim of the study was to analyse the epidemiology of cr…
View article: Ectopic ACTH secretion from a metastatic gastric carcinoma with neuroendocrine component
Ectopic ACTH secretion from a metastatic gastric carcinoma with neuroendocrine component Open
An elderly gentleman was admitted to hospital with severe hypokalaemia of 1.75mmol/L. A background of a recently diagnosed metastatic gastric carcinoma with a neuroendocrine component pointed towards the diagnosis of ectopic ACTH secretion…
View article: Cotrimoxazole-induced hyperkalaemia in a patient with known hypoaldosteronism
Cotrimoxazole-induced hyperkalaemia in a patient with known hypoaldosteronism Open
A70-year-old man, with established hypoadrenalism due to a previous bilateral adrenalectomy, was admitted with recurrent episodes of postural dizziness and presyncope. He had been discharged from hospital 3 weeks earlier on a 1-month cours…
View article: Sodium-glucose co-transporter 2 (SGLT2) inhibitors
Sodium-glucose co-transporter 2 (SGLT2) inhibitors Open
Type 2 diabetes mellitus is a progressive metabolic disorder. Marked hyperglycaemia leads to serious vascular complications. Hence, addressing this modifiable risk factor is of paramount importance. Sodium-glucose co-transporter 2 (SGLT2) …
View article: Functional ectopic adrenocortical carcinoma; A case report
Functional ectopic adrenocortical carcinoma; A case report Open
BACKGROUND: Adrenocortical carcinomas (ACC) are rare malignant tumours, with a quoted incidence of 0.7–2.0 cases/million habitants/year, with ectopic ACC being exceptionally rate. Diagnosis is based on clinical and biological assessment su…
View article: Radiological and functional analysis of a cohort of adrenal adenomas
Radiological and functional analysis of a cohort of adrenal adenomas Open
AIM: A cohort of adrenal incidentalomas which had radiological or histological characteristics in keeping with an adrenal adenoma was analysed in terms of the radiological and functional characteristics.
View article: An analysis of incidence and characteristics of cushing’s syndrome in malta: A population based study
An analysis of incidence and characteristics of cushing’s syndrome in malta: A population based study Open
AIM: There are few reports discussing incidence and characteristics of the whole group of Cushing’s syndrome patients in the literature. The aim was to establish the incidence of endogenous Cushing’s syndrome with in-depth analysis of thei…
View article: An analysis of craniopharyngioma patients in malta: Epidemiology, patient characterisation and long-term sequelae
An analysis of craniopharyngioma patients in malta: Epidemiology, patient characterisation and long-term sequelae Open
BACKGROUND: Despite being benign, craniopharyngiomas are challenging tumours to manage and can cause significant morbidity and mortality in both the paediatric and adult population.
View article: Isolated second-phase diabetes insipidus post-transsphenoidal surgery
Isolated second-phase diabetes insipidus post-transsphenoidal surgery Open
A 57-year-old woman presented with severe lethargy, dizziness and nausea 1 week after transsphenoidal resection of a growth hormone secreting pituitary adenoma. She was found to have severe hyponatremia of 115 mmol/L. Importantly, she was …
View article: Presentation and management of diabetic ketoacidosis in adults in Malta
Presentation and management of diabetic ketoacidosis in adults in Malta Open
Aim: The aim of this audit was to assess adherence to local guideline in the management of Diabetic Ketoacidosis (DKA).
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\nMethod: Patients admitted with DKA between April 2013 and March 2015 were identified and data was retrospective…