Explanipedia

Diffuse midline glioma with extra central nervous system metastases in the pediatric, adolescent, and young adult population Open

Alexandra Giantini-Larsen, Andrew Garton, Maricruz Rivera, Rachael Han, David J. Pisapia , et al. · 2025

Perspectives and Challenges of Multidisciplinary Collaboration in the Treatment of Metastatic Spinal Disease: Insights from an International Survey Open

Jantijn J G J Amelink, B Münster, Olivier Q. Groot, Britt B.M. Suelmann, Philip J. Saylor , et al. · 2025

Background Advances in systemic therapies, radiotherapy, and surgery have made the management of metastatic spinal disease more complex, increasing the need for multidisciplinary collaboration. This study aims to explore clinicians’ perspe…

Integration of Next Generation Sequencing Data to Inform Survival Prediction of Patients with Spine Metastasis Open

Alexandra Giantini-Larsen, Alexander Ramos, Axel Martin, Katherine S. Panageas, Caroline E. Kostrzewa , et al. · 2025

Background/Objectives: Spinal metastatic disease is a life-altering problem for individuals with cancer. Prognostication is key for tailored treatment of spinal metastases. This manuscript provides a comprehensive overview of the genomic p…

Introduction. Advances in spine tumor management: innovations in surgery, radiation, and biomarkers Open

Mark H. Bilsky, Fábio Ynoe de Moraes, C. Rory Goodwin, Daniel Lubelski, Michelle J. Clarke · 2025

Napsin A as a key prognostic biomarker in spinal metastases of lung cancer: implications for survival and neurological function Open

Albert Antar, Abdel‐Hameed Al‐Mistarehi, A. Daniel Davidar, Yuanxuan Xia, Pritika Papali , et al. · 2025

OBJECTIVE Lung cancer’s propensity for metastasizing to the spine significantly impacts morbidity and mortality. Understanding the impact of somatic mutations on the prognosis of these metastases is crucial for treatment development and op…

Neurological decline due to a vascular etiology in patients with spine tumors: a patient series and cautionary tale Open

Scott L. Zuckerman, Hani Chanbour, Harsh Jain, Alexandra Giantini-Larsen, Jacob P. Schwarz , et al. · 2025

OBJECTIVE Patients harboring spine tumors may experience neurological decline due to vascular etiology, such as hypoperfusion or vascular steal. Spinal cord ischemia or stroke in the setting of spine tumors is a rarely reported but potenti…

Impact of surgery and radiation on radicular pain and myotomic weakness in patients with metastatic spine disease Open

Arthur R. Bartolozzi, Ori Barzilai, Ilya Laufer, Arjun Sahgal, Laurence D. Rhines , et al. · 2025

OBJECTIVE Surgery is typically indicated for mechanical pain in metastatic spine disease or severe neurological compromise, but how radicular pain responds to oncological treatment is not well described. The primary aim of this study was t…

Modeling lung adenocarcinoma metastases using patient-derived organoids Open

Yuan Liu, Manendra B. Lankadasari, Joel Rosiene, Kevin B. Johnson, Juan Zhou , et al. · 2024

Approximately 50% of patients with surgically resected early-stage lung cancer develop distant metastasis. At present, there is no in vivo metastasis model to investigate the biology of human lung cancer metastases. Using well-characterize…

Safety and Efficacy of Surgical Implantation of Intrathecal Drug Delivery Pumps in Patients With Cancer With Refractory Pain Open

Graham Winston, Jeffrey Zimering, Christopher Newman, Anne S. Reiner, Noel Manalil , et al. · 2024

BACKGROUND AND OBJECTIVES: Pain management in patients with cancer is a critical issue in oncology palliative care as clinicians aim to enhance quality of life and mitigate suffering. Most patients with cancer experience cancer-related pai…

Separation surgery for metastatic spine tumors: How less became more Open

Xiaoran Zhang, Alexandra Giantini-Larsen, Natasha Kharas, Mark H. Bilsky, W. Christopher Newman · 2024

Metastatic epidural spinal cord compression (MESCC) is an increasingly common clinical entity in cancer patients and is associated with significant morbidity and neurologic sequalae. Management of MESCC has undergone many significant parad…

<i>GRM1</i>-Rearranged Chondromyxoid Fibroma With FGF23 Expression: A Potential Pitfall in Small Biopsies Open

Isidro Machado, Yanming Zhang, Meera Hameed, Sinchun Hwang, Aarti E. Sharma , et al. · 2024

The clinical, radiological, and histopathological features of chondromyxoid fibroma can sometimes resemble those of other benign or malignant tumors. Recently, recurrent GRM1 rearrangements have been identified in chondromyxoid fibroma, an…

Introduction. Intradural spine tumor surgery Open

Michelle J. Clarke, Paul C. McCormick, Mark H. Bilsky, Praveen V. Mummaneni · 2023

INTRODUCTIONIntradural spine tumors pose unique challenges to neurosurgeons because of their delicate location within or adjacent to the spinal cord and surrounding neural structures. The evolving field of intradural surgery has witnessed …

The Role of En Bloc Resection in the Modern Era for Primary Spine Tumors Open

Caleb M. Yeung, Mark H. Bilsky, Patrick J. Boland, Max Vaynrub · 2023

Study Design. A literature review. Objective. The aim of this review is to provide an overview of benign and malignant primary spine tumors and a balanced analysis of the benefits and limitations of (and alternatives to) surgical treatment…

Superior sulcus non–small cell lung cancers (Pancoast tumors): Current outcomes after multidisciplinary management Open

Kaitlin McLaughlin, Kay See Tan, Joseph Dycoco, Monica F. Chen, Jamie E. Chaft , et al. · 2023

El enfoque de NOMS para los tumores metastásicos: integración de nuevas tecnologías para mejorar los resultados Open

W. Christopher Newman, Alexander Larsen, Mark H. Bilsky · 2023

Treatment paradigms for patients with spine metastases have evolved significantly over the past two decades. The most transformative change to these paradigms has been the integration of spinal stereotactic radiosurgery (sSRS). sSRS allows…

The NOMS approach to metastatic tumors: Integrating new technologies to improve outcomes Open

W. Christopher Newman, Alexandra Giantini-Larsen, Mark H. Bilsky · 2023

Treatment paradigms for patients with spine metastases have evolved significantly over the past two decades. The most transformative change to these paradigms has been the integration of spinal stereotactic radiosurgery (sSRS). sSRS allows…

Radiotherapy for Mobile Spine and Sacral Chordoma: A Critical Review and Practical Guide from the Spine Tumor Academy Open

Kristin J. Redmond, Stephanie K. Schaub, Sheng-Fu Larry Lo, Majid Khan, Daniel Lubelski , et al. · 2023

Chordomas are rare tumors of the embryologic spinal cord remnant. They are locally aggressive and typically managed with surgery and either adjuvant or neoadjuvant radiation therapy. However, there is great variability in practice patterns…

Preoperative Embolization of Metastatic Spinal Cord Compression with n-Butyl Cyanoacrylate: Safety and Effectiveness in Limiting Blood Loss Open

Eslam Youssef, Ernesto Santos, Amgad M. Moussa, Eric Lis, Max Vaynrub , et al. · 2023

The Impact of Targetable Mutations on Clinical Outcomes of Metastatic Epidural Spinal Cord Compression in Patients With Non–Small-Cell Lung Cancer Treated With Hybrid Therapy (Surgery Followed by Stereotactic Body Radiation Therapy) Open

Vikram Chakravarthy, Benjamin Schachner, Anubhav G. Amin, Anne S. Reiner, Yoshiya Yamada , et al. · 2022

BACKGROUND: In treatment of metastatic epidural spinal cord compression (MESCC), hybrid therapy, consisting of separation surgery, followed by stereotactic body radiation therapy, has become the mainstay of treatment for radioresistant pat…

Long-Term Clinical Outcomes of Patients with Colorectal Cancer with Metastatic Epidural Spinal Cord Compression Treated with Hybrid Therapy (Surgery Followed by Stereotactic Body Radiation Therapy) Open

Vikram Chakravarthy, Benjamin Schachner, Anubhav G. Amin, Anne S. Reiner, Yoshiya Yamada , et al. · 2022

Patient outcomes following implementation of an enhanced recovery after surgery pathway for patients with metastatic spine tumors Open

Vikram Chakravarthy, Ilya Laufer, Anubhav G. Amin, Marc A. Cohen, Anne S. Reiner , et al. · 2022

Background Metastatic spine tumor surgery consists of palliative operations performed on frail patients with multiple medical comorbidities. Enhanced recovery after surgery (ERAS) programs involve an evidence‐based, multidisciplinary appro…

Fifty‐year history of the evolution of spinal metastatic disease management Open

W. Christopher Newman, Mark H. Bilsky · 2022

Spine metastases are a significant source of morbidity in oncology. Treatment of these spine metastases largely remains palliative, but advances over the past 50 years have improved the effectiveness of interventions for preserving functio…

Responder Analysis of Pain Relief After Surgery for the Treatment of Spinal Metastatic Tumors Open

Robert J. Rothrock, Anne S. Reiner, Ori Barzilai, Nora C. Kim, Shahiba Ogilvie , et al. · 2022

BACKGROUND: Central tendency analysis studies demonstrate that surgery provides pain relief in spinal metastatic tumors. However, they preclude patient-specific probability of treatment outcome. OBJECTIVE: To use responder analysis to stud…

Efficacy of an Esophageal Spacer for Spine Radiosurgery: First Experience Open

Thomas Boerner, Chunzi Jenny Jin, Caitlin Harrington, Mark H. Bilsky, Yoshiya Yamada , et al. · 2022

Dosimetric Effect of Cobalt-Chrome Stabilization Hardware in Paraspinal Radiation Treatments Open

Grace Tang, T LoSasso, Seng Boh Lim, Yoshiya Yamada, Mark H. Bilsky , et al. · 2022

High density materials are assigned with an apparent density of 3.2 g/cm3 in 12-bit CT images due to saturation. This is often ignored in planning for spine tumors with titanium (density 4.40 g/cm3) spinal hardware. However, new cobalt-chr…

Surgery for Metastatic Spinal Disease in Octogenarians and Above: Analysis of 78 Patients Open

Ibrahim Hussain, Benjamin Hartley, Lily McLaughlin, Anne S. Reiner, Ilya Laufer , et al. · 2021

Study Design: Retrospective Cohort Study. Objective: Octogenarians living with spinal metastases are a challenging population to treat. Our objective was to identify the rate, types, management, and predictors of complications and survival…

CT-Based Image-Guided Navigation and the DaVinci Robot in Spine Oncology: Changing Surgical Paradigms Open

Anubhav G. Amin, Ori Barzilai, Mark H. Bilsky · 2021

Editorial. Multiple myeloma presenting as an unknown primary disease: to operate or not to operate, that is the question Open

Mark H. Bilsky, Ori Barzilai · 2021

Introduction. Treatment of spinal cord and spinal axial tumors Open

Mark H. Bilsky, Ziya L. Gokaslan, John H. Shin, Nicolas Dea, Fábio Ynoe de Moraes · 2021

Short-segment cement-augmented fixation in open separation surgery of metastatic epidural spinal cord compression: initial experience Open

W. Christopher Newman, Anubhav G. Amin, Jemma Villavieja, Ilya Laufer, Mark H. Bilsky , et al. · 2021

OBJECTIVE High-grade metastatic epidural spinal cord compression from radioresistant tumor histologies is often treated with separation surgery and adjuvant stereotactic body radiation therapy. Historically, long-segment fixation is perfor…

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