Mark H. Edwards
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View article: Characterising the clinical associations of hallucinogen persisting perceptual disorder: a retrospective cohort study
Characterising the clinical associations of hallucinogen persisting perceptual disorder: a retrospective cohort study Open
Hallucinogen persisting perceptual disorder (HPPD) is characterised by episodes of altered perception linked to past psychoactive drug use, accompanied by distress and functional impairment. To date, clinical characterisation has been limi…
View article: An aortic root abscess mimic identified by multi-disciplinary imaging review: a case report
An aortic root abscess mimic identified by multi-disciplinary imaging review: a case report Open
Background While echocardiography and cardiac positron emission tomography (PET) can aid in the diagnosis of prosthetic valve endocarditis (PVE), post-operative changes can lead to false-positive imaging findings. We report a case of a pat…
View article: Neuropsychiatric and Mental Health Outcomes in Hyperemesis Gravidarum: A Retrospective Cohort Study
Neuropsychiatric and Mental Health Outcomes in Hyperemesis Gravidarum: A Retrospective Cohort Study Open
View article: Relationships Between Muscle Parameters and History of Falls and Fractures in the Hertfordshire Cohort Study: Do All Muscle Components Relate Equally to Clinical Outcomes?
Relationships Between Muscle Parameters and History of Falls and Fractures in the Hertfordshire Cohort Study: Do All Muscle Components Relate Equally to Clinical Outcomes? Open
In previous work, relationships between muscle and bone size and strength have been demonstrated and were stronger in females, suggesting possible sexual dimorphism. Here we examine sex-specific associations between individual muscle sarco…
View article: Neighborhood environment, social participation, and physical activity in older adults with lower limb osteoarthritis: A mediation analysis
Neighborhood environment, social participation, and physical activity in older adults with lower limb osteoarthritis: A mediation analysis Open
View article: Poor sleep quality and physical performance in older adults
Poor sleep quality and physical performance in older adults Open
View article: Factors Associated With Functional Decline in Hand and Hip/Knee Osteoarthritis After One Year: Data From a Population‐Based Study
Factors Associated With Functional Decline in Hand and Hip/Knee Osteoarthritis After One Year: Data From a Population‐Based Study Open
Objective To investigate factors that together with hand or hip/knee osteoarthritis (OA) could contribute to functional decline over a year’s time in elderly individuals. Methods The data of 1,886 individuals between ages 65 and 85 years i…
View article: Bone Health in Rheumatoid Arthritis: What Can Studies of Bone Microarchitecture Tell Us?
Bone Health in Rheumatoid Arthritis: What Can Studies of Bone Microarchitecture Tell Us? Open
Introduction: Rheumatoid arthritis (RA) is associated with changes in skeletal health, including increased risk of fracture. This study used a novel technique, high-resolution quantitative CT (HRpQCT), to assess bone microarchitecture in p…
View article: Are jumping mechanography assessed muscle force and power, and traditional physical capability measures associated with falls in older adults? Results from the Hertfordshire Cohort Study.
Are jumping mechanography assessed muscle force and power, and traditional physical capability measures associated with falls in older adults? Results from the Hertfordshire Cohort Study. Open
Jumping mechanography-measured muscle power and velocity were associated with lower risk of falls. In this relatively healthy cohort of older adults JM appears to be more sensitive measure of muscle deficits and falls risk than standard PC…
View article: P129 Adolescent knee pain and risk of knee osteoarthritis 50 years later
P129 Adolescent knee pain and risk of knee osteoarthritis 50 years later Open
Background Adolescent knee pain is a common complaint which may be due to patellar dislocation, meniscal tear, Osgood-Schlatter’s disease or patellofemoral maltracking. We studied the association of such pain with knee osteoarthritis (OA) …
View article: Clinical osteoarthritis of the hip and knee and fall risk: The role of low physical functioning and pain medication
Clinical osteoarthritis of the hip and knee and fall risk: The role of low physical functioning and pain medication Open
View article: Association Between Osteoarthritis and Social Isolation: Data From the EPOSA Study
Association Between Osteoarthritis and Social Isolation: Data From the EPOSA Study Open
OBJECTIVE To determine whether there is an association between osteoarthritis (OA) and incident social isolation using data from the European Project on OSteoArthritis (EPOSA) study. DESIGN Prospective, observational study with 12 to 18 mo…
View article: Cluster Analysis of Finite Element Analysis and Bone Microarchitectural Parameters Identifies Phenotypes with High Fracture Risk
Cluster Analysis of Finite Element Analysis and Bone Microarchitectural Parameters Identifies Phenotypes with High Fracture Risk Open
High-resolution peripheral quantitative computed tomography (HRpQCT) is increasingly used for exploring associations between bone microarchitectural and finite element analysis (FEA) parameters and fracture. We hypothesised that combining …
View article: Minimal clinically important decline in physical function over one year: EPOSA study
Minimal clinically important decline in physical function over one year: EPOSA study Open
The most reliable MCID estimates of decline over 1 year in the AUSCAN hand and WOMAC hip/knee physical function scores were 4 and 2 points, respectively.
View article: A diagnosis of knee osteoarthritis does not predict physical activity 2 years later in older adults: findings from the Hertfordshire Cohort Study
A diagnosis of knee osteoarthritis does not predict physical activity 2 years later in older adults: findings from the Hertfordshire Cohort Study Open
Osteoarthritis (OA) can negatively impact levels of physical activity (PA), although current clinical advice promotes the benefits of staying active in preventing joint degeneration. In this study, we examine how knee OA, assessed by self-…
View article: Impact of osteoarthritis on activities of daily living: does joint site matter?
Impact of osteoarthritis on activities of daily living: does joint site matter? Open
View article: Within-person pain variability and physical activity in older adults with osteoarthritis from six European countries
Within-person pain variability and physical activity in older adults with osteoarthritis from six European countries Open
View article: Impact du traitement par statines dans la progression radiologique de la gonarthrose : résultats issus de l’analyse post-hoc de l’essai SEKOIA
Impact du traitement par statines dans la progression radiologique de la gonarthrose : résultats issus de l’analyse post-hoc de l’essai SEKOIA Open
View article: Diet Quality and Bone Measurements Using HRpQCT and pQCT in Older Community-Dwelling Adults from the Hertfordshire Cohort Study
Diet Quality and Bone Measurements Using HRpQCT and pQCT in Older Community-Dwelling Adults from the Hertfordshire Cohort Study Open
There are few data describing associations between dietary patterns and bone microarchitecture. This study investigated the relationship between diet quality and HRpQCT and pQCT measures in older adults. Data were available for 184 men and…
View article: Longitudinal Change in Peripheral Quantitative Computed Tomography Assessment in Older Adults: The Hertfordshire Cohort Study
Longitudinal Change in Peripheral Quantitative Computed Tomography Assessment in Older Adults: The Hertfordshire Cohort Study Open
View article: Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss
Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss Open
Objective Osteoarthritis‐related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change Index ( RCI ) determines whether the magnitude of change observed in an individual can be attr…
View article: Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire cohort study
Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire cohort study Open
View article: 092 Physical performance is associated with self-reported and clinical osteoarthritis, but not radiographic osteoarthritis in both sexes
092 Physical performance is associated with self-reported and clinical osteoarthritis, but not radiographic osteoarthritis in both sexes Open
View article: 090 DNA methylation and its relationship with musculoskeletal health in older adults from the Hertfordshire Cohort Study: findings from an epigenome-wide association study
090 DNA methylation and its relationship with musculoskeletal health in older adults from the Hertfordshire Cohort Study: findings from an epigenome-wide association study Open
View article: Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress
Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress Open
Several studies suggest that low birthweight resulting from restricted intrauterine growth can leave a metabolic footprint which may persist into adulthood. To investigate this, we performed metabolomic profiling on 5036 female twins, aged…
View article: Within-Person Pain Variability and Mental Health in Older Adults With Osteoarthritis: An Analysis Across 6 European Cohorts
Within-Person Pain Variability and Mental Health in Older Adults With Osteoarthritis: An Analysis Across 6 European Cohorts Open
This study showed that more severe and stable joint pain levels were associated with anxiety and depressive symptoms in older persons with OA. These findings emphasize the importance of measuring pain in OA at multiple time points, because…
View article: Calcium and Vitamin D Supplementation Are Not Associated With Risk of Incident Ischemic Cardiac Events or Death: Findings From the UK Biobank Cohort
Calcium and Vitamin D Supplementation Are Not Associated With Risk of Incident Ischemic Cardiac Events or Death: Findings From the UK Biobank Cohort Open
We investigated associations between calcium/vitamin D supplementation and incident cardiovascular events/deaths in a UK population-based cohort. UK Biobank is a large prospective cohort comprising 502,637 men and women aged 40 to 69 years…
View article: Correlates of high-impact physical activity measured objectively in older British adults
Correlates of high-impact physical activity measured objectively in older British adults Open
Besides age and sex, several factors were associated with higher impact PA in later life. Our findings help identify characteristics of older people that might benefit from interventions designed to promote osteogenic PA.
View article: Concordance between clinical and radiographic evaluations of knee osteoarthritis
Concordance between clinical and radiographic evaluations of knee osteoarthritis Open
View article: Associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact physical activity in later life
Associations of lifetime walking and weight bearing exercise with accelerometer-measured high impact physical activity in later life Open