Explanipedia

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection 2954 Open

Alexandria J. Sturtz, Taylor A. Lyons, Lijo John, Akshaya Ramachandran, Allen M. Minns , et al. · 2025

Description Germinal center (GC)-derived plasma cells (PC) and memory B cells (MBC) are pivotal for the effective clearance of Plasmodium and protection against reinfections. However, suboptimal humoral immune response, emergence of drug-r…

Mechanisms of superior respiratory IgA responses against SARS-CoV-2 after mucosal vaccination 2158 Open

Arka Sen Chaudhuri, Pei Li, Yajie Liu, Yue Wu, Chaofan Li , et al. · 2025

Description Mucosal immunization and respiratory IgA responses offer significant promise in protecting against airborne pathogens, including SARS-CoV-2. However, However, the conditions and mechanisms that lead to the robust induction of r…

Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition Open

Rosie Lanzloth, Nicole C. Harris, Anthony Cannon, Mark H. Kaplan, Heather M. O’Hagan · 2025

Local Oxygen Tension Dictates Hematopoietic Cell Growth and Potency Open

James Ropa, Sarah Gutch, Lynne M. Wathen, Gracie Whitacre, Arafat Aljoufi , et al. · 2025

Hematopoietic stem and progenitor cells support a lifetime supply of blood and immune cells, can become neoplastic when dysregulated, and constitute a powerful cell therapy vehicle for hematologic diseases. Here we provide the most compreh…

24 | UNVEILING FOLLICULAR LYMPHOMA HETEROGENEITY: A SINGLE‐CELL ATLAS REVEALS PROGNOSTIC CELLULAR ECOSYSTEMS AND NOVEL BIOMARKERS ASSOCIATED WITH HIGH‐RISK Open

Alexandre Sarrabay, Sabrina Baaklini, Loïc Chartier, Catherine Barthélémy, L. Gil , et al. · 2025

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection Open

Carolina Calôba, Alexandria J. Sturtz, Taylor A. Lyons, Lijo John, Akshaya Ramachandran , et al. · 2025

T-dependent germinal center (GC) output, comprising plasma cells and memory B cells (MBCs), is crucial for clearance of Plasmodium infection and protection against reinfection. In this study, we examine the effect of an agonistic antibody …

CFTR negatively reprograms Th2 cell responses, and CFTR potentiation restrains allergic airway inflammation Open

Mark Rusznak, Christopher M. Thomas, Jian Zhang, Shinji Toki, Weisong Zhou , et al. · 2025

Type 2 inflammatory diseases, including asthma, sinusitis, and allergic bronchopulmonary aspergillosis, are common in cystic fibrosis (CF). CD4+ Th2 cells promote these diseases through secretion of IL-4, IL-5, and IL-13. Whether the CF tr…

Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition Open

Rosie Lanzloth, Nicole C. Harris, Anthony Cannon, Mark H. Kaplan, Heather M. O’Hagan · 2025

Mast cells (MCs), a type of granulocytic immune cell, can be both pro– and anti-tumorigenic in colorectal cancer (CRC). We hypothesized that these contrasting findings may be in part due to di_erential interactions of MCs with CRC subtypes…

A high-resolution view of the immune and stromal cell response to Haemophilus ducreyi infection in human volunteers Open

Julie A. Brothwell, Yuhui Wei, Jia Wang, Tingbo Guo, Chi Zhang , et al. · 2025

Haemophilus ducreyi causes the genital ulcer disease chancroid and cutaneous ulcers in children. To study its pathogenesis, we developed a human challenge model in which we infect the skin on the upper arm of human volunteers with H. ducre…

Give the grant-writing monkeys another banana Open

Mark H. Kaplan · 2025

IL-9 at the Maternal–Fetal Interface Defines an Immune Pathway for Idiopathic Preterm Labor and Birth Open

Roberto Romero, Roger Piqué-Regi, Sarah Niesen, SeungBaek Lee, Lucie Potůčková , et al. · 2025

The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect Open

Xiaoqun Guan, Hope Fury, Priya D. Issuree, Tyler Atagozli, Emory E. McManimon , et al. · 2024

Bone marrow transplantation (BMT) is mainly performed to restore an anti-tumor immune response, called the graft-versus-tumor (GVT) effect, against leukemia, myeloma and lymphoma. This GVT reactivity is driven by donor T cells, and it can …

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi Open

Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze , et al. · 2024

Borrelia (or Borreliella ) burgdorferi , the causative agent of Lyme disease, is a motile and invasive zoonotic pathogen adept at navigating between its arthropod vector and mammalian host. While motility and chemotaxis are well known to b…

Case Studies of Sustained Remission of Membranous Glomerulonephritis With Dupilumab Treatment Open

Mark H. Kaplan, Jessica Greco, Brad H. Rovin, Anthony Cannon, Abigail Pajulas , et al. · 2024

Abstract 33: Transcriptomic Identification of Functionally Potent Umbilical Cord Blood Units Open

James Ropa, Sarah Gutch, Lindsay Beasley, Wouter van’t Hof, Jessica Sun , et al. · 2024

Introduction Umbilical cord blood (UCB) is an important donor source for standard of care cellular therapies as well as innovative new treatments. Universal potency criteria for cord blood unit (CBU) selection for different cellular therap…

An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation Open

Nada S. Alakhras, Wenwu Zhang, Nicolas Barros, A. Sattainathan Sharma, James Ropa , et al. · 2024

Although many cytokine pathways are important for dendritic cell (DC) development, it is less clear what cytokine signals promote the function of mature dendritic cells. The signal transducer and activator of transcription 4 (STAT4) promot…

ImmunoHorizons Is the Cure Open

Mark H. Kaplan · 2024

HUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer Open

Nicole Ramos Solis, Anthony Cannon, Tinslee Dilday, Melissa Abt, Adrian L. Oblak , et al. · 2024

Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). TNBC tumors are not sensitive to endocrine therapy, and standardized TNBC…

Protocol for enrichment and functional analysis of human hematopoietic cells from umbilical cord blood Open

Sarah Gutch, Lindsay Beasley, Scott Cooper, Mark H. Kaplan, Maegan L. Capitano , et al. · 2024

Umbilical cord blood (CB) is a donor source for hematopoietic cell therapies. Understanding what drives hematopoietic stem and progenitor cell function is critical to our understanding of the usage of CB in hematopoietic cell therapies. He…

TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma Open

Michelle Niese, Abigail Pajulas, Cameron R. Rostron, Cherry Cheuk Lam Cheung, Maya S. Krishnan , et al. · 2024

Allergen-specific IgE inhibitors block anaphylactic responses by targeting allergen recognition Open

Başar Bilgiçer, Mark H. Kaplan · 2024

Assessment of IL-9/IL-9R Expression and Therapeutic Effect of IL-9 Blockade in a Mouse Breast Cancer Model Open

Amir Hailat, Jilu Zhang, Mark H. Kaplan · 2024

Background and Hypothesis:IL-9 is a cytokine produced by TH9, mast cells, and innate lymphoid cells. IL-9 acts on the IL-9 receptor (IL-9R) and is primarily involved in parasitic immunity and allergic inflammation. IL-9 has anti-tumor effe…

Fibronectin Promotes Wound Healing in an Atopic Human Skin Xenografting Model Open

Wenwu Zhang, Nahid Akhtar, Jennifer Zhao, Dan F. Spandau, Mark H. Kaplan · 2023

Biofilm-derived oxylipin 10-HOME–mediated immune response in women with breast implants Open

Imran Khan, Robert E. Minto, Christine Kelley-Patteson, Kanhaiya Singh, Lava Timsina , et al. · 2023

This study investigates a mechanistic link of bacterial biofilm-mediated host-pathogen interaction leading to immunological complications associated with breast implant illness (BII). Over 10 million women worldwide have breast implants. I…

STAT3 Signaling Heterogeneity Underlies Cytokine-Expressing Fate in Th17 Cultures Open

Michelle Niese, Nicole L. Glosson-Byers, Ana Paula Moreira Serezani, Nada S. Alakhras, Mark H. Kaplan · 2023

The polarization of naive Th cells into differentiated subsets in vitro was a powerful approach to define the development and function of Th cells in vivo. Th cell cultures identified cytokines that promote polarization and defined the phe…

Insights into highly engraftable hematopoietic cells from 27-year cryopreserved umbilical cord blood Open

Hal E. Broxmeyer, Larry L. Luchsinger, Rona Singer Weinberg, Alexandra Jimenez, Emeline Masson Frenet , et al. · 2023

Umbilical cord blood transplantation is a life-saving treatment for malignant and non-malignant hematologic disorders. It remains unclear how long cryopreserved units remain functional, and the length of cryopreservation is often used as a…

Submit to ImmunoHorizons or I Will Write Another Editorial Open

Mark H. Kaplan · 2023

The World according to IL-9 Open

Abigail Pajulas, Jilu Zhang, Mark H. Kaplan · 2023

Among the cytokines regulating immune cells, IL-9 has gained considerable attention for its ability to act on multiple cell types as a regulator of beneficial and pathologic immune responses. Yet, it is still not clearly defined how IL-9 i…

Loricrin and Cytokeratin Disorganisation in Severe Forms of Periodontitis Open

Raisa Queiroz Catunda, Karen Ka-yan Ho, Srushti Patel, Christopher Bryant Roy, Maria Alexiou , et al. · 2023

Our study provides evidence that changes in epithelial organisation can exacerbate the effects of P gingivalis infection, with similarities to the most severe forms of human periodontitis.

The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment Open

Anthony Cannon, Abigail Pajulas, Mark H. Kaplan, Jilu Zhang · 2023

Interleukin 9 (IL-9) is a cytokine with potent proinflammatory properties that plays a central role in pathologies such as allergic asthma, immunity to parasitic infection, and autoimmunity. More recently, IL-9 has garnered considerable at…

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