Gary M. Halliday
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View article: Data from Snail Up-regulates Proinflammatory Mediators and Inhibits Differentiation in Oral Keratinocytes
Data from Snail Up-regulates Proinflammatory Mediators and Inhibits Differentiation in Oral Keratinocytes Open
The transcriptional repressor Snail2 is overexpressed in head and neck squamous cell carcinomas (HNSCC) relative to nonmalignant head and neck mucosal epithelium, and in locally recurrent relative to nonrecurrent HNSCCs. We investigated th…
View article: Data from Snail Up-regulates Proinflammatory Mediators and Inhibits Differentiation in Oral Keratinocytes
Data from Snail Up-regulates Proinflammatory Mediators and Inhibits Differentiation in Oral Keratinocytes Open
The transcriptional repressor Snail2 is overexpressed in head and neck squamous cell carcinomas (HNSCC) relative to nonmalignant head and neck mucosal epithelium, and in locally recurrent relative to nonrecurrent HNSCCs. We investigated th…
Sex Differences in Photoprotective Responses to 1,25-Dihydroxyvitamin D3 in Mice Are Modulated by the Estrogen Receptor-β Open
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than in female humans and mice and is exacerbated in female estrogen receptor-beta knockout (ER-β−/−) mice. We previously reported that the active vitamin…
Sex Differences in Photoprotective Responses to 1,25- Dihydroxyvitamin D3 in Mice are Modulated by the Estrogen Receptor-β Open
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than in female humans and mice and is exacerbated in female estrogen receptor-beta knockout (ER-β-/-) mice. We previously reported that the active vitamin…
Neurocognitive Function and Quality of Life Outcomes in the ONTRAC Study for Skin Cancer Chemoprevention by Nicotinamide Open
Nicotinamide (vitamin B3) has photoprotective effects and reduces skin cancer incidence in high risk patients. Nicotinamide also improves cognition in animal models. As part of the ONTRAC (Oral Nicotinamide To Reduce Actinic Cancer) phase …
Melanoma and nonmelanoma skin cancer chemoprevention: A role for nicotinamide? Open
Summary Ultraviolet radiation ( UVR ) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8‐oxo‐7‐hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammat…
Damaging Effects of Ultraviolet Radiation on the Cornea Open
The cornea sits at the anterior aspect of the eye and, like the skin, is highly exposed to ultraviolet radiation ( UVR ). The cornea blocks a significant proportion of UVB from reaching the posterior structures of the eye. However, UVA can…
Self-organized centripetal movement of corneal epithelium in the absence of external cues Open
Maintaining the structure of the cornea is essential for high-quality vision. In adult mammals, corneal epithelial cells emanate from stem cells in the limbus, driven by an unknown mechanism towards the centre of the cornea as cohesive clo…