Thomas Folkmann Hansen
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View article: Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis
Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis Open
Importance Smoking and obesity are associated with risk of hidradenitis suppurativa, and both are considered important environmental risk factors. However, a causal relationship remains unproven. Objective To primarily investigate the rela…
Endothelial Cell Loss 1 Year After Successful DMEK in the Diabetes Endothelial Keratoplasty Study Open
Importance The effect of cornea donor diabetes on endothelial cell density (ECD) and morphometry after Descemet membrane endothelial keratoplasty (DMEK) is not known. Objective To determine whether endothelial cell loss (ECL) and morphomet…
A structural deletion in the 3′ <span>UTR</span> of <i>SLC11A2</i> is associated with altered iron status: Evidence from two large Danish cohorts Open
Summary The SLC11A2 gene encodes divalent metal transporter 1, a key mediator of cellular and intestinal iron transport. While ultra‐rare pathogenic variants in SLC11A2 cause autosomal recessive anaemia with iron overload, the phenotypic c…
View article: The genetic architecture of fibromyalgia across 2.5 million individuals
The genetic architecture of fibromyalgia across 2.5 million individuals Open
Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls)…
Protein tyrosine phosphatase receptor type D - A convergent risk gene for MDD, BPD, and ADHD and regulator of dopaminergic neuroplasticity in reward associated circuits; A multivariate GWAS, brain tissue and cell type enrichment, and gene fine-mapping Open
Major depressive disorder (MDD), bipolar disorder (BPD), and attention-deficit hyperactivity disorder (ADHD), are prevalent, highly heritable psychiatric disorders with significant degrees of genetic overlap. Using open-sourced summary sta…
View article: Genome sequencing reveals the <i>Adgrl3</i> ( <i>ADGRL3</i> ) gene as a possible cause of cephalic hypersensitivity in the STA rat and migraine in humans
Genome sequencing reveals the <i>Adgrl3</i> ( <i>ADGRL3</i> ) gene as a possible cause of cephalic hypersensitivity in the STA rat and migraine in humans Open
Background Migraine is a common primary headache disorder with a significant genetic component influencing its pathophysiology, in which the trigeminal system plays a central role. The spontaneous trigeminal allodynia (STA) inbred rat stra…
View article: Diagnosing migraine from genome-wide genotype data: a machine learning analysis
Diagnosing migraine from genome-wide genotype data: a machine learning analysis Open
Migraine has an assumed polygenic basis, but the genetic risk variants identified in genome-wide association studies only explain a proportion of the heritability. We aimed to develop machine learning models, capturing non-additive and int…
View article: Translational genomics of osteoarthritis in 1,962,069 individuals
Translational genomics of osteoarthritis in 1,962,069 individuals Open
Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes 1 . By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide 2 . As no dis…
View article: Population-scale inheritance analysis of 858,635 individuals reveals North Sea migration from the Middle Ages to the Industrial Revolution
Population-scale inheritance analysis of 858,635 individuals reveals North Sea migration from the Middle Ages to the Industrial Revolution Open
The North Sea’s historical migrations have impacted the genetic structure of its neighbouring populations. We analysed haplotype sharing among 858,635 modern individuals from Denmark and Britain to infer migration history from the Middle A…
Lost earnings among triptan non-responders in the general population of Denmark: a measure of disproportionate migraine-attributed burden and of unrecognised and unmet treatment need Open
Triptan non-response represents failure of currently available acute treatment options. It is associated with substantial and cumulative lost earnings, highlighting a disproportionate economic burden. These findings underscore the potentia…
Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study Open
Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured …
View article: Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy
Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy Open
As populations get older and medicine consumption rises, the rate of concurrent drug use and polypharmacy among patients is increasing. Polypharmacy is known to complicate therapy and increase the risk of drug-drug interactions, the indivi…
View article: Acceptance and attitudes towards COVID-19 vaccination during pregnancy in Canada
Acceptance and attitudes towards COVID-19 vaccination during pregnancy in Canada Open
The COVID-19 pandemic posed a unique set of risks to pregnant women and pregnant people. SARS-CoV-2 infection in pregnancy is associated with increased risk of severe illness and adverse perinatal outcomes. However, evidence regarding the …
Impaired health-related quality of life, and depressive symptoms in a cohort of healthy adults with symptoms of attention deficit/hyperactivity disorder Open
Background Attention deficit/hyperactivity disorder (ADHD) prevalence has increased in the last 10 years, most likely due to increased recognition by clinicians. Even so, an issue with under-diagnostics may persist. Historically ADHD has b…
View article: Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders
Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders Open
We conducted the largest genome-wide meta-analysis of borderline personality disorder (BPD) to date, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 cases and 107,750 controls (all participant…
Corroborating written history with ancient DNA: The case of the Well-man described in an Old Norse saga Open
The potential of ancient DNA analyses to provide independent sources of information about events in the historical record remains to be demonstrated. Here we apply palaeogenomic analysis to human remains excavated from a medieval well at t…
No association between migraine and HLA alleles in a cohort of 13,210 individuals with migraine from the Danish Blood Donor Study Open
Objective To determine the association between human leukocyte antigen (HLA) alleles and migraine, migraine subtypes, and sex‐specific factors. Background It has long been hypothesized that inflammation contributes to migraine pathophysiol…
View article: Developmental language disorder – heritability and genetic correlations with other disorders affecting language
Developmental language disorder – heritability and genetic correlations with other disorders affecting language Open
Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies in…
Cost of illness and labour market disaffiliation among patients with migraine discontinuing triptan treatment: A Danish nationwide register study from 1995 to 2021 Open
Background Migraine presents significant health and economic challenges. Despite the widespread use of triptans, some patients discontinue them because of insufficient relief or adverse effects. Using national registers, the present study …