Mark Harber
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View article: Kidney Transplant Outcomes With Non-Depleting Antibody Induction Therapy in Human Leucocyte Antigen Sensitised Recipients
Kidney Transplant Outcomes With Non-Depleting Antibody Induction Therapy in Human Leucocyte Antigen Sensitised Recipients Open
Lymphocyte depleting induction is recommended for kidney transplant recipients (KTRs) at high immunological risk, which traditionally includes those with detectable anti-human leucocyte antigen antibodies. Data to support this approach in …
View article: The climate crisis is a global health emergency: A call to arms
The climate crisis is a global health emergency: A call to arms Open
View article: Older Kidney Transplant Patients Are Over Immunosuppressed Using Standard Protocols With Differential Sex‐Based Complications
Older Kidney Transplant Patients Are Over Immunosuppressed Using Standard Protocols With Differential Sex‐Based Complications Open
Background Increasing numbers of older patients are undergoing kidney transplantation. While there is evidence for both sex‐ and age‐related immunological variations increasing the risks of immunosuppression (IS), few centers enforce age‐ …
View article: Composition of the neutralising antibody response predicts risk of BK virus DNAaemia in recipients of kidney transplants
Composition of the neutralising antibody response predicts risk of BK virus DNAaemia in recipients of kidney transplants Open
View article: Corrigendum to “Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV” [Kidney International Reports Volume 7, Issue 4, April 2022, Pages 786-796]
Corrigendum to “Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV” [Kidney International Reports Volume 7, Issue 4, April 2022, Pages 786-796] Open
[This corrects the article DOI: 10.1016/j.ekir.2022.01.1054.].
View article: #1569 Cytomegalovirus (CMV) infection in renal transplant patients managed with early pre-emptive treatment
#1569 Cytomegalovirus (CMV) infection in renal transplant patients managed with early pre-emptive treatment Open
Background and Aims Human Cytomegalovirus (CMV) can cause significant morbidity in transplant recipients. Primary CMV infection in CMV seronegative recipients (R−) and reactivation of CMV in seropositive recipients (R+) post-transplant can…
View article: Optimising Diabetes Care for Kidney Transplant Recipients
Optimising Diabetes Care for Kidney Transplant Recipients Open
Diabetes is the leading cause of end-stage kidney disease (ESKD) worldwide.
View article: Persistent Low-Level Variants in a Subset of Viral Genes Are Highly Predictive of Poor Outcome in Immunocompromised Patients With Cytomegalovirus Infection
Persistent Low-Level Variants in a Subset of Viral Genes Are Highly Predictive of Poor Outcome in Immunocompromised Patients With Cytomegalovirus Infection Open
Background Human cytomegalovirus (HCMV) is the most common and serious opportunistic infection after solid organ and hematopoietic stem cell transplantation. In this study, we used whole-genome HCMV data to investigate viral factors associ…
View article: The (Un)Sustainability of Nephrology
The (Un)Sustainability of Nephrology Open
The rising prevalence of patients living with kidney disease and the recognition of the huge environmental impact of kidney care (mainly dialysis treatments) points to the unsustainability of nephrology in the near future, which has forced…
View article: Table of Contents
Table of Contents Open
View article: Binding Truths: Seronegative Anti-Glomerular Basement Membrane Disease Mediated by IgM Anti-Glomerular Basement Membrane Antibodies
Binding Truths: Seronegative Anti-Glomerular Basement Membrane Disease Mediated by IgM Anti-Glomerular Basement Membrane Antibodies Open
View article: Our shared responsibility: the urgent necessity of global environmentally sustainable kidney care
Our shared responsibility: the urgent necessity of global environmentally sustainable kidney care Open
In response to Earth's accelerating climate crisis, we, an international group of nephrologists, call on our global community to unite and align kidney care in accordance with United Nation's 26th Conference of the Parties health sector pr…
View article: Application of Various Techniques to Gain Insights Into the Complex Urinary Tract Microbial Communities of Renal Transplant Recipients
Application of Various Techniques to Gain Insights Into the Complex Urinary Tract Microbial Communities of Renal Transplant Recipients Open
Background. Urinary tract infections (UTIs) are prevalent in renal transplant (RT X ) recipients and associated with worse outcomes. Early detection by sensitive diagnostic tests and appropriate treatment strategies in this cohort is there…
View article: Persistent low-level variants in a subset of HCMV genes are highly predictive of poor outcome in immunocompromised patients with cytomegalovirus infection
Persistent low-level variants in a subset of HCMV genes are highly predictive of poor outcome in immunocompromised patients with cytomegalovirus infection Open
Human cytomegalovirus (HCMV) is the most common and most serious opportunistic infection after solid organ (SOT) and haematopoietic stem cell transplantation (HSCT). There is considerable interest in using virus sequence data to investigat…
View article: Donor–recipient human leukocyte antigen A mismatching is associated with hepatic artery thrombosis, sepsis, graft loss, and reduced survival after liver transplant
Donor–recipient human leukocyte antigen A mismatching is associated with hepatic artery thrombosis, sepsis, graft loss, and reduced survival after liver transplant Open
Human leukocyte antigen (HLA) matching is not routinely performed for liver transplantation as there is no consistent evidence of benefit; however, the impact of HLA mismatching remains uncertain. We explored the effect of class I and II H…
View article: Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV
Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV Open
APOL1 high-risk genotypes were strongly associated with kidney disease in people of African ancestry with HIV and accounted for approximately half of ESKD cases in this cohort.
View article: Urinary Tract Infection
Urinary Tract Infection Open
View article: Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV
Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV Open
View article: The epidemiology of kidney disease in people of African ancestry with HIV in the UK
The epidemiology of kidney disease in people of African ancestry with HIV in the UK Open
Our results indicate that people of West African ancestry with HIV are at increased risk of kidney disease. Although we cannot rule out the possibility of residual confounding, geographical region of origin appears to be a strong independe…
View article: Delayed diagnoses of mitochondrial cytopathies in patients presenting with end stage kidney disease: two case reports
Delayed diagnoses of mitochondrial cytopathies in patients presenting with end stage kidney disease: two case reports Open
Background Up to one third of patients on renal replacement programmes have an unknown cause of kidney disease, and the diagnosis may only be established following renal transplantation when the disease recurs or if new extra-renal symptom…
View article: Outcomes following kidney transplantation in patients with sickle cell disease: The impact of automated exchange blood transfusion
Outcomes following kidney transplantation in patients with sickle cell disease: The impact of automated exchange blood transfusion Open
There are over 12,000 people with sickle cell disease (SCD) in the UK, and 4-12% of patients who develop Sickle Cell Nephropathy (SCN) progress to End Stage Renal Disease (ESRD). Renal transplantation offers the best outcomes for these pat…
View article: Positive complement-dependent cytotoxicity crossmatch results do not influence long-term graft or patient survival following liver transplantation
Positive complement-dependent cytotoxicity crossmatch results do not influence long-term graft or patient survival following liver transplantation Open
View article: SUN-053 OUTCOMES FOLLOWING KIDNEY TRANSPLANTATION IN PATIENTS WITH SICKLE CELL DISEASE WITH AND WITHOUT EXCHANGE BLOOD TRANSFUSION
SUN-053 OUTCOMES FOLLOWING KIDNEY TRANSPLANTATION IN PATIENTS WITH SICKLE CELL DISEASE WITH AND WITHOUT EXCHANGE BLOOD TRANSFUSION Open
Renal transplantation offers the best outcome for sickle cell disease (SCD) patients with End Stage Renal Disease, although outcomes are poorer than in other groups. Regular exchange blood transfusions (EBT) reduce the complications of SCD…
View article: Tuberculosis following renal transplantation in England, Wales and Northern Ireland: a national registry-based cohort study
Tuberculosis following renal transplantation in England, Wales and Northern Ireland: a national registry-based cohort study Open
Among a nationwide cohort of renal transplant recipients (n=30 433), TB incidence was highest in the first year post-transplant. Asian ethnicity and CMV seropositivity were independent risk factors for post-transplant TBhttp://bit.l…
View article: Cytomegalovirus viral load parameters associated with earlier initiation of pre-emptive therapy after solid organ transplantation
Cytomegalovirus viral load parameters associated with earlier initiation of pre-emptive therapy after solid organ transplantation Open
Pre-emptive therapy initiated at the first sign of viraemia post-transplant significantly reduced the peak viral load but increased later episodes of viraemia, consistent with the hypothesis of reduced antigenic stimulation of the immune s…
View article: A histopathological comparison of pulpal response to formocresol and sodium hypochlorite used as pulpotomy medicaments: In primary teeth – A clinical trialA histopathological comparison of pulpal response to formocresol and sodium hypochlorite used as pulpotomy medicaments: In primary teeth – A clinical trial
A histopathological comparison of pulpal response to formocresol and sodium hypochlorite used as pulpotomy medicaments: In primary teeth – A clinical trialA histopathological comparison of pulpal response to formocresol and sodium hypochlorite used as pulpotomy medicaments: In primary teeth – A clinical trial Open
Cytomegalovirus (CMV) is one of opportunistic infections post solid organ transplant and remains a cause of morbidity and mortality. Mammalian target of rapamycin inhibitors has a theoretical antiviral advantage compared to conventional im…
View article: Binding Truths: Atypical Anti−Glomerular Basement Membrane Disease Mediated by IgA Anti−Glomerular Basement Membrane Antibodies Targeting the α1 Chain of Type IV Collagen
Binding Truths: Atypical Anti−Glomerular Basement Membrane Disease Mediated by IgA Anti−Glomerular Basement Membrane Antibodies Targeting the α1 Chain of Type IV Collagen Open
Anti−glomerular basement membrane (anti-GBM) disease presents with rapidly progressive glomerulonephritis, often associated with alveolar hemorrhage and characterized histologically by crescentic glomerulonephritis. Typically, there is lin…
View article: SP710URINARY TRACT INFECTIONS AFTER KIDNEY TRANSPLANTATION: A RETROSPECTIVE SINGLE CENTRE STUDY
SP710URINARY TRACT INFECTIONS AFTER KIDNEY TRANSPLANTATION: A RETROSPECTIVE SINGLE CENTRE STUDY Open
View article: Correction: Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy
Correction: Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy Open
[This corrects the article DOI: 10.1371/journal.pone.0163722.].
View article: Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy
Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy Open
The results illustrate that patients have continuing risks for CMV infection with limited time available for intervention. We see no need to alter current rules for stopping or starting pre-emptive therapy.